Protein Alignment DRD5 and Drd5

DIOPT Version :10

• Sequence 1: NP_000789.1
• Gene: DRD5 / 1816
• HGNCID: 3026
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_038531.1
• Gene: Drd5 / 13492
• MGIID: 94927
• Length: 478
• Species: Mus musculus
• Alignment Length: 483
• Identity: 397/483 - (82%)
• Similarity: 424/483 - (87%)
• Gaps: 14/483 - (2%)

Human     1 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAI 65
            |||||.||||:..:..|.:||||.:|.||||.  ||||:|||||.||||||:|||||||||||||
Mouse     1 MLPPGRNGTAHRARLGLQRQLAQVDAPGGSAA--PLGPAQVVTAGLLTLLIVWTLLGNVLVCAAI 63

Human    66 VRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILN 130
            ||||||||.|||:||||||||||||||||||||||||||||||||||||:|||||||||||||||
Mouse    64 VRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDIWVAFDIMCSTASILN 128

Human   131 LCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWG--GLDL 193
            ||:|||||||||||||||:||||||:|||||.|||||||||||||||||||||:|.|.|  ||
Mouse   129 LCIISVDRYWAISRPFRYERKMTQRVALVMVALAWTLSILISFIPVQLNWHRDKAGSQGREGL-- 191

Human   194 PNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 258
               |:|.|||||. ||.|...||||||||||||||||||||||||||||||||||||||||||||
Mouse   192 ---LSNETPWEEG-WELDGRTENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 252

Human   259 ISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFC- 322
            ||||||||||||||||..||.||.||||||||||||.|||||||||||||||||||||||||||
Mouse   253 ISSLERAAEHAQSCRSRGACEPDPSLRASIKKETKVFKTLSVIMGVFVCCWLPFFILNCMVPFCS 317

Human   323 SGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETV 387
            ||..:||..|||||||||||:|||||||||||||:||||||||:|||||||||||.|.||||:||
Mouse   318 SGDAQGPRTGFPCVSETTFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHLCFRTPVQTV 382

Human   388 NISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDND---EEEGPFDRMFQIYQTSPDGDP 449
            ||||||||||||.|||:||||||:||:||||:.|:|||..:   |||||||.|.||..|:||||.
Mouse   383 NISNELISYNQDTVFHREIAAAYVHMIPNAVSSGDREVGEEEEAEEEGPFDHMSQISPTTPDGDL 447

Human   450 VAESVWELDCEGEISLDKITPFTPNGFH 477
            .||||||||||.|:||.||:|.|||.||
Mouse   448 AAESVWELDCEEEVSLGKISPLTPNCFH 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD5	NP_000789.1	7tm_GPCRs	41..369	CDD:475119	289/330 (88%)
		TM helix 1	43..67	CDD:410628	21/23 (91%)
		TM helix 2	77..99	CDD:410628	20/21 (95%)
		TM helix 3	114..136	CDD:410628	19/21 (90%)
		TM helix 4	159..175	CDD:410628	14/15 (93%)
		TM helix 5	223..246	CDD:410628	22/22 (100%)
		TM helix 6	295..317	CDD:410628	20/21 (95%)
		TM helix 7	338..363	CDD:410628	22/24 (92%)
Drd5	NP_038531.1	7tm_GPCRs	39..364	CDD:475119	289/330 (88%)
		TM helix 1	41..65	CDD:410628	21/23 (91%)
		TM helix 2	75..97	CDD:410628	20/21 (95%)
		TM helix 3	112..134	CDD:410628	19/21 (90%)
		TM helix 4	157..173	CDD:410628	14/15 (93%)
		TM helix 5	217..240	CDD:410628	22/22 (100%)
		TM helix 6	289..311	CDD:410628	20/21 (95%)
		TM helix 7	333..358	CDD:410628	22/24 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..446		17/29 (59%)