| Sequence 1: | NP_000205.1 | Gene: | JAG1 / 182 | HGNCID: | 6188 | Length: | 1218 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_499007.1 | Gene: | lin-12 / 176282 | WormBaseID: | WBGene00003001 | Length: | 1429 | Species: | Caenorhabditis elegans |
| Alignment Length: | 1195 | Identity: | 293/1195 - (24%) |
|---|---|---|---|
| Similarity: | 441/1195 - (36%) | Gaps: | 370/1195 - (30%) |
- Green bases have known domain annotations that are detailed below.
|
Human 243 GSCKLPGDCRCQYGWQGLYCDK---CIPHPGCVHGICNEPWQCLCETNWGGQLCDK--DLNYCGT 302
Human 303 HQPCLNG----------GTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLG 357
Human 358 FECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECE--AKP 420
Human 421 CVNAKSCKNLIASYYCDCLPGWMGQNC------------------DININDCLGQ---CQNDASC 464
Human 465 RDLVNGYRCICPPGYAGDHCE--RDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDID 527
Human 528 YCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVR 592
Human 593 YISSNVCGPHGKC--KSQSGGKFTCDCNKGFTGTYCHENINDCES-NPCRNGGTCIDGVNSYKCI 654
Human 655 CSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDF--YCDCKNGWKGKTCHSR----------DS 707
Human 708 QCDEATCN-NGGTCYDEGDAFK--CMCPGGWEGTTCNIARNSS--------CLPNPCHNGGTCV- 760
Human 761 VNGE-SFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDC-RININE 823
Human 824 CQSSPCAFGATCV-DEINGYRCVCPPGHSGAKCQE---VSG--------------RPCITMGSVI 870
Human 871 PDGAKWDDDCNTCQC---------------------------LNGRIACSKVWCGPRPCLLHKGH 908
Human 909 SECPSGQSCIP--------------------ILDDQCFVHPCTGV--GECRSSS----------- 940
Human 941 --LQPVKTKCTSDS--------------YYQDNCANITFTFNKE-------MMSPGLTTEHICSE 982
Human 983 LRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKR---DG 1044
Human 1045 NSSLIAAVAEVRV-QRRPLKNRTDFLVPLLSSVLTVAWICCLVTAFYWC-------LRKRRKPG- 1100
Human 1101 ---------------------SHTHSASEDNTTNNVREQLNQI---------------------- 1122
Human 1123 -------------KNPIEKHG------ANTVPIK-------DYENKNSKMSKIRTHNSEVEEDDM 1161
Human 1162 DKHQQKARFAKQPAYTLVDREEKPP 1186 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| JAG1 | NP_000205.1 | MNNL | 32..106 | CDD:284966 | |
| DSL | 167..229 | CDD:279722 | |||
| Important for interaction with NOTCH1. /evidence=ECO:0000269|PubMed:18660822 | 199..207 | ||||
| EGF_CA | 296..334 | CDD:238011 | 12/47 (26%) | ||
| EGF | 340..370 | CDD:278437 | 2/29 (7%) | ||
| EGF_CA | 374..410 | CDD:238011 | 12/35 (34%) | ||
| EGF_CA | 412..447 | CDD:238011 | 13/36 (36%) | ||
| EGF_CA | 450..485 | CDD:238011 | 13/37 (35%) | ||
| EGF_CA | 487..523 | CDD:238011 | 16/35 (46%) | ||
| EGF_CA | 525..560 | CDD:238011 | 13/34 (38%) | ||
| EGF_CA | 629..665 | CDD:238011 | 14/36 (39%) | ||
| EGF_CA | 667..702 | CDD:238011 | 15/36 (42%) | ||
| EGF | 748..777 | CDD:278437 | 13/30 (43%) | ||
| EGF_CA | 782..817 | CDD:238011 | 12/34 (35%) | ||
| EGF_CA | 820..856 | CDD:238011 | 13/36 (36%) | ||
| VWC_out | 863..930 | CDD:214565 | 20/113 (18%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1152..1218 | 8/35 (23%) | |||
| lin-12 | NP_499007.1 | EGF_CA | 152..189 | CDD:238011 | 13/36 (36%) |
| EGF_CA | 252..285 | CDD:238011 | 16/33 (48%) | ||
| EGF_CA | 293..323 | CDD:238011 | 11/29 (38%) | ||
| EGF_CA | 365..401 | CDD:238011 | 14/35 (40%) | ||
| EGF_CA | 505..541 | CDD:238011 | 15/35 (43%) | ||
| EGF_CA | 545..579 | CDD:238011 | 12/33 (36%) | ||
| NL | 635..668 | CDD:197463 | 9/36 (25%) | ||
| Notch | 675..709 | CDD:278494 | 7/44 (16%) | ||
| Notch | 722..750 | CDD:278494 | 6/28 (21%) | ||
| NOD | 754..804 | CDD:284282 | 3/49 (6%) | ||
| NODP | 842..898 | CDD:284987 | 11/55 (20%) | ||
| ANK | 1046..1186 | CDD:238125 | 10/52 (19%) | ||
| ANK repeat | 1052..1091 | CDD:293786 | 6/38 (16%) | ||
| Ank_4 | 1053..1113 | CDD:290365 | 9/45 (20%) | ||
| ANK repeat | 1093..1124 | CDD:293786 | 2/5 (40%) | ||
| Ank_4 | 1094..1147 | CDD:290365 | 2/4 (50%) | ||
| ANK repeat | 1126..1160 | CDD:293786 | |||
| ANK | 1160..1292 | CDD:238125 | |||
| ANK repeat | 1162..1201 | CDD:293786 | |||
| Ank_2 | 1167..1271 | CDD:289560 | |||
| ANK repeat | 1203..1238 | CDD:293786 | |||
| ANK repeat | 1240..1271 | CDD:293786 | |||
| Pap_E4 | 1306..>1373 | CDD:280813 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E33208_3BAFT | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 1 | 1.000 | - | - | mtm9800 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.810 | |||||