DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JAG1 and jag1

DIOPT Version :9

Sequence 1:	NP_000205.1	Gene:	JAG1 / 182	HGNCID:	6188	Length:	1218	Species:	Homo sapiens
Sequence 2:	XP_002931784.1	Gene:	jag1 / 100486874	XenbaseID:	XB-GENE-485662	Length:	1218	Species:	Xenopus tropicalis

Alignment Length:	1221	Identity:	1028/1221 - (84%)
Similarity:	1118/1221 - (91%)	Gaps:	6/1221 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRSPRTRGRSGRPLS--LLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGD 63
            ||.|| |......||  |::|||| ||.||..||||||||||||||.|||||:||||.|.|||.|
Frog     1 MRFPR-RALFFSALSFRLIIALLC-LRLKVSIASGQFELEILSMQNPNGELQSGNCCDGQRNPTD 63

Human    64 RKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAW 128
            |||:|||||||||||||||||||:|||.||||:|.|||||||:||||.||.|:||||||||||||
Frog    64 RKCSRDECDTYFKVCLKEYQSRVSAGGACSFGTGYTPVIGGNSFNLKYSRNNERNRIVLPFSFAW 128

Human   129 PRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYG 193
            ||||||:|||||.:|||..|..:|:||.|||||||||||||||||.|:.||||||||.||::|||
Frog   129 PRSYTLVVEAWDYNNDTNDPGDLIDKALHSGMINPSRQWQTLKQNAGMTHFEYQIRVICDEHYYG 193

Human   194 FGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQ 258
            |||||||||||||||||.|||||||||:|||||||||:||||||||.|||:||.||:||||||||
Frog   194 FGCNKFCRPRDDFFGHYTCDQNGNKTCLEGWMGPECNKAICRQGCSSKHGTCKTPGECRCQYGWQ 258

Human   259 GLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCS 323
            |.||||||||||||||.|||||||||||||||||||||||||||:||||||||||||||||||||
Frog   259 GQYCDKCIPHPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTYQPCLNGGTCSNTGPDKYQCS 323

Human   324 CPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGT 388
            |||||||.||||||||||||||||.|||.|||:||||:|:.||||||||.|||:||||.|.:|||
Frog   324 CPEGYSGLNCEIAEHACLSDPCHNGGSCLETSVGFECQCARGWTGPTCSINIDECSPNPCGYGGT 388

Human   389 CQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININD 453
            |||||:||||:||.||||||||:|||||||||||||.||:|||.||||:|||||.||||||||||
Frog   389 CQDLVDGFKCICPSQWTGKTCQIDANECEAKPCVNANSCRNLIGSYYCNCLPGWTGQNCDININD 453

Human   454 CLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFS 518
            |||||||..:|||||||:||||||||||:.||:|::||.|||||||||||:|||.||||||.|||
Frog   454 CLGQCQNGGTCRDLVNGFRCICPPGYAGERCEKDVNECVSNPCLNGGHCQDEINGFQCLCPAGFS 518

Human   519 GNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMA 583
            |||||||||||||:||||||||:|.|:||||.|.|||||||||||||||||||||||||||||:|
Frog   519 GNLCQLDIDYCEPDPCQNGAQCFNLATDYFCNCSEDYEGKNCSHLKDHCRTTPCEVIDSCTVAVA 583

Human   584 SNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
            ||.|||||||||||||||||||:|||||||||:||||||||||||||||||||||:|||||||||
Frog   584 SNSTPEGVRYISSNVCGPHGKCRSQSGGKFTCECNKGFTGTYCHENINDCESNPCKNGGTCIDGV 648

Human   649 NSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEAT 713
            |||||||||||||.||||||||||:|||:||||||||||||||:|||||||||||||||||||||
Frog   649 NSYKCICSDGWEGIYCETNINDCSKNPCYNGGTCRDLVNDFYCECKNGWKGKTCHSRDSQCDEAT 713

Human   714 CNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPI 778
            ||||||||||||.|||:||.||||.|||||||||||||||.|||||||.|:|||||||||||||.
Frog   714 CNNGGTCYDEGDTFKCICPAGWEGATCNIARNSSCLPNPCFNGGTCVVRGDSFTCVCKEGWEGPT 778

Human   779 CAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYR 843
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||
Frog   779 CSQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCIDEINGYR 843

