Protein Alignment DRD5 and dop-1

DIOPT Version :10

• Sequence 1: NP_000789.1
• Gene: DRD5 / 1816
• HGNCID: 3026
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_001370620.1
• Gene: dop-1 / 180714
• WormBaseID: WBGene00001052
• Length: 460
• Species: Caenorhabditis elegans
• Alignment Length: 451
• Identity: 144/451 - (31%)
• Similarity: 199/451 - (44%)
• Gaps: 136/451 - (30%)

Human    34 PPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWK 98
            |.||        |.::|||..|.||:||||||:..|.||....|:|:||||||||.|::|||.:.
 Worm     7 PLLG--------LFSVLIILALFGNLLVCAAILWDRSLRKQPENLFLVSLAVSDLLVSVLVMLFA 63

Human    99 AVAEVAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVG 162
            ||.::.||||||.| |..|::|||...||||||||.||:||||.||||..|.|...:|....::.
 Worm    64 AVNDILGYWPFGQFYCQFWISFDITTCTASILNLCAISLDRYWHISRPMVYIRYCNRRRINYVIV 128

Human   163 LAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAI 227
            |.|.:|..|...|:        ...:|.....|||              .....|:..|...|||
 Worm   129 LVWLISAGIGAAPL--------GFGFGSKVTINNL--------------TGLPVCEMRLPLPYAI 171

Human   228 SSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISS----------LERAAEH-----AQSCRSSAA 277
            .||::||::|..:|::.||::|..|:..:|.|.:          ::.|:|.     |.:.:..|.
 Worm   172 GSSMVSFFLPAMVMVILYTKLYLYARKHVRSIKTQLQQATSFLIMQLASEKIREVTAATLKGEAL 236

Human   278 CAPDT-----------------------------------------SLRASI------------- 288
            ..||:                                         |:|.||
 Worm   237 LPPDSPATERTTMTVSRHYSRRSTTTTTTATPRRGDKKTSSQNKVESIRTSIFSKLNFLCPTRFK 301

Human   289 ------------------KKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPC 335
                              ..:.|...||.||||.|:.||||||.:|.:..:.   ||       .
 Worm   302 NQRSPQDPHTPAAHNRSNISDQKARLTLGVIMGTFLVCWLPFFTVNILRAWL---PE-------I 356

Human   336 VSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLL----GCSHFCSRTPVETVNISN 391
            .|..|.....|.|:||||.||:||: ||.||::.|.:::    ||   |...|....:||:
 Worm   357 FSSKTIMAVTWLGYANSSANPLIYSIFNRDFRRAFKKIIVRVFGC---CWEEPDLNKSISS 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD5	NP_000789.1	7tm_GPCRs	41..369	CDD:475119	134/416 (32%)
		TM helix 1	43..67	CDD:410628	13/23 (57%)
		TM helix 2	77..99	CDD:410628	14/21 (67%)
		TM helix 3	114..136	CDD:410628	13/21 (62%)
		TM helix 4	159..175	CDD:410628	4/15 (27%)
		TM helix 5	223..246	CDD:410628	9/22 (41%)
		TM helix 6	295..317	CDD:410628	13/21 (62%)
		TM helix 7	338..363	CDD:410628	12/25 (48%)
dop-1	NP_001370620.1	7tmA_Ap5-HTB1-like	7..391	CDD:320193	137/423 (32%)
		TM helix 1	7..33	CDD:320193	16/33 (48%)
		TM helix 2	41..67	CDD:320193	16/25 (64%)
		TM helix 3	79..109	CDD:320193	19/29 (66%)
		TM helix 4	121..143	CDD:320193	6/29 (21%)
		TM helix 5	166..195	CDD:320193	12/28 (43%)
		TM helix 6	320..350	CDD:320193	15/29 (52%)
		TM helix 7	359..384	CDD:320193	11/24 (46%)