DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment akt-2 and S6k

DIOPT Version :9

Sequence 1:	NP_510357.3	Gene:	akt-2 / 181524	WormBaseID:	WBGene00000103	Length:	528	Species:	Caenorhabditis elegans
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	157/410 - (38%)
Similarity:	232/410 - (56%)	Gaps:	31/410 - (7%)

- Green bases have known domain annotations that are detailed below.

Worm   128 MQEEDTNGNPSGESDVNMD--------ATSTRSDNDFESTVMNIDEPEEVPRKNTVTMDDFDFLK 184
            ::.:|.....|.:..:.:|        ..:...|.:.:.|:...:|... |.|..:...||:..|
  Fly    18 LELQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVN-PGKIKLGPKDFELKK 81

Worm   185 VLGQGTFGKVILCRE---KSSDKLYAIKIIRK-EMVVDRSEVAHTLTENRVLYACVHPFLTLLKY 245
            |||:|.:|||...|:   :.::|.:|:|:::| .:|.::.:.|||..|..:|.|..|||:..|.|
  Fly    82 VLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVY 146

Worm   246 SFQAQYHICFVMEFANGGELFTHLQRCKTFSEARTRFYGSEIILALGYLHHRNIVYRDMKLENLL 310
            :||....:..::|:.:|||||.||:|...|.|..|.||.||||||||:||...|:|||:|.||:|
  Fly   147 AFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENIL 211

Worm   311 LDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGR 375
            ||..||:|:||||||||.|:.|..|.|||||.||:|||::....:.::||||.:|.:|::|:.|.
  Fly   212 LDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGV 276

Worm   376 LPFSAKENGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFFKDV 440
            .||:|:...|..|.|....|..|..|:|||..|:..|::|...:|||:||:||..|....|||.|
  Fly   277 PPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHV 341

Worm   441 DWEATLRKEVEPPFKPNVMSETDTSFFDREFTSMPVQLTPPRRGEELPTVDEEEEL----QANFI 501
            :|:..|.:.:|||.||.:.||.|.|.||..||            .::| ||..::.    .||.|
  Fly   342 NWDDVLARRLEPPIKPLLRSEDDVSQFDTRFT------------RQIP-VDSPDDTTLSESANLI 393

Worm   502 -QFASYYVSGSLERSYDTNR 520
             |..:|.....||..:..||
  Fly   394 FQGFTYVAPSILEDMHRANR 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
akt-2	NP_510357.3	PH_PKB	11..116	CDD:269947
		PH	13..115	CDD:278594
		S_TKc	180..437	CDD:214567	117/260 (45%)
		PKc_like	184..509	CDD:304357	143/333 (43%)
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	144/333 (43%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	143/333 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840