Human   844 CVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGH 908
            |.||||.||.:||||:||||||.|.::|||||||||||:||||||::.||||||||:.|.:| |.
Frog   844 CTCPPGRSGPRCQEVTGRPCITNGHMMPDGAKWDDDCNSCQCLNGKVTCSKVWCGPQRCDIH-GS 907

Human   909 SECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQD-NCANITFTFNKEMMSP 972
            ||||:||:|:||.|:.|||.||||||||..::..||||||.:::.||| :|||||||||||||||
Frog   908 SECPAGQTCVPIRDNHCFVPPCTGVGECWPTNQPPVKTKCNANASYQDASCANITFTFNKEMMSP 972

Human   973 GLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIID 1037
            |||||.||:|||||||||||||||||||.||.|||||||||||||.|:..|..||:|:||::|||
Frog   973 GLTTESICNELRNLNILKNVSAEYSIYITCELSPSANNEIHVAISVEENGDGRNPVKDITERIID 1037

Human  1038 LVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSH 1102
            ||||||.|::.||:|||||||||..||.||||||||||:|||||:||||||||||:|||||..||
Frog  1038 LVSKRDANNTFIASVAEVRVQRRQAKNGTDFLVPLLSSILTVAWVCCLVTAFYWCIRKRRKQSSH 1102

Human  1103 THSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQK 1167
            :|:||||||||||||||||||||||||||||||||||||||||::||||||||||||||||||||
Frog  1103 SHTASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKIAKIRTHNSEVEEDDMDKHQQK 1167

Human  1168 ARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQDNRDLESAQSLNRMEYIV 1218
            .|:.||||||||||:|||||.||:|.|||||||||||||:|||||||||||
Frog  1168 PRYVKQPAYTLVDRDEKPPNSTPSKQPNWTNKQDNRDLETAQSLNRMEYIV 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAG1	NP_000205.1	MNNL	32..106	CDD:284966	63/73 (86%)
		DSL	167..229	CDD:279722	53/61 (87%)
		Important for interaction with NOTCH1. /evidence=ECO:0000269\|PubMed:18660822	199..207		7/7 (100%)
		EGF_CA	296..334	CDD:238011	35/37 (95%)
		EGF	340..370	CDD:278437	23/29 (79%)
		EGF_CA	374..410	CDD:238011	28/35 (80%)
		EGF_CA	412..447	CDD:238011	29/34 (85%)
		EGF_CA	450..485	CDD:238011	28/34 (82%)
		EGF_CA	487..523	CDD:238011	29/35 (83%)
		EGF_CA	525..560	CDD:238011	28/34 (82%)
		EGF_CA	629..665	CDD:238011	33/35 (94%)
		EGF_CA	667..702	CDD:238011	31/34 (91%)
		EGF	748..777	CDD:278437	25/28 (89%)
		EGF_CA	782..817	CDD:238011	34/34 (100%)
		EGF_CA	820..856	CDD:238011	30/35 (86%)
		VWC_out	863..930	CDD:214565	45/66 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1152..1218		57/65 (88%)
jag1	XP_002931784.1	MNNL	32..107	CDD:369454	64/74 (86%)
		DSL	167..229	CDD:366627	53/61 (87%)
		EGF_CA	296..334	CDD:238011	35/37 (95%)
		EGF	340..370	CDD:333761	23/29 (79%)
		EGF_CA	374..410	CDD:238011	28/35 (80%)
		EGF_CA	412..447	CDD:238011	29/34 (85%)
		EGF_CA	450..485	CDD:238011	28/34 (82%)
		EGF_CA	487..523	CDD:238011	29/35 (83%)
		EGF_CA	525..560	CDD:238011	28/34 (82%)
		EGF_CA	629..665	CDD:238011	33/35 (94%)
		EGF_CA	667..702	CDD:238011	31/34 (91%)
		EGF	709..739	CDD:333761	26/29 (90%)
		EGF	748..778	CDD:333761	26/29 (90%)
		EGF_CA	782..817	CDD:238011	34/34 (100%)
		EGF_CA	820..856	CDD:238011	30/35 (86%)
		VWC_out	863..929	CDD:214565	45/66 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	624	1.000	Domainoid score	I2194
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H180
Inparanoid	1	1.050	2341	1.000	Inparanoid score	I459
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45993
OrthoDB	1	1.010	-	-		D15794at32523
OrthoFinder	1	1.000	-	-		FOG0003067
OrthoInspector	1	1.000	-	-		oto159638
Panther	1	1.100	-	-	LDO	PTHR24044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6119
SonicParanoid	1	1.000	-	-		X2046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110