DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment R03G8.3 and CG31933

DIOPT Version :9

Sequence 1:	NP_510174.3	Gene:	R03G8.3 / 181437	WormBaseID:	WBGene00010998	Length:	654	Species:	Caenorhabditis elegans
Sequence 2:	NP_722734.1	Gene:	CG31933 / 326176	FlyBaseID:	FBgn0051933	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	180/745 - (24%)
Similarity:	271/745 - (36%)	Gaps:	201/745 - (26%)

- Green bases have known domain annotations that are detailed below.

Worm    17 LVTGCFAMYLVLLGFTMFSPLLSPQQYLGLYQPISGNIPSKVVMNKSEVEPWDQCELPQYDIWDD 81
            ||.|.....::|....    .|..|.|     ...|.|.:...:|.      |.|.:...|:.:.
  Fly     9 LVLGVILTTIILYALL----FLDTQCY-----ETGGKIHNAFFVNT------DGCRIIAMDVMNP 58

Worm    82 EILPYLNMEVNP---ISNCNKSREPLTFLNNGSWGVVNKKTKLICR------------ARCHTRK 131
            .|..|.:.|...   ...|.......|.:.||.|.:  |.|:.|.|            .:|:.
  Fly    59 TIAKYTDWEWKDKRFYLKCPHQTWFRTEVANGDWYL--KLTRDIDRILQESDLTHDWQIKCYW-- 119

Worm   132 SERYNVIGNW---TYTPGPINCEVVEAVCADGKKDVYGFLHTQV------------------IAT 175
             .|..:.|.|   .|.|.....|...|:     |...|..|.:|                  |..
  Fly   120 -FRIKIKGRWRAKIYGPTMFPLEYPYAL-----KVPKGLRHMRVKCLNTFTNKTLHDDAHFFIQP 178

Worm   176 PP----KQPTVKVSELKNYD-------------VTVIMLDSLSFTQAKRSLLRTISYMTNHMDAV 223
            ||    |:|.   :.||.:|             |.::.|||:|.....|.:.||:.||..:|..|
  Fly   179 PPEKLLKKPP---ATLKYWDGEKHSSGATSPISVMILGLDSVSHLNLLRQMPRTVRYMRQNMSQV 240

Worm   224 LFPYINKVGDNSRPNGAALWFGKSLEKLDRSLFEE---ENVPVDWSHAYMCHVYKDNETSLFKEY 285
            .|...||:|.|:.||..||..|.|..:.:.....:   :|:|:.|                 ||:
  Fly   241 EFWGFNKIGTNTYPNLIALLTGLSAAESEAYWVRQKCMDNLPLIW-----------------KEF 288

Worm   286 QNYGYKTLMAEDWAEGTLNWPNCKGFDKPPIDHLMRPFQNALERANHGEPLTKSHLKNQKYCRED 350
            :..||.|..|||.|..::.:....||.:|..|:.:..|...|........::.:|...::...:.
  Fly   289 KRAGYNTSFAEDMAIYSMFYFGKPGFKRPTTDNNLHDFMVDLYINRQASSVSDTHCMGERAFMDI 353

Worm   351 HHTLLDYLSQFINAYPDQNKFRWIWASILGHDSENGFPHSDKDFHKFLIKHR------EQL---- 405
            ...:.|.|......||..: |.| ||        ||       ||:|....|      |:|
  Fly   354 LLEMNDRLLPHTQRYPFFS-FYW-WA--------NG-------FHEFFNSPRLADGRFERLLRSL 401

Worm   406 ------DNSFVFFMGDHGLRFGNVRKTFVGTLDVSNPFLAVSIPKNLRQTTGL-LNVMRENAQKI 463
                  :|:.:|||.|||||:|..|.:|.|.::.|.|||:|..||.:|....: :..:..||..:
  Fly   402 DDAGITNNTIIFFMSDHGLRWGLFRSSFQGMIEDSQPFLSVLYPKWMRLKYPMAIKSLVGNAHSL 466

Worm   464 QTHFDTRATMLDILKYQSASNFT------DLDPLIIPGEKGYSYIRTQPDIL-----RNCRNMPI 517
            .|.:|...|:..||:..|..:.:      :|..|     ||....|.....|     |||....|
  Fly   467 VTTYDLHETLKHILEPSSLEDTSITQKTEELWKL-----KGSQTPRAVSLFLPIPPWRNCNTSHI 526

Worm   518 PMQYCICQF-----NKTQVSTKSETAKGVGEAVALAVNNEIEEGKFTDKCVKMKVDHVVSLL--- 574
            |.::|:|..     ...:|.|||      ...:...||..:.|   ...|:.:::|.:.|..
  Fly   527 PSKFCLCHKQIPIPESNRVVTKS------ASIIIDYVNQLMVE---YPVCIPLQLDSIESAYFAA 582

Worm   575 -QFDQKF---KG-SMLY---------------TAVVEM-TKPSKAVY-----KANVKILENGE-V 612
             |.|..|   || ..:|               ..||.: |||..|.:     :...|:...|| |
  Fly   583 PQRDDDFYIEKGHKNVYPEKGPFWKKQKYEDRDIVVRLKTKPGNAYFEGMTRRQGSKLSLVGEVV 647

Worm   613 KVLGMVERSNKYGSTAYCIGSEHHRPYCYC 642
            :|.|...|:|.      ||.:....|:|:|
  Fly   648 RVGGEGNRNND------CIDNPLLEPFCHC 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
R03G8.3	NP_510174.3	DUF229	92..570	CDD:281053	138/566 (24%)
R03G8.3	NP_510174.3	ALP_like	190..480	CDD:293745	87/322 (27%)
CG31933	NP_722734.1	DUF229	114..576	CDD:281053	129/520 (25%)
CG31933	NP_722734.1	ALP_like	208..483	CDD:293745	86/308 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28588
OrthoDB	1	1.010	-	-		D306348at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.990