DRSC/TRiP Functional Genomics Resources

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Protein Alignment DRD2 and Oamb

DIOPT Version :10

Sequence 1:NP_000786.1 Gene:DRD2 / 1813 HGNCID:3023 Length:443 Species:Homo sapiens
Sequence 2:NP_001262774.1 Gene:Oamb / 43982 FlyBaseID:FBgn0024944 Length:751 Species:Drosophila melanogaster


Alignment Length:621 Identity:162/621 - (26%)
Similarity:247/621 - (39%) Gaps:217/621 - (34%)


- Green bases have known domain annotations that are detailed below.


Human     4 LNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLI-----AVIVFGNVLVCMAVSREK 63
            :|.:..:|.::...|:.|                |.|::|.:     .:::.||.||..||....
  Fly     1 MNETECEDLIKSVKWTEP----------------ANLISLAVLEFINVLVIGGNCLVIAAVFCSN 49

Human    64 ALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAI 128
            .|::.||:.||:||||||||...|:|:....||...|.|..:.|.|::.:||.||||||||||||
  Fly    50 KLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAI 114

Human   129 SIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFG-------------------- 173
            |:|||.||..|:.|.:..|:|:..: :|:.:|||||.|..|.|.|                    
  Fly   115 SLDRYVAVTRPVTYPSIMSTKKAKS-LIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLY 178

Human   174 ----------------------------------------------------------------- 173
                                                                             
  Fly   179 YTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTST 243

Human   174 ------------------------LNNADQN-----------ECIIANP-AFVVYSSIVSFYVPF 202
                                    ||...||           :|.:.|. .:|:||::.|||:|.
  Fly   244 STTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPM 308

Human   203 IVTLLVYIKIYIVLRRRRKRVN-----TKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGS 262
            .|.|..|.:||....|..:.:|     ||.|            ||..:..|:.:|...|.:..||
  Fly   309 FVMLFFYWRIYRAAVRTTRAINQGFKTTKGS------------KGIGSRFEEQRLTLRIHRGRGS 361

Human   263 FPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHH---QLTLPDPSH--------HG-- 314
               |::....:..:.:.....|.:.||...::|:.....||   ::::..||.        ||  
  Fly   362 ---NQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPSSENISELAGHGDV 423

Human   315 -------------LH-------STPDSPAKPEKNGH----------AKDHPKIAKIFEIQTMP-- 347
                         :|       .:.:|....::..|          .|..|::|: .:..|..  
  Fly   424 GHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGLPELAR-RQSNTSEAG 487

Human   348 -NGKTRTSLKTMSRRKLSQQ-----KEKKATQMLAIVLGVFIICWLPFFITHILNIHC-DCNIPP 405
             :|.:|.:.|.|.||.:..|     .|.||.:.|||::|:||.||.|||..:|:...| || :.|
  Fly   488 GSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDC-VDP 551

Human   406 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
            :|:|...||||.||||||:||..|:.:||.||.:|:
  Fly   552 LLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRII 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DRD2NP_000786.1 7tmA_D2_dopamine_R 35..437 CDD:320435 155/584 (27%)
TM helix 1 36..62 CDD:320435 9/30 (30%)
TM helix 2 69..92 CDD:320435 14/22 (64%)
TM helix 3 107..137 CDD:320435 21/29 (72%)
TM helix 4 152..170 CDD:320435 7/17 (41%)
TM helix 5 186..211 CDD:320435 11/25 (44%)
Interaction with PPP1R9B. /evidence=ECO:0000250 211..373 42/217 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..332 13/93 (14%)
TM helix 6 366..396 CDD:320435 16/34 (47%)
TM helix 7 405..430 CDD:320435 15/24 (63%)
OambNP_001262774.1 7tmA_Octopamine_R 21..583 CDD:320191 154/579 (27%)
TM helix 1 22..48 CDD:320191 7/25 (28%)
TM helix 2 55..81 CDD:320191 14/25 (56%)
TM helix 3 93..123 CDD:320191 21/29 (72%)
TM helix 4 135..158 CDD:320191 10/23 (43%)
TM helix 5 292..321 CDD:320191 12/28 (43%)
TM helix 6 512..542 CDD:320191 15/29 (52%)
TM helix 7 551..576 CDD:320191 15/24 (63%)

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