DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C18B12.4 and RNF167

DIOPT Version :9

Sequence 1:	NP_510498.1	Gene:	C18B12.4 / 181600	WormBaseID:	WBGene00007666	Length:	456	Species:	Caenorhabditis elegans
Sequence 2:	NP_001357232.1	Gene:	RNF167 / 26001	HGNCID:	24544	Length:	374	Species:	Homo sapiens

Alignment Length:	306	Identity:	88/306 - (28%)
Similarity:	132/306 - (43%)	Gaps:	50/306 - (16%)

- Green bases have known domain annotations that are detailed below.

Worm    52 NFGMDVSDF------IISEENL-GCGVGVEPVDACGPVRIAQNHTTRCHNLFAFVSRSNISHPCK 109
            |..||.:|.      .:|:|.| |..|...|.:||.|:..............|.:.|.:    |.
Human    33 NASMDFADLPALFGATLSQEGLQGFLVEAHPDNACSPIAPPPPAPVNGSVFIALLRRFD----CN 93

Worm   110 FSHQAFMVQNSTYPFRLVIFYNYPGQEPISM--EGTELRDKVNIPVLMISHACKEEIAKKFSDTA 172
            |..:....|.:.|...:|  :|....|.::|  ...|::.::.||.:.|.....|.:...|....
Human    94 FDLKVLNAQKAGYGAAVV--HNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEK 156

Worm   173 GYRLRVRIDPGYYELFRYLIPFLVVI---VFCFALFLITLCVRGCVERRKLNKRRLSKRNLKKIP 234
            |.|: :.:....:.|..|||||..::   |......:|..|::   .|::|.:.||:|..||:||
Human   157 GARV-LLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMIARCIQ---HRKRLQRNRLTKEQLKQIP 217

Worm   235 VKKYR------------------------LGDDPDTCAICLESFASGEKLRHLPCRHVFHCNCID 275
            ...|:                        :||..|.|||||:.:..|:|||.|||.|.:|..|:|
Human   218 THDYQKALNSSMFCPDLILPTCLISSTGFVGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVD 282

Worm   276 VWLTQTRKICPLCKRKIGT---DSDSECSTNDLASTSQG-PNDATA 317
            .|||||||.||:||:.:..   |.|.|..|.......:| |.|..|
Human   283 PWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRDHPA 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C18B12.4	NP_510498.1	PA	<74..176	CDD:333703	21/103 (20%)
		HRD1	<223..>335	CDD:227568	46/123 (37%)
		RING-H2_RNF103	246..291	CDD:319387	27/44 (61%)
RNF167	NP_001357232.1	PA_C_RZF_like	20..170	CDD:239038	31/143 (22%)
		RING-H2_RNF167	252..297	CDD:319711	27/44 (61%)
		RING-H2 finger (C3H2C3-type)	254..295	CDD:319711	25/40 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I6450
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41046
Inparanoid	1	1.050	142	1.000	Inparanoid score	I3469
Isobase	1	0.950	-	0	Normalized mean entropy	S4419
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm15079
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.670