Protein Alignment DRD2 and Oct-TyrR

DIOPT Version :10

• Sequence 1: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Sequence 2: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Alignment Length: 514
• Identity: 158/514 - (30%)
• Similarity: 240/514 - (46%)
• Gaps: 138/514 - (26%)

Human    38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF 102
            |.:|:::|.:.:.||:||.::|...|.|:...|:.|||||||||.||.||:|:.|...::|.|:|
  Fly   113 ALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEF 177

Human   103 SRIH-CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKR---RVTVMISIVWVLS 163
            . || |.:::|.||:.||:||||||||::|||.|:..|:    .|:.||   ||.::||.||:||
  Fly   178 G-IHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPI----NYAQKRTVGRVLLLISGVWLLS 237

Human   164 FTISCPLLFGLNN-----ADQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKR 222
            ..||.|.|.|.|:     .....| :.:...:|:|||:.||::|..:..:|||:|::..|||
  Fly   238 LLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRR--- 299

Human   223 VNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSN------GSFPV---------------- 265
                         ||...:.|       ||.|:.:||.      .|.||
  Fly   300 -------------LRERARAN-------KLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWL 344

Human   266 --NRRRVEAARRAQELEMEMLSSTS--PPERTRYSP----IPPSHHQLTLPDPSHH--------- 313
              .|.|.:.|....:.:.|.:||.:  |.:.::..|    .|...|.:.|...|..
  Fly   345 CCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKH 409

Human   314 -----GLHSTPDSