DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment JAG1 and jag1b

DIOPT Version :10

Sequence 1:NP_000205.1 Gene:JAG1 / 182 HGNCID:6188 Length:1218 Species:Homo sapiens
Sequence 2:NP_571938.2 Gene:jag1b / 140423 ZFINID:ZDB-GENE-011128-4 Length:1213 Species:Danio rerio


Alignment Length:1207 Identity:902/1207 - (74%)
Similarity:1026/1207 - (85%) Gaps:12/1207 - (0%)


- Green bases have known domain annotations that are detailed below.


Human    17 LLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKE 81
            |.|.|..||..|..|||.||||||||||.|||||||.||.|||||.|||||||||||||||||||
Zfish    14 LHAFLLCLRTTVSDASGHFELEILSMQNANGELQNGACCDGARNPADRKCTRDECDTYFKVCLKE 78

Human    82 YQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTV 146
            |||||::.|.||||:|||||:|||.|:.|.:| ::::||||||||||||||||:|||.|.:|:|.
Zfish    79 YQSRVSSAGACSFGTGSTPVLGGNKFSTKGTR-SEKSRIVLPFSFAWPRSYTLIVEALDFNNETA 142

Human   147 -QPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHY 210
             :...:||||.|||||||:||||.|..|..||.|||||||||.::||||||||||||||:|||||
Zfish   143 SESGKLIEKAYHSGMINPNRQWQRLTHNGPVAQFEYQIRVTCLEHYYGFGCNKFCRPRDEFFGHY 207

Human   211 ACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGI 275
            .|||||||||:|||.||:||.||||||||.:|||||.||.|:|.|||||.||||||||||||||.
Zfish   208 TCDQNGNKTCLEGWTGPDCNTAICRQGCSTEHGSCKQPGGCKCLYGWQGPYCDKCIPHPGCVHGT 272

Human   276 CNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHAC 340
            |.|||||||:|||||||||||||||||||||||||||||||||||||||.:||||.|||.|||||
Zfish   273 CVEPWQCLCDTNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCEDGYSGVNCERAEHAC 337

Human   341 LSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWT 405
            ||:||.|.|:|||||.|:||.|:.||:|.:|..|:|||:||.|.||||||||||||||.|||.||
Zfish   338 LSNPCANGGTCKETSQGYECHCAIGWSGTSCEINVDDCTPNQCKHGGTCQDLVNGFKCACPPHWT 402

Human   406 GKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNG 470
            |||||:||||||.|||||||||.|||.:|:|:|||||.|||||||||||.|||.|..:|:|||||
Zfish   403 GKTCQIDANECEDKPCVNAKSCHNLIGAYFCECLPGWSGQNCDININDCKGQCLNGGTCKDLVNG 467

Human   471 YRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQ 535
            |||:|||||.|:.||:|:|||||:||||||.||:|:|.||||||.||||.|||||||||:|||||
Zfish   468 YRCLCPPGYTGEQCEKDVDECASSPCLNGGRCQDEVNGFQCLCPAGFSGQLCQLDIDYCKPNPCQ 532

Human   536 NGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCG 600
            |||||:|.|||||||||:|||||||||||||||||.|:||||||||:|||.||||||||||||||
Zfish   533 NGAQCFNLASDYFCKCPDDYEGKNCSHLKDHCRTTSCQVIDSCTVAVASNSTPEGVRYISSNVCG 597

Human   601 PHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCE 665
            |||:|:||:||:|||:|.:||.||||||||||||||||||||||||.||.|:|||:|||||.:||
Zfish   598 PHGRCRSQAGGQFTCECQEGFRGTYCHENINDCESNPCRNGGTCIDKVNVYQCICADGWEGVHCE 662

Human   666 TNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCM 730
            .||:|||.|||.|.|.|:||||||||:|:||||||||||||||||||||||||||:||||.|||.
Zfish   663 INIDDCSLNPCLNKGACQDLVNDFYCECRNGWKGKTCHSRDSQCDEATCNNGGTCHDEGDTFKCR 727

Human   731 CPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSG 795
            |..||||.|||||:|||||||||.|||||||||:||.|||||||||..|.:|||||:||||||||
Zfish   728 CSPGWEGATCNIAKNSSCLPNPCENGGTCVVNGDSFNCVCKEGWEGSTCTENTNDCNPHPCYNSG 792

