Protein Alignment DRD5 and Drd5

DIOPT Version :10

• Sequence 1: NP_000789.1
• Gene: DRD5 / 1816
• HGNCID: 3026
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_036900.2
• Gene: Drd5 / 25195
• RGDID: 2523
• Length: 475
• Species: Rattus norvegicus
• Alignment Length: 479
• Identity: 395/479 - (82%)
• Similarity: 421/479 - (87%)
• Gaps: 11/479 - (2%)

Human     1 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAI 65
            |||||.|.||.|.:..|.:||||.:|..||  |.||||:|||||.||||||:|||||||||||||
  Rat     1 MLPPGRNRTAQPARLGLQRQLAQVDAPAGS--ATPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAI 63

Human    66 VRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILN 130
            ||||||||.|||:||||||||||||||||||||||||||||||||.|||:|||||||||||||||
  Rat    64 VRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGTFCDIWVAFDIMCSTASILN 128

Human   131 LCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWG--GLDL 193
            ||:|||||||||||||||:||||||:|||||||||||||||||||||||||||:|.|.|  ||
  Rat   129 LCIISVDRYWAISRPFRYERKMTQRVALVMVGLAWTLSILISFIPVQLNWHRDKAGSQGQEGL-- 191

Human   194 PNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 258
               |:|.|||||. ||.:...||||||||||||||||||||||||||||||||||||||||||||
  Rat   192 ---LSNGTPWEEG-WELEGRTENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 252

Human   259 ISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFC- 322
            ||||||||||||||||..|..||.||||||||||||.||||:||||||||||||||||||||||
  Rat   253 ISSLERAAEHAQSCRSRGAYEPDPSLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCS 317

Human   323 SGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETV 387
            ||..|||..|||||||||||:|||||||||||||:||||||||:|||||||||||||.||||:||
  Rat   318 SGDAEGPKTGFPCVSETTFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHFCFRTPVQTV 382

Human   388 NISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAE 452
            ||||||||||||.||||||||||:||:||||:.|:|||..:|||||||.|.||..|:||||..||
  Rat   383 NISNELISYNQDTVFHKEIAAAYVHMIPNAVSSGDREVGEEEEEGPFDHMSQISPTTPDGDLAAE 447

Human   453 SVWELDCEGEISLDKITPFTPNGF 476
            ||||||||.|:||.||:|.|||.|
  Rat   448 SVWELDCEEEVSLGKISPLTPNCF 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD5	NP_000789.1	7tm_GPCRs	41..369	CDD:475119	287/330 (87%)
		TM helix 1	43..67	CDD:410628	21/23 (91%)
		TM helix 2	77..99	CDD:410628	20/21 (95%)
		TM helix 3	114..136	CDD:410628	19/21 (90%)
		TM helix 4	159..175	CDD:410628	15/15 (100%)
		TM helix 5	223..246	CDD:410628	22/22 (100%)
		TM helix 6	295..317	CDD:410628	19/21 (90%)
		TM helix 7	338..363	CDD:410628	22/24 (92%)
Drd5	NP_036900.2	7tm_GPCRs	39..364	CDD:475119	287/330 (87%)
		TM helix 1	41..65	CDD:410628	21/23 (91%)
		TM helix 2	75..97	CDD:410628	20/21 (95%)
		TM helix 3	112..134	CDD:410628	19/21 (90%)
		TM helix 4	157..173	CDD:410628	15/15 (100%)
		TM helix 5	217..240	CDD:410628	22/22 (100%)
		TM helix 6	289..311	CDD:410628	19/21 (90%)
		TM helix 7	333..358	CDD:410628	22/24 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..443		17/27 (63%)