DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ctnnd2 and p120ctn

DIOPT Version :9

Sequence 1:	NP_032755.2	Gene:	Ctnnd2 / 18163	MGIID:	1195966	Length:	1246	Species:	Mus musculus
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	883	Identity:	320/883 - (36%)
Similarity:	447/883 - (50%)	Gaps:	214/883 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse   318 SSAGLS--PIRVTSPPTVQSTISSSPIHQLSSTIGTYAT-----------LSPTKRLVHASEQYS 369
            |:||.|  |:.:|.|..|.:....:| |...:.|.|.:|           |:.|.|.|.|. ||.
  Fly    47 SAAGYSSTPLYITKPTGVGAITKVAP-HCSQNKIETNSTDNSIPDIENHPLATTVRYVQAG-QYE 109

Mouse   370 KHSQELYATATLQRPGSLAAGSRASYSSQHGHLAP-------ELRALQSPEHHIDPI----YEDR 423
            ..|:  |..|      .|..|..:.|:::  .:.|       ....:|:....|.|.    :.|.
  Fly   110 DTSE--YGVA------GLTCGIDSEYTAE--AVVPYCYTSDANYTGIQNTTSSIKPFSGRPFNDN 164

Mouse   424 VYQKPPMRSLSQSQGDPLPPAHTGTFRTSTAPSSP-----GVDSVPLQRTGSQHGPQNAAAATFQ 483
            :           :..:.:..:...||::|.....|     .:::|| ||..             :
  Fly   165 I-----------NGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVP-QRLE-------------E 204

Mouse   484 RASYAAGPASNYADPYRQLQYCASVDSPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPEL 548
            :..|..|..::.....|                                          ||||.|
  Fly   205 KDDYIEGSENDICSTMR------------------------------------------WRDPNL 227

Mouse   549 PEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALR 613
            .|||..|.:...::::||||||||||:.|:..|...|..|||..||.||.:...|:|::||||||
  Fly   228 SEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALR 292

Mouse   614 NLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVL 678
            ||.||:.||:||..:||.|||.|||.||.::.:.|::|||||||||:|||:.||..||.:||..:
  Fly   293 NLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAV 357

Mouse   679 TNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVI 743
            ..:||.|||||:.....     :...|.|.|||:|.|||||||||.||..:|.|:.|.:.||||:
  Fly   358 VCSVIKPHSGWDAVCCG-----ETCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVV 417

Mouse   744 QSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELD--------GLLCGETNGKDTE 800
            ::::..:.|.:||||||||||||||||.       |.:.....|        .::...:.|   |
  Fly   418 RTSIEKNNIGNKTVENCVCILRNLSYRC-------QEVDDPNYDKHPFITPERVIPSSSKG---E 472

Mouse   801 SSGCWGKKKKKKKSQDQWDGVGPLPDCAEPP----------KGIQMLWHPSIVKPYLTLLSECSN 855
            :.||:|..||||::.:. |.:......|:..          ||.:.||.|.:|:.||:||..|||
  Fly   473 NLGCFGTNKKKKEANNS-DALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSN 536

Mouse   856 PDTLEGAAGALQNLAAGSWKGWAEDVAGMAYALRSLPEGAPCLPQWSVYIRAAVRKEKGLPILVE 920
            |:|||.||||:|||:|..|                         |.|:.|||.||||||||||||
  Fly   537 PETLEAAAGAIQNLSACYW-------------------------QPSIDIRATVRKEKGLPILVE 576

Mouse   921 LLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNSGSKAMSDDTVTAVC 985
            |||::.|||||||||||||:|:|.|||||||||||||||.:||.||..::..:   ||||:|||.
  Fly   577 LLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNT---SDDTITAVL 638

Mouse   986 CTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKD 1050
            .|::|||.||.|.:::|.|:|||::|:.|:|.| :|::..|:|.|||||.:|||:.:||.:|||:
  Fly   639 ATINEVIKKNPEFSRSLLDSGGIDRLMNITKRK-EKYTSCVLKFASQVLYTMWQHNELRDVYKKN 702

Mouse  1051 GWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYESAG 1115
            ||.:..||:          :.:::..||..||..|   |.:.:.|.:       .:.:|.||.
  Fly   703 GWKEQDFVS----------KHFTAHNTPPSSPNNV---NNTLNRPMA-------SQGRTRYED-- 745

Mouse  1116 NNATYHGTKGEHTSRKDTMTAQNTGVSTLY--RNSYGA 1151
                              .|.|. |.||||  .:|.||
  Fly   746 ------------------RTIQR-GTSTLYSANDSSGA 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctnnd2	NP_032755.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..308
		ARM 1	390..432		7/52 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..479		8/55 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..532		0/18 (0%)
		ARM 2	536..575		18/38 (47%)
		ARM	540..662	CDD:237987	65/121 (54%)
		armadillo repeat	548..573	CDD:293788	12/24 (50%)
		ARM 3	578..617		19/38 (50%)
		armadillo repeat	581..617	CDD:293788	19/35 (54%)
		ARM 4	622..662		23/39 (59%)
		armadillo repeat	625..660	CDD:293788	20/34 (59%)
		armadillo repeat	667..718	CDD:293788	20/50 (40%)
		ARM 5	678..720		17/41 (41%)
		ARM 6	724..769		23/44 (52%)
		ARM 7	831..871		24/49 (49%)
		armadillo repeat	834..871	CDD:293788	22/36 (61%)
		ARM	835..962	CDD:237987	74/126 (59%)
		ARM 8	903..942		31/38 (82%)
		armadillo repeat	906..940	CDD:293788	29/33 (88%)
		ARM	907..1039	CDD:237987	82/131 (63%)
		armadillo repeat	947..993	CDD:293788	27/45 (60%)
		ARM 9	996..1039		19/42 (45%)
		armadillo repeat	999..1034	CDD:293788	15/34 (44%)
		CAF20	<1050..1109	CDD:293657	11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1063..1130		10/66 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1151..1175		1/1 (100%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	61/113 (54%)
		armadillo repeat	227..252	CDD:293788	12/24 (50%)
		armadillo repeat	260..296	CDD:293788	19/35 (54%)
		armadillo repeat	304..339	CDD:293788	20/34 (59%)
		ARM	307..442	CDD:237987	73/139 (53%)
		armadillo repeat	347..392	CDD:293788	19/49 (39%)
		armadillo repeat	515..556	CDD:293788	24/65 (37%)
		ARM	516..643	CDD:237987	86/154 (56%)
		armadillo repeat	562..596	CDD:293788	29/33 (88%)
		armadillo repeat	601..641	CDD:293788	26/42 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6347
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55574
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1889
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	1	1.000	-	-		FOG0006320
OrthoInspector	1	1.000	-	-		otm43460
orthoMCL	1	0.900	-	-		OOG6_104813
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900