Human   796 TCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSG 860
            |||||:|||||||||||||||||||||||||||||||:|||||||||||:||||..|..||||.|
Zfish   793 TCVDGENWYRCECAPGFAGPDCRININECQSSPCAFGSTCVDEINGYRCLCPPGRIGPDCQEVVG 857

Human   861 RPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQC 925
            ||||..|.|..|||||::|||.|||.||||.|:.:||||:.|...|....||:.|||:||.::||
Zfish   858 RPCIANGQVTADGAKWEEDCNICQCQNGRIHCTMMWCGPKSCRTGKARGGCPASQSCVPIKEEQC 922

Human   926 FVHPCTGVGECRSSSLQPVKTKC-TSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNIL 989
            ||.||..:|||..|: .|..:|| .|.||..|:|||||||||||.|..||:.||:|:|||:..:|
Zfish   923 FVKPCPSLGECWPSA-PPPPSKCHASFSYQDDSCANITFTFNKENMPQGLSVEHVCNELRHWYLL 986

Human   990 KNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAE 1054
            ||:|.||::.|:||||.||:||||::||.|:.|.|.:|||:||.:|||||||.:|||::|.|:..
Zfish   987 KNLSTEYAVSISCEPSSSASNEIHISISTEEPRTDRSPIKDITVQIIDLVSKHNGNSTIIKAITG 1051

Human  1055 VRVQRRPLKNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTH---SASEDNTTNNVR 1116
            |||.:.| ..:||:|||||||:..|.||..|.:||.||:.:|||..:|::   ||:|||||||||
Zfish  1052 VRVHQIP-SPKTDYLVPLLSSIFIVLWIFALASAFLWCIHRRRKQNTHSNTATSATEDNTTNNVR 1115

Human  1117 EQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDR 1181
            |||||||||||||.|:.|||||||.|||.::|||||||||||:|||||.|||||.||||||||:|
Zfish  1116 EQLNQIKNPIEKHAAHGVPIKDYEGKNSIIAKIRTHNSEVEEEDMDKHLQKARFTKQPAYTLVER 1180

Human  1182 EEKPPNGTPTKHPNWTNKQDNRDLESAQSLNRMEYIV 1218
            ||:.||    |:|||||||||||||:|||||||||||
Zfish  1181 EERAPN----KNPNWTNKQDNRDLETAQSLNRMEYIV 1213

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JAG1NP_000205.1 MNNL 32..185 CDD:462222 112/153 (73%)
DSL 167..229 CDD:128366 48/61 (79%)
Important for interaction with NOTCH1. /evidence=ECO:0000269|PubMed:18660822 199..207 6/7 (86%)
EGF_CA 296..334 CDD:238011 34/37 (92%)
EGF 340..370 CDD:394967 19/29 (66%)
EGF_CA 374..410 CDD:238011 29/35 (83%)
EGF_CA 412..447 CDD:238011 27/34 (79%)
EGF_CA 450..485 CDD:238011 24/34 (71%)
EGF_CA 487..523 CDD:238011 27/35 (77%)
EGF_CA 525..560 CDD:238011 30/34 (88%)
EGF_CA 629..665 CDD:238011 29/35 (83%)
EGF_CA 667..702 CDD:238011 26/34 (76%)
EGF 748..777 CDD:394967 25/28 (89%)
EGF_CA 782..817 CDD:238011 32/34 (94%)
EGF_CA 820..856 CDD:238011 29/35 (83%)
VWC_out 863..930 CDD:214565 37/66 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1152..1218 53/65 (82%)
jag1bNP_571938.2 MNNL 29..182 CDD:462222 112/153 (73%)
DSL 164..226 CDD:128366 48/61 (79%)
EGF_CA 293..331 CDD:238011 34/37 (92%)
EGF 337..365 CDD:394967 18/27 (67%)
EGF_CA 371..407 CDD:238011 29/35 (83%)
EGF_CA 409..444 CDD:238011 27/34 (79%)
EGF_CA 447..482 CDD:238011 24/34 (71%)
EGF_CA 484..520 CDD:238011 27/35 (77%)
EGF_CA 522..557 CDD:238011 30/34 (88%)
EGF_CA 626..662 CDD:238011 29/35 (83%)
EGF_CA 664..699 CDD:238011 26/34 (76%)
EGF 706..736 CDD:394967 24/29 (83%)
EGF 745..775 CDD:394967 26/29 (90%)
EGF_CA 779..814 CDD:238011 32/34 (94%)
EGF_CA 817..853 CDD:238011 29/35 (83%)
VWC_out 860..927 CDD:214565 37/66 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1202 17/24 (71%)

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