DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C18B12.4 and Rnf167

DIOPT Version :9

Sequence 1:	NP_510498.1	Gene:	C18B12.4 / 181600	WormBaseID:	WBGene00007666	Length:	456	Species:	Caenorhabditis elegans
Sequence 2:	NP_081721.1	Gene:	Rnf167 / 70510	MGIID:	1917760	Length:	347	Species:	Mus musculus

Alignment Length:	282	Identity:	89/282 - (31%)
Similarity:	135/282 - (47%)	Gaps:	26/282 - (9%)

- Green bases have known domain annotations that are detailed below.

Worm    52 NFGMDVSDF------IISEENL-GCGVGVEPVDACGPVRIAQNHTTRCHNLFAFVSRSNISHPCK 109
            |..||.:|.      .:|:|.| |..|...|.:||||:....:.........|.:.|.:    |.
Mouse    33 NASMDFADLPALFGATLSDEGLQGFLVEAHPENACGPIAPPPSAPVNGSVFIALLRRFD----CN 93

Worm   110 FSHQAFMVQNSTYPFRLVIFYNYPGQEPISM--EGTELRDKVNIPVLMISHACKEEIAKKFSDTA 172
            |..:....|.:.|...:|  :|....|.::|  ...|::.::.||.:.|.....|.:...|....
Mouse    94 FDLKVLNAQKAGYGAAVV--HNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSAEYLRALFVYEK 156

Worm   173 GYRLRVRIDPGYYELFRYLIPFLVVI---VFCFALFLITLCVRGCVERRKLNKRRLSKRNLKKIP 234
            |.|: :.:....:.|..|||||..::   |......||..|::   .|::|.:.||:|..||:||
Mouse   157 GARV-LLVPDNSFPLGYYLIPFTGIVGLLVLAMGTVLIVRCIQ---HRKRLQRNRLTKEQLKQIP 217

Worm   235 VKKYRLGDDPDTCAICLESFASGEKLRHLPCRHVFHCNCIDVWLTQTRKICPLCKRKIGT---DS 296
            ...|:.||:.|.|||||:.:..|:|||.|||.|.:|..|:|.|||||||.||:||:.:..   |.
Mouse   218 THDYQKGDEYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDE 282

Worm   297 DSECSTNDLASTSQG-PNDATA 317
            :.|..|.:.....:| |.|..|
Mouse   283 EQEEETQEQEEGDEGEPRDQPA 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C18B12.4	NP_510498.1	PA	<74..176	CDD:333703	22/103 (21%)
		HRD1	<223..>335	CDD:227568	45/99 (45%)
		RING-H2_RNF103	246..291	CDD:319387	27/44 (61%)
Rnf167	NP_081721.1	PA_C_RZF_like	20..170	CDD:239038	32/143 (22%)
		zf-RING_2	228..272	CDD:290367	26/43 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..347		9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I6375
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41046
Inparanoid	1	1.050	139	1.000	Inparanoid score	I3518
Isobase	1	0.950	-	0	Normalized mean entropy	S4419
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm16836
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.670