DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C18B12.4 and ETP1

DIOPT Version :9

Sequence 1:	NP_510498.1	Gene:	C18B12.4 / 181600	WormBaseID:	WBGene00007666	Length:	456	Species:	Caenorhabditis elegans
Sequence 2:	NP_011853.1	Gene:	ETP1 / 856376	SGDID:	S000001002	Length:	585	Species:	Saccharomyces cerevisiae

Alignment Length:	285	Identity:	64/285 - (22%)
Similarity:	105/285 - (36%)	Gaps:	85/285 - (29%)

- Green bases have known domain annotations that are detailed below.

Worm   209 LCVRGCVERRKLNKRRLSKRN----------LKKIPVKKYRLGDDPDTCAICLESFASGEK-LRH 262
            :.|:..|.::||.:|..:..:          :||   ||..:..:..||.:|||...|... |..
Yeast   195 ISVKEIVFQKKLFQRPAANEDFPYLLTDPFTVKK---KKELVKVELPTCPVCLERMDSETTGLVT 256

Worm   263 LPCRHVFHCNCIDVWLTQTRKICPLCKR---KIGTDS-------DSEC----STNDLASTSQGPN 313
            :||:|.|||.|::.|....   ||:|:.   ::..:|       .:.|    ||::|.......|
Yeast   257 IPCQHTFHCQCLNKWKNSR---CPVCRHSSLRLSRESLLKQAGDSAHCATCGSTDNLWICLICGN 318

Worm   314 DATALYNNADNQSGFELPV----------------------------PQGQMV-----------D 339
            .....||:......:|..:                            ..|::|           |
Yeast   319 VGCGRYNSKHAIKHYEETLHCFAMDIRTQRVWDYAGDNYVHRLVQNEVDGKLVEVGGSGDDDNND 383

Worm   340 LWSSQEALVDQDIVLHNTTRRSITGFVRNAFRK----LRNSPRHRDVDVHSGLEGGSYLVRQQTT 400
            :.:|.|.   |::|..|   ||..|...|:.:|    ..|..|||:..    ||....|: .|..
Yeast   384 IGNSDEL---QNVVYGN---RSKNGEKSNSNKKDGELAANFLRHREYH----LEYVQVLI-SQLE 437

Worm   401 SNDNDHLLENEVSDPTSSSELNIPS 425
            |....:.|:.:..|.|:|...|:.|
Yeast   438 SQREYYELKLQEKDQTASDSSNVES 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C18B12.4	NP_510498.1	PA	<74..176	CDD:333703
		HRD1	<223..>335	CDD:227568	32/164 (20%)
		RING-H2_RNF103	246..291	CDD:319387	18/48 (38%)
ETP1	NP_011853.1	RRM_ETP1	114..201	CDD:410116	1/5 (20%)
		RING-H2_BRAP2	238..281	CDD:319371	18/45 (40%)
		zf-UBP	301..363	CDD:396634	8/61 (13%)
		Smc	409..>534	CDD:224117	16/59 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910