Protein Alignment DRD2 and AdoR

DIOPT Version :10

• Sequence 1: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Sequence 2: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 432
• Identity: 113/432 - (26%)
• Similarity: 187/432 - (43%)
• Gaps: 118/432 - (27%)

Human    19 SRPFNGSDGKADRPHYNYYATLLTLLIAVI-VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82
            |:....||..:...:..|  |:..:|:|:: :.|||||.:...||:.|:..|||.|||||:||||
  Fly    27 SKDAKDSDSPSSELNIPY--TVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLL 89

Human    83 VATLVMPWVVYLEVVGEWKFSRIHCDIF-VTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRY 146
            |..|.:|:.: |..:|..:  .:|..:| |:|.|::||.||..|.|:|:|||.|:..||.| :|.
  Fly    90 VGALGIPFAI-LASMGLPR--NLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAY-SRN 150

Human   147 SSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN---ECI---IANPAFVVYSSIVSFYVPFIVT 205
            ...|....:||:.||....:....|||. :||.|   ||:   :.:..::|:....:...|.::.
  Fly   151 VRTRTAIFIISMCWVAGTIVGFLPLFGW-HADVNHNQECLFVEVMDYNYLVFLYFATIITPALLM 214

Human   206 LLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRV 270
            |..|..||.|:.::.:::.|                                 .|.:..::||
  Fly   215 LAFYTHIYRVIIKQVRQIVT---------------------------------MNPASDLSRR-- 244

Human   271 EAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHP 335
                          ||.:..:.|                              .|.:.||
  Fly   245 --------------SSAAVVQVT------------------------------TPGRGGH----- 260

Human   336 KIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHC- 399
                           |.|.|:.:.   .:::::.||||.|:|::..|:|||:|.:..:.:...|
  Fly   261 ---------------TGTMLRVLG---AARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCP 307

Human   400 DCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
            ||.:.|.|......|.::||||||::|.....:||.|...:|
  Fly   308 DCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	108/410 (26%)
		TM helix 1	36..62	CDD:320435	9/26 (35%)
		TM helix 2	69..92	CDD:320435	15/22 (68%)
		TM helix 3	107..137	CDD:320435	15/30 (50%)
		TM helix 4	152..170	CDD:320435	4/17 (24%)
		TM helix 5	186..211	CDD:320435	4/24 (17%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		18/161 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		6/50 (12%)
		TM helix 6	366..396	CDD:320435	11/29 (38%)
		TM helix 7	405..430	CDD:320435	10/24 (42%)
AdoR	NP_651772.1	7tmA_Adenosine_R	42..345	CDD:341316	108/411 (26%)
		TM helix 1	43..69	CDD:341316	9/27 (33%)
		TM helix 2	76..103	CDD:341316	16/27 (59%)
		TM helix 3	112..142	CDD:341316	15/29 (52%)
		TM helix 4	156..174	CDD:341316	4/17 (24%)
		TM helix 5	196..225	CDD:341316	6/28 (21%)
		TM helix 6	273..303	CDD:341316	11/29 (38%)
		TM helix 7	313..338	CDD:341316	10/24 (42%)