DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nsd1 and pps

DIOPT Version :9

Sequence 1:NP_032765.3 Gene:Nsd1 / 18193 MGIID:1276545 Length:2691 Species:Mus musculus
Sequence 2:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster


Alignment Length:2731 Identity:495/2731 - (18%)
Similarity:815/2731 - (29%) Gaps:1094/2731 - (40%)


- Green bases have known domain annotations that are detailed below.


Mouse   167 SEMDPEQPVTEDESIEEI--FEETQTNATCNYEPKSENGVEVAMGSEQDSMPESRHGA------- 222
            |.:|.|    |||.:||:  |.||.|::..:.:..|::|.:.|  ||.|...|..|..       
  Fly    62 SMVDQE----EDERLEELANFMETATDSELDSDNGSQSGGDNA--SEMDEHDEENHNTGDDNNSD 120

Mouse   223 ---VERPFLPLAPQTEK--------------QKNKQRSEVDGSN-------------EKTALLPA 257
               .|..    ||:|.|              :|.|:|.::.|..             .|.||..|
  Fly   121 STETEAD----APRTRKRVGRKPKAIKKRKRRKPKERPQIVGLRVEQFYADNTADMVVKNALKLA 181

Mouse   258 PTSL----GDTNVTVEEQFNSINLSFQDDPDSSPSPLGN------------------MLEIPGTS 300
            ..|:    .:|:..:|...|..|.:    |.:||..|.|                  :::.||  
  Fly   182 GVSVYKRTAETDALMEVIRNDHNYT----PFTSPEQLKNHKRDEKMAMEMQAQSRKIIMQAPG-- 240

Mouse   301 SPSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVANRRPYREY 365
                |.:|...:.:.::.||     ..:..|.:|.|           :..|...:.|..:|..:.
  Fly   241 ----SVKLINAKKRVQAIPL-----SPVQVKVQRLP-----------VKPHQVQQAAQLQPKVQL 285

Mouse   366 YVEAFGDP---SEKAWVAGKAIVMFEGRHQFEELPVLRKRGKQKEKGYRHKVPQKILSKWEA-SV 426
            ..:....|   .:...:|..::   ..|.:....||         |.....|.:.|....:| |.
  Fly   286 IRKPIHSPLPRQKPEIIANNSV---NARLRPTRAPV---------KVIAPPVQEYIEDDDDAQSS 338

Mouse   427 GLAEQYDVPKGSKNQKCVSSSVKLDSEEDMPFEDCTNDPDSEHLLLNGCLKSLAFDSEHSADEKE 491
            ..||:.:..|...:::.        |||...|::..||.||:          :.||..||  .:.
  Fly   339 DSAEEENADKAYDSEEM--------SEESDEFQESDNDRDSD----------MDFDMRHS--NRR 383

Mouse   492 KPCAKSRVRKSSDNIKRTSVK--KDLVP----------FESRKEERRGKIPDNLGLDFISGGVSD 544
            .|..:.||||.   :::|..|  |.|.|          .:.|||....|.|              
  Fly   384 NPNKRKRVRKV---VRQTPSKPMKPLPPPPTTPQHFPELKKRKEVLEPKAP-------------- 431

Mouse   545 KQASNELSRIANSLTGSSTAPGSFLFSSSVQNTAKTDFETPDCDSLSGLSESALISKHSGEKKKL 609
                 ::.:|. .:..:.:.|..|.....:.:|:..... |...||. :....|.:..:....:.
  Fly   432 -----QIGQII-QMPATKSVPAVFALGRGLPSTSFLKIR-PTHQSLP-VKRPPLPTTPANSNVRR 488

Mouse   610 QPGQVCSSKVQLCYVGAGDEEKRSNSVSVSTTSDDGC-SDLDPTEHNSGFQNSVLGITDAFDKTE 673
            .|.      |||..:....:|.:...::.:..|..|. ::|          |::||      :..
  Fly   489 MPA------VQLGRIVNSPQEVKEIIINKNMASPKGVFTNL----------NTLLG------EDN 531

Mouse   674 NALSVHKNETQYSRYPVTNRIKEKQKSLITNSHADHLMGSTKTMEPETAELSQVNLSDLKISSPI 738
            ||      .|:.|..|:.:|                     ..|.|.|.. |..|.....|..|:
  Fly   532 NA------ATKSSPVPLRHR---------------------AVMSPSTPR-SSYNQQMSPIVVPV 568

