DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nr1i2 and EcR

DIOPT Version :9

Sequence 1:	NP_035066.1	Gene:	Nr1i2 / 18171	MGIID:	1337040	Length:	431	Species:	Mus musculus
Sequence 2:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster

Alignment Length:	449	Identity:	118/449 - (26%)
Similarity:	203/449 - (45%)	Gaps:	81/449 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 CEEADSALEEPINVEEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKG 79
            |:...|.......|:||     :|.||||:|:|||:|.:|||||||||||::.::....|.|.:
  Fly   246 CDAKKSKKGPAPRVQEE-----LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGR- 304

Mouse    80 TCEITRKTRRQCQACRLRKCLESGMKKEMIM-SDAAVEQRRALIKRKKREKIEAPPP---GGQGL 140
            .||:....||:||.|||:|||..||:.|.:: .:....:||....:|:::|:...|.   ||.|.
  Fly   305 ACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGS 369

Mouse   141 TEE---QQALIQELMDAQMQTFDTTFSHFKDFRLPAVFHSGCELPEFLQASLLEDPATWSQIMKD 202
            ...   |..:.:|::|...                      ||.|:.....||.|... ::....
  Fly   370 LASGGGQDFVKKEILDLMT----------------------CEPPQHATIPLLPDEIL-AKCQAR 411

Mouse   203 RVPMKISLQLRGEDGSIW---NYQPPSKSDGKEIIP-----------LLPHLADVSTYMFKGVIN 253
            .:|.....||......||   .|:.||:.|.:.|:.           ...|:.:::....:.::.
  Fly   412 NIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVE 476

Mouse   254 FAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTET-------------GTWECGRLAYCF 305
            |||.:..|..:|.||||:|||..:.|:.:||....:|..:             .:::...:|...
  Fly   477 FAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNI 541

Mouse   306 EDPNGGFQKLLLDPLMKFHCMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTL 370
            ||            |:.|...:..:::...||.|:.||.:|| ||||:.:..:|:.:|..:..||
  Fly   542 ED------------LLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTL 593

Mouse   371 KAYI---ECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDSHPFATPLMQELF 426
            :.||   .|......  ..:.|::::|||||::..|..:....::..:......::|::
  Fly   594 RIYILNRHCGDSMSL--VFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIW 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nr1i2	NP_035066.1	NR_DBD_like	37..124	CDD:383039	40/87 (46%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	63..89		6/25 (24%)
		Hinge	105..142		9/40 (23%)
		NR_LBD	140..425	CDD:386099	66/317 (21%)
		Hyperforin binding, agonist. /evidence=ECO:0000250\|UniProtKB:O75469	282..285		1/2 (50%)
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	42/95 (44%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	57/246 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847986
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940