DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment let-4 and Fili

DIOPT Version :9

Sequence 1:NP_510425.2 Gene:let-4 / 181554 WormBaseID:WBGene00002282 Length:773 Species:Caenorhabditis elegans
Sequence 2:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster


Alignment Length:391 Identity:115/391 - (29%)
Similarity:190/391 - (48%) Gaps:22/391 - (5%)


- Green bases have known domain annotations that are detailed below.


 Worm     3 LLLCLLLFSTLLINSTNA-CPGVITQACFC--SEVHSGIVLDCSNSSASGILQIIRTNQAQVGLI 64
            :||.|||...:|...|.| ||    ..|.|  .|.:|..:  |.:::...:...:......:   
  Fly    23 VLLLLLLTLVILPPETTAFCP----SKCQCLGGEANSRAL--CVDAALEDVPIQLNPETKYI--- 78

 Worm    65 QSLTMNQAELVELPPNFFSGLFIRRLDLSQNKIKKIDDAAFAGINPVLEEVVLNHNLIEKVPAAA 129
             :||:|:...:|....|:..|.|  ||||||.|:.:....|. ....|..:.|:.||:..:...|
  Fly    79 -NLTVNRIRTLEFSLPFYMKLEI--LDLSQNIIETLGSKNFE-YQSELRTLNLSRNLVSSLHKHA 139

 Worm   130 LAGLPNLLRLDLSNNSIVEIQEQEIFPNLNKLYDINLGSNKIFSIHTSTFQNVKNSIQTINLGHN 194
            ..||.|||.||||.|.| |........:|..|.:::|.:|.|.|:..:.|:.: |:::.:...:|
  Fly   140 FKGLTNLLLLDLSFNRI-ETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGM-NTLEVLVFRNN 202

 Worm   195 NMTAVPSSAIRGLKQLQSLHLHKNRIEQLDALNFLNLPVLNLLNLAGNQIHELNRQAFLNVPSLR 259
            .:..||:|.:..|..|:||.:..|.:|.:...:|..|..|..|::.||.:.||:..||..:.||:
  Fly   203 RLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLK 267

 Worm   260 YLYLSGNKITKLTAYQFQTFEQLEMLDLTNNEIGAIPANSLSGLKQLRQLYLAH-NKISNISSNA 323
            :|.||.|.:|.:...|......|..|:|..|....:||.:...|..||:|:|:. :.:..|.|.|
  Fly   268 HLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRA 332

 Worm   324 FT-NSSIVVLVLSSN-ELKTLTAGIISGLPNLQQVSFRDNQIKTINRNAFYDAASLVMLDLAKNQ 386
            |. |:.:..|.|::| :|..:...:..|.||:.:|..:.|.::|: .:|.:....|..|.|..|.
  Fly   333 FVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTL-YSAQFPVDQLQKLYLGDNP 396

 Worm   387 L 387
            |
  Fly   397 L 397

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
let-4NP_510425.2 leucine-rich repeat 66..86 CDD:275380 5/19 (26%)
LRR_RI <71..275 CDD:238064 64/203 (32%)
LRR_8 88..146 CDD:290566 23/57 (40%)
leucine-rich repeat 88..111 CDD:275380 8/22 (36%)
leucine-rich repeat 112..135 CDD:275380 7/22 (32%)
leucine-rich repeat 136..160 CDD:275380 10/23 (43%)
LRR_8 156..220 CDD:290566 17/63 (27%)
leucine-rich repeat 161..184 CDD:275380 6/22 (27%)
leucine-rich repeat 186..209 CDD:275380 5/22 (23%)
leucine-rich repeat 210..257 CDD:275380 15/46 (33%)
LRR_RI <250..411 CDD:238064 42/141 (30%)
LRR_8 256..316 CDD:290566 19/60 (32%)
leucine-rich repeat 258..281 CDD:275380 7/22 (32%)
leucine-rich repeat 282..305 CDD:275380 7/22 (32%)
leucine-rich repeat 306..328 CDD:275380 9/23 (39%)
LRR_8 327..387 CDD:290566 15/60 (25%)
leucine-rich repeat 329..350 CDD:275380 4/21 (19%)
leucine-rich repeat 353..400 CDD:275380 9/35 (26%)
leucine-rich repeat 356..376 CDD:275380 4/19 (21%)
leucine-rich repeat 401..419 CDD:275380
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 5/25 (20%)
leucine-rich repeat 98..121 CDD:275380 10/25 (40%)
LRR_8 120..180 CDD:404697 21/60 (35%)
leucine-rich repeat 122..145 CDD:275380 7/22 (32%)
leucine-rich repeat 146..169 CDD:275380 10/23 (43%)
LRR <161..>354 CDD:227223 56/193 (29%)
leucine-rich repeat 170..193 CDD:275380 6/23 (26%)
leucine-rich repeat 194..217 CDD:275380 5/22 (23%)
leucine-rich repeat 218..265 CDD:275380 15/46 (33%)
leucine-rich repeat 266..289 CDD:275380 7/22 (32%)
leucine-rich repeat 290..313 CDD:275380 7/22 (32%)
leucine-rich repeat 314..338 CDD:275380 9/23 (39%)
LRR_8 337..397 CDD:404697 15/60 (25%)
leucine-rich repeat 339..360 CDD:275380 4/20 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
21.960

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