Mouse   739 P----KPQPEFRNDGLTTKFSAPPGIRNENPLTKGGLANQTLLPLKCRQPKFRSIKCKHKESPA- 798
            |    .|...|...|:.|..|                                     || .|| 
  Fly   569 PAQAHTPSKGFMPIGVDTAQS-------------------------------------HK-LPAQ 595

Mouse   799 -VAETSATSEDLSLKCCSSDTNGSPLANISKSGKGEGLKLLNNMHEKTRDSSDIE-TAVVKHVLS 861
             |.||..:|.:|:.:      |...|..|:...:.|.||  :.:.|:...::|.: ..:||.:.|
  Fly   596 IVIETHQSSSELAAE------NDKQLDLINSIVQDELLK--STLVEQPVVNADEDIPKLVKMLES 652

Mouse   862 ELKELSYRSLS--------EDVSDSGTAKASKPLLFSSASSQNHIP----------IEPDYKFST 908
            ...:|....:|        .::...|.|.|:.|......::::.|.          ||.|.:|  
  Fly   653 TAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQF-- 715

Mouse   909 LLMMLKDMHDSKTKEQRLMTAQNLASYRTPDRGDCSSGSPVGTSKVLVLGSSTPNSEKPGDSTQD 973
                           :..:..|.|||            :..||...:|   |.|.|.:|.|..|.
  Fly   716 ---------------EAEVVKQVLAS------------TEPGTLDAIV---SMPTSIEPVDVPQV 750

Mouse   974 SVHQS--PGGGDSALSGELSSSLSSLASDKRELP-ACGKIRSNCIPRRNCGRAKPSSKLRETISA 1035
            ..|.:  |           ::||:..|.....|| ||.      .|.|:...:.|.:      ||
  Fly   751 QAHTNLLP-----------NASLTEPAQSMTSLPIACS------TPSRSVAASTPPT------SA 792

Mouse  1036 QMVK--------PSVNPKALKTERKRKFSRLPAV-TLAANRLGNKESG------SVNGPSR---- 1081
            ::|:        |.:.....:.:|:.:|...|.: ..:::..||...|      |:|.|..    
  Fly   793 KVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSL 857

Mouse  1082 -------GGAEDPGKEEPLQQMDLLRNEDTHFSDVHFDSKAKQSDPDKNLEKEPSFENRKGPELG 1139
                   .|.:.|...||                    |.|::|...:..:|..:.:| ..|: .
  Fly   858 SNDSQPGSGPKRPNPREP--------------------SMARRSTAPRRSKKLDASQN-NDPD-A 900

Mouse  1140 SEMNTENDELHGVNQVVPKKRWQRLNQRRPKPGKRANRFREKENSEGAFGVLLPADAVQKAREDY 1204
            ||...::|:        |.|.|....|      ...|||            ::..|..    ||:
  Fly   901 SESQEDDDD--------PNKLWCICRQ------PHNNRF------------MICCDLC----EDW 935

Mouse  1205 LEQRAPPTSKPEDSAADPNHGSHSESVAPRLNVCEKSSVGMGDVEKETGIPSLMPQTKLPEPAIR 1269
            .                  ||:           |...:..||...:..||               
  Fly   936 F------------------HGT-----------CVGVTKAMGTDMENKGI--------------- 956

Mouse  1270 SEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEDESLLARCQPSAQNKQ-VDE 1333
                      .|               |..|.|:.|..:...|..| .|:.|  |:.|.:| ..|
  Fly   957 ----------DW---------------KCPKCVKRQEERSQPRITD-MLVTR--PTTQPEQRPSE 993

Mouse  1334 NSLISTKEEPPVLEREAPFLEGPLAQSDLGVTHAELPQLTLSVPVAPEASP------RPALESEE 1392
            ..:::|..|  :::..||                ..|:.||.|.:...:||      :||     
  Fly   994 TKVLTTTAE--IVQVAAP----------------SAPRRTLPVVLTVASSPMRIPMAKPA----- 1035

Mouse  1393 LLVKTPGNYESKRQRK----------PTKKLLESNDLDPGFMPKKGDLGLSRKCFE-ASRS---- 1442
              .|.|....|.:|::          |.|::.|:               |...|.. ||.|    
  Fly  1036 --KKFPTGAISHQQQQQLNFIRLGPSPGKRISET---------------LCVVCKRPASTSSVYC 1083

