DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C18B12.4 and IRC20

DIOPT Version :9

Sequence 1:	NP_510498.1	Gene:	C18B12.4 / 181600	WormBaseID:	WBGene00007666	Length:	456	Species:	Caenorhabditis elegans
Sequence 2:	NP_013348.1	Gene:	IRC20 / 850949	SGDID:	S000004237	Length:	1556	Species:	Saccharomyces cerevisiae

Alignment Length:	167	Identity:	38/167 - (22%)
Similarity:	70/167 - (41%)	Gaps:	35/167 - (20%)

- Green bases have known domain annotations that are detailed below.

Worm   220 LNKRRLSKRNLKKIPVKKYRLGDDPD-TCAICLESFASGEKLRHLPCRHVFHCNCIDVWLTQTRK 283
            :..|.:..:||.::   |..|.|:.. :|:|||.....|..::   |.|.|..:||..||....|
Yeast  1214 IESRLIYLKNLSRL---KDTLNDNQILSCSICLGEVEIGAIIK---CGHYFCKSCILTWLRAHSK 1272

Worm   284 ICPLCKRKIGTDSDSECSTNDLASTSQGPNDATALYNNADNQSGFELPVPQGQMVDLWSSQEALV 348
             ||:||        ..||.:::.:..         :.|:..:...|:..|:.:..|  |||:...
Yeast  1273 -CPICK--------GFCSISEVYNFK---------FKNSTEKREKEIQEPRREGAD--SSQDNSN 1317

Worm   349 DQDIVLHNTTRRSITGFVRNAFRKLRNSPRHRDVDVH 385
            :..|:.:.:....:.|   |.:.:.     |:..:||
Yeast  1318 ENSIISNMSEVEKLFG---NKYEQF-----HQINEVH 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C18B12.4	NP_510498.1	PA	<74..176	CDD:333703
		HRD1	<223..>335	CDD:227568	28/112 (25%)
		RING-H2_RNF103	246..291	CDD:319387	17/44 (39%)
IRC20	NP_013348.1	HepA	172..>568	CDD:223627
		DEXQc_SHPRH	383..602	CDD:350828
		RAD18	1234..>1327	CDD:227719	27/115 (23%)
		RING-HC_RNF10	1239..1276	CDD:319450	15/40 (38%)
		SF2_C_SNF	1356..1485	CDD:350180
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910