DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Notch4 and Dl

DIOPT Version :9

Sequence 1:	XP_006523861.1	Gene:	Notch4 / 18132	MGIID:	107471	Length:	1968	Species:	Mus musculus
Sequence 2:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster

Alignment Length:	841	Identity:	222/841 - (26%)
Similarity:	304/841 - (36%)	Gaps:	230/841 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    91 SRSPTSPLTPHFSCTCPSGFTGDRCQTHLEELCPP---SFCSNGGHCYVQASGRPQCSCEPGWTG 152
            |.|..:.|...|..||...:.|..|    .:.|.|   ||    ||.....:|  :..|..||.|
  Fly   169 SESQYTSLEYDFRVTCDLNYYGSGC----AKFCRPRDDSF----GHSTCSETG--EIICLTGWQG 223

Mouse   153 EQCQLRDFCSANPCANG---GVCLATYPQIQCRCPPGFEGHTCERDINECFLEPGPCPQGTSCHN 214
                  |:|....||.|   |.|  ..|. ||.|..|::|..|    |||.|||.
  Fly   224 ------DYCHIPKCAKGCEHGHC--DKPN-QCVCQLGWKGALC----NECVLEPN---------- 265

Mouse   215 TLGSYQCLCPVGQEGPQCKLRKGACPPGSCLNGGTCQLVPEGHSTFHLCLCPPGFTGLDCEMNPD 279
                                    |..|:|....|             |:|..|:.||.|..:.:
  Fly   266 ------------------------CIHGTCNKPWT-------------CICNEGWGGLYCNQDLN 293

Mouse   280 DCVRHQ-CQNGATCLD-GLDTYTCLCPKTWKGWDCSEDIDECEARGPPRCRNGGTC---QNTAGS 339
            .|..|: |:||.||.: |...|||.|...:.|.||..:|..|:|...| |:|||||   .:|...
  Fly   294 YCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNP-CQNGGTCIDEPHTKTG 357

Mouse   340 FHCVCVSGWGGAGCEENLDDCAAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHV 404
            :.|.|.:||.|..|||.:           .||.|:                          |||.
  Fly   358 YKCHCANGWSGKMCEEKV-----------LTCSDK--------------------------PCHQ 385

Mouse   405 NAQCSTNPLTGST----LCICQPGYSGSTCHQDLDECQMAQQGPSPCEHGGSCINTPGSFNCLCL 465
            ....:..|..||.    .|.|..||||..|...||.|     .|:||.:||||   ..|..|:|.
  Fly   386 GICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNC-----SPNPCINGGSC---QPSGKCICP 442

Mouse   466 PGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGRLCEVEVNECTSNPCLNQAACH 530
            .|::|:|||.:.::||...|..|.||:|::..:.|.|.||..|..|..:|:.|...||.|...|.
  Fly   443 AGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCL 507

Mouse   531 DLLNGFQCLCLPGFTGARCEKDMDECSSTPCANGGRCRDQPGAFYCECLPGFEGPHCEKE-VDEC 594
            :|.|.:||.|..||||..|..|:|||||.||.|||.|.::..:|.|.|..||.|..|::| .|..
  Fly   508 NLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSV 572

Mouse   595 LSDPCPVGASCLDLPG----------AFFCLCRPGFTGQLCEVPLCTPNMCQPGQQCQGQEHRAP 649
            ..|....||:......          |.|.:..|     |..|.......|...::.:.||
  Fly   573 TFDAHQYGATTQARADGLTNAQVVLIAVFSVAMP-----LVAVIAACVVFCMKRKRKRAQE---- 628

Mouse   650 CLCPDGSPGCVPAEDNCPCHHGHCQRSLCVCDEGWTGPECETELGGCISTPCAHGGTCHPQPSGY 714
                         :|:......:.|.::                           .|.|...||.
  Fly   629 -------------KDDAEARKQNEQNAV---------------------------ATMHHNGSGV 653

Mouse   715 NCTCPAGYMGLTCSEEVTACHSGPCLNGGSCSIRPEGYSCT----CLPSHTGRHCQTAVDHCVSA 775
            .....:..:|     ..|..:||...:||:.:|....:..:    |..:........|.|.|:
  Fly   654 GVALASASLG-----GKTGSNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAADECL-- 711

Mouse   776 SCLNGGTCV-----NKPGTFFCLCATGFQGLHCEEKTNPSC--ADSPCRNKATCQDTPRGARCLC 833
              :.||...     |...:.||:..........:..|:|:.  ..||..:.|      :||
  Fly   712 --MYGGYVASVADNNNANSDFCVAPLQRAKSQKQLNTDPTLMHRGSPAGSSA------KGA---- 764

Mouse   834 SPGYTGSSCQTLIDLCARKPCPHTARCLQSGPSFQCLCLQGWTGALCDFPLSCQKAAMSQG 894
            |.|..|::....|.:..     ..:.|.|..||   |...|..|| |...|....:....|
  Fly   765 SGGGPGAAEGKRISVLG-----EGSYCSQRWPS---LAAAGVAGA-CSSQLMAAASVAGSG 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Notch4	XP_006523861.1	EGF_CA	162..193	CDD:238011	11/33 (33%)
		EGF_CA	195..233	CDD:214542	6/37 (16%)
		EGF_CA	315..354	CDD:238011	16/41 (39%)
		EGF_CA	356..391	CDD:238011	3/34 (9%)
		EGF_CA	433..474	CDD:238011	16/40 (40%)
		EGF_CA	476..512	CDD:238011	12/35 (34%)
		EGF_CA	515..550	CDD:238011	15/34 (44%)
		EGF_CA	552..588	CDD:238011	18/35 (51%)
		EGF_CA	591..626	CDD:238011	8/44 (18%)
		EGF_CA	<700..727	CDD:238011	5/26 (19%)
		EGF_CA	769..804	CDD:238011	7/39 (18%)
		EGF_CA	<814..843	CDD:238011	8/28 (29%)
		EGF_CA	896..928	CDD:238011
		EGF_CA	930..965	CDD:238011
		EGF_CA	970..1004	CDD:238011
		EGF_CA	1006..1044	CDD:238011
		NL	1207..1245	CDD:197463
		Notch	1257..1285	CDD:365847
		Ank_2	<1575..1663	CDD:372319
		ANK repeat	1582..1629	CDD:293786
		ANK repeat	1633..1663	CDD:293786
		Ank_2	1637..1730	CDD:372319
		ANKYR	1644..1819	CDD:223738
		ANK repeat	1665..1697	CDD:293786
		ANK repeat	1699..1730	CDD:293786
		ANK repeat	1732..1763	CDD:293786
		ANK repeat	1765..1796	CDD:293786
		ANK repeat	1798..1826	CDD:293786
Dl	NP_001247193.1	MNNL	23..96	CDD:284966
		DSL	164..226	CDD:279722	20/72 (28%)
		EGF_CA	291..329	CDD:238011	14/37 (38%)
		EGF_CA	337..372	CDD:238011	14/35 (40%)
		EGF_CA	453..488	CDD:238011	12/34 (35%)
		EGF_CA	492..526	CDD:238011	15/33 (45%)
		EGF_CA	529..564	CDD:238011	18/34 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910