Mouse  1443 GNGIVESRATSHLKEFSGGTTKIFDKPRKRKRQRLVTARVHYKKVKKEDLTKDTPSSEGELLIHR 1507
            |...:...|.|.::..:.....:   |:....|.|:......||.||:||.:|         :.|
  Fly  1084 GEECIRKYAQSAIQAHAATKGPL---PQNAGAQSLLNNSFDAKKNKKKDLFED---------VLR 1136

Mouse  1508 TAASPKEILEEGVEHDPGMSASKKLQV-ERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLEC 1571
            .|.:              :|..:::.| ||..|..:..::..:..:..:.|    |...:|.:  
  Fly  1137 QADT--------------VSKVERINVFERKSGRVITGHMAPSAHQFRKWL----QENPSFEV-- 1181

Mouse  1572 LGLPEMPRGKFICNECHTGIHTCFVCKQSGEDVKRCL--LPLCGKFYHEEC---VQKYPP----- 1626
                 :|.|..                ||.:..||.|  .|.......|..   |.|.||     
  Fly  1182 -----LPSGTV----------------QSADAEKRLLKGAPEAATSTSEPAVLGVAKKPPEGPAK 1225

Mouse  1627 -TVTQNKGFRCPLHICITCHAANPANVSA-------SKGRLMRCVRCPVAYHANDFCLAAGSKIL 1683
             :..||          .|..|::...:|:       .|.:....|:.|....     :|||... 
  Fly  1226 LSHPQN----------TTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNR-----IAAGKPE- 1274

Mouse  1684 ASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGG--------SLLCCDSCPAAFHRECLNIDIP 1740
                   |.....||..|......:.......|..        ::|..|.    |.:   |:::.
  Fly  1275 -------PVRIGIRRSLREQLLARIKEAQAAEENSGQPTTQWPTVLEVDQ----FVK---NVELE 1325

Mouse  1741 EGNWYCNDCKAGKKPHYREIVW-VKVGRYRWWPAEICHPRAVPSNIDKM---------------- 1788
            ..|.:..|..|..|..||.::: :|..:.|....:||..:..|..:.:|                
  Fly  1326 MFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREE 1390

Mouse  1789 --RHDV-----GEFPVLFFGSNDYLWTHQAR---------VFPYMEGDVSSKDKMGKGVDGTYKK 1837
              ||.:     .|..:|....|..:.||:..         ..|  |.:||....|   .|.....
  Fly  1391 ENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLP--EENVSEASSM---ADTKQTS 1450

Mouse  1838 ALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATD 1902
            .:.|.:....|....:|.....:::::  |...:.|.|.:|               .|.|.:.. 
  Fly  1451 LVSEPSTSTLERSTSREKAGSSKEKRH--KSHKHHHRKRSR---------------SRSNSRGR- 1497

Mouse  1903 ENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGE 1967
                .:|..                          .:||:.:    ...|.|.|           
  Fly  1498 ----SVDKR--------------------------HRRQHNE----GGEQPGSG----------- 1517

Mouse  1968 FVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQK 2032
                       |.|.|:|.:.::|            :|.|:                 |:...:|
  Fly  1518 -----------EREHRSREKQSRE------------RDEIV-----------------PSPLPKK 1542

Mouse  2033 WSVNGDTRVGLFALSDIKAGTELTFNYNL--ECLGNGKTV---CKCGAPNCSGFLGVRPKNQPIV 2092
            ...|..:.|   .....:..||.: .|||  :.|.:.|||   ...|.|        :|..:|:.
  Fly  1543 RDENDQSPV---PKKTAEKKTEAS-AYNLVDQILESEKTVEQAANLGKP--------KPSPKPLP 1595

Mouse  2093 TEEKSRK-------FKRKPHGKRRSQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNL 2150
            |...|.|       :.|..||...|                                        
  Fly  1596 TLPSSLKAPEPMDNYSRYLHGLTTS---------------------------------------- 1620

