DRSC/TRiP Functional Genomics Resources

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Protein Alignment DRD2 and Octbeta1R

DIOPT Version :10

Sequence 1:NP_000786.1 Gene:DRD2 / 1813 HGNCID:3023 Length:443 Species:Homo sapiens
Sequence 2:NP_651057.1 Gene:Octbeta1R / 42652 FlyBaseID:FBgn0038980 Length:508 Species:Drosophila melanogaster


Alignment Length:445 Identity:128/445 - (28%)
Similarity:198/445 - (44%) Gaps:132/445 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    19 SRPFNGSDGKADRPHYNYYATL-------LTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSL 76
            ::....|:|..|....:.:..|       :..:|...:.||:||.::|.|.:.|:..|||.:|||
  Fly    85 AQDIQASEGSTDDADGSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSL 149

Human    77 AVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141
            ||||:|||...|.:...:.:.|:|.|..:.||::.:.||...||||::||.||:|||.|:..|:.
  Fly   150 AVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLD 214

Human   142 YNTRYSSKRRVTVMISIVW----VLSFTISCPLLFGLNNADQN-ECIIANP---------AFVVY 192
            | ....::|||.:|:.:||    :|||   .|:..|.....:| :.:.:||         |:.:.
  Fly   215 Y-PLIMTQRRVFIMLLMVWLSPALLSF---LPICSGWYTTTENYKYLKSNPHICEFKVNKAYAIV 275

Human   193 SSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIM 257
            ||.:||::|.||.|.:|.:||....|:.:.|        :|:.:.|.|                 
  Fly   276 SSSMSFWIPGIVMLSMYYRIYQEADRQERLV--------YRSKVAALL----------------- 315

Human   258 KSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSP 322
                                 ||..:..|                 |:..|.||           
  Fly   316 ---------------------LEKHLQIS-----------------QIPKPRPS----------- 331

Human   323 AKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWL 387
                                ||.     .::::.||.|       |:||.:.|.|::..|:||||
  Fly   332 --------------------IQV-----EQSTISTMRR-------ERKAARTLGIIMSAFLICWL 364

Human   388 PFFITHILNIHCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
            |||:.:|::..|| |..|.:|.....|:||.|||:|||||..||.:||.||.|.|
  Fly   365 PFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTL 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DRD2NP_000786.1 7tmA_D2_dopamine_R 35..437 CDD:320435 121/423 (29%)
TM helix 1 36..62 CDD:320435 7/32 (22%)
TM helix 2 69..92 CDD:320435 14/22 (64%)
TM helix 3 107..137 CDD:320435 16/29 (55%)
TM helix 4 152..170 CDD:320435 7/21 (33%)
TM helix 5 186..211 CDD:320435 12/33 (36%)
Interaction with PPP1R9B. /evidence=ECO:0000250 211..373 22/161 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..332 5/50 (10%)
TM helix 6 366..396 CDD:320435 14/29 (48%)
TM helix 7 405..430 CDD:320435 12/24 (50%)
Octbeta1RNP_651057.1 7tmA_DmOct-betaAR-like 109..415 CDD:320194 120/415 (29%)
TM helix 1 109..135 CDD:320194 6/25 (24%)
TM helix 2 142..168 CDD:320194 14/25 (56%)
TM helix 3 180..210 CDD:320194 16/29 (55%)
TM helix 4 222..245 CDD:320194 10/25 (40%)
TM helix 5 269..298 CDD:320194 12/28 (43%)
TM helix 6 343..373 CDD:320194 15/36 (42%)
TM helix 7 383..408 CDD:320194 12/24 (50%)

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