DRSC/TRiP Functional Genomics Resources

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Protein Alignment JAG1 and arg-1

DIOPT Version :10

Sequence 1:NP_000205.1 Gene:JAG1 / 182 HGNCID:6188 Length:1218 Species:Homo sapiens
Sequence 2:NP_001024615.1 Gene:arg-1 / 180501 WormBaseID:WBGene00000185 Length:357 Species:Caenorhabditis elegans


Alignment Length:395 Identity:88/395 - (22%)
Similarity:122/395 - (30%) Gaps:144/395 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    21 LCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSR 85
            ||::..  ..|||..||.|.|.|:|   |.....|...:.|     ..||......|        
 Worm    12 LCSIAD--TNASGIIELLISSPQSV---LIKSTACASFKCP-----VHDELSVPRNV-------- 58

Human    86 VTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLL-VEAWDSSNDTVQPD 149
                      .|..|:    ..::...||..|..|.|.|....|.:..:| :|...:.:||    
 Worm    59 ----------EGGVPL----RIHIGQYRGEARQNIDLHFEILEPSTNEMLALEQHRAPSDT---- 105

Human   150 SIIEKASHSGMINPSRQWQTLKQNTGVA---------HFEYQIRVTCDDYYYGFGCNKFCRPRDD 205
                                 |.|||:.         :....:|..|...|||..||::|.|...
 Worm   106 ---------------------KWNTGLPIVIETTLGFNVTVHLRNVCTSNYYGKRCNRYCIPSPA 149

Human   206 FFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPG 270
            .  |:.|..||.:.|..||.|.:|:                                        
 Worm   150 L--HWECSTNGVRQCAVGWYGDDCS---------------------------------------- 172

Human   271 CVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEI 335
                                    .::.:|....||.|||.||.    .|:|.||..:.||.||.
 Worm   173 ------------------------SNIKFCSHQNPCANGGVCST----DYKCQCPSEFLGPRCET 209

Human   336 ---AEHACLSDPCHNRGSCKETS-LGFECECSPGWTGPTCSTNI-DDCSPNNCSHGGTCQDLVNG 395
               ..|..|...|.:.|:|...: ...:|:|..|:.|..|...| .:||...||...|||  :..
 Worm   210 PVSKVHCTLERVCKHGGTCVSVNRTNVQCKCIRGFLGSLCEIGIHGNCSAMRCSVDETCQ--IRA 272

Human   396 FKCVC 400
            ...||
 Worm   273 SFAVC 277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JAG1NP_000205.1 MNNL 32..185 CDD:462222 31/162 (19%)
DSL 167..229 CDD:128366 21/70 (30%)
Important for interaction with NOTCH1. /evidence=ECO:0000269|PubMed:18660822 199..207 2/7 (29%)
EGF_CA 296..334 CDD:238011 14/37 (38%)
EGF 340..370 CDD:394967 8/30 (27%)
EGF_CA 374..410 CDD:238011 10/28 (36%)
EGF_CA 412..447 CDD:238011
EGF_CA 450..485 CDD:238011
EGF_CA 487..523 CDD:238011
EGF_CA 525..560 CDD:238011
EGF_CA 629..665 CDD:238011
EGF_CA 667..702 CDD:238011
EGF 748..777 CDD:394967
EGF_CA 782..817 CDD:238011
EGF_CA 820..856 CDD:238011
VWC_out 863..930 CDD:214565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1152..1218
arg-1NP_001024615.1 DSL 107..171 CDD:128366 20/65 (31%)
EGF_CA 174..208 CDD:238011 14/37 (38%)
Blue background indicates that the domain is not in the aligned region.

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