Mouse  2151 TKRPAGKWECPWHQCDVCGKEAASF-----CEMCPSSFCKQHREGMLFISKLD--GRLSCTEHDP 2208
                 ..|.......|:...|...:     |          |:.|.|..|::|  ||::..    
  Fly  1621 -----SLWSGTLKMIDLADFEIVMYPVQGNC----------HQLGNLMPSQMDVIGRITRV---- 1666

Mouse  2209 CGPNPLEPGEIREYVPPTATSPPSPGTQPKEQSSEMATQGPKKSDQPPTDATQLLPLSKKALTGS 2273
                     .:.||:                          ||..:.||....::          
  Fly  1667 ---------NVWEYI--------------------------KKLKKSPTKEVVIV---------- 1686

Mouse  2274 CQRPLLPERPPER---------TDSSSHL------LDRIRDL----AGSGTKSQSLVSSQRPQDR 2319
               .:.|..|.|.         .||...|      .|:|||.    .|||.|            .
  Fly  1687 ---NIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFPLGSGDK------------L 1736

Mouse  2320 PPAKEGPRPQP--PDRASPMT-----------RPSSS-PSVSSLPLERPLRMTDSRLDKSIGAAS 2370
            |||.:...|.|  .:...|.|           ||:.: ||..|:|  .|:....|::.|      
  Fly  1737 PPALQTAEPVPFYEEAQRPNTLLGIIVRCLSKRPADAVPSTPSVP--TPVPALSSKVAK------ 1793

Mouse  2371 PKSQAVEKTPASTGLRLSSPDRLLTTNS-----------------------------PKPQI--- 2403
             :|::....||.     |||.|.::|:|                             |:|.:   
  Fly  1794 -RSRSSISYPAQ-----SSPKRKISTHSTSSKDDEFDIDAIIKAPIAKLQKTAPKVVPQPSVPND 1852

Mouse  2404 SDRP--PEKSHASLT----QRLPPPEKVLSAVVQSLVAKEKAL------RPVDQNTQSKHRPAVV 2456
            :|.|  |..|...|.    ||....|:.::.:.:.:.|::..:      .|....:.|....|:.
  Fly  1853 ADEPYSPGGSDDELVPSAPQRPNDLERQVNEINKQIAAQQMEIAGLLKVEPTGSASSSNVLAAIS 1917

Mouse  2457 M--DLIDLTPRQKERAASP-------QEVTPQADEKTAMLESSSWPSSKG-LGHIPRATEKISVS 2511
            :  :|..:....|::...|       :|..|:.|.......:|..|.||| |.|:..|.....|.
  Fly  1918 IPANLSKILASIKDKTNLPSSADDGDEEYNPEDDITATSSFASKKPRSKGRLAHLSEAELLSMVP 1982

Mouse  2512 ESLQPSGKVAAPSEHPWQAVKSLTHARFLSPPSAKAFLYESATQASGRTPVGAEQTPGPPSPAPG 2576
            ::|  :|.:...|....|..:|.     |:|                 ||:      .||.|.||
  Fly  1983 DNL--AGVIPRSSRTRHQLAQSP-----LTP-----------------TPL------PPPPPPPG 2017

Mouse  2577 L 2577
            :
  Fly  2018 V 2018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nsd1NP_032765.3 MSH6_like 320..430 CDD:99898 17/113 (15%)
TNG2 <1453..1587 CDD:227367 23/134 (17%)
PHD1_NSD1_2 1546..1587 CDD:277118 5/40 (13%)
PHD2_NSD1 1593..1639 CDD:277120 13/56 (23%)
PHD3_NSD1 1640..1693 CDD:277123 10/59 (17%)
PHD4_NSD1 1710..1749 CDD:277126 6/46 (13%)
WHSC1_related 1755..1849 CDD:99899 22/126 (17%)
AWS 1902..1940 CDD:375420 1/37 (3%)
SET_NSD1 1942..2083 CDD:380987 25/145 (17%)
PHD5_NSD1 2121..2163 CDD:277129 1/41 (2%)
C5HCH 2162..2211 CDD:375464 10/55 (18%)
PHA03307 2255..>2576 CDD:223039 82/407 (20%)
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 39/258 (15%)
PHD_PHF3_like 914..963 CDD:277027 17/139 (12%)
BRK 1142..1186 CDD:197800 9/54 (17%)
TFIIS_M 1274..1396 CDD:284835 23/136 (17%)
SPOC 1623..1729 CDD:285043 27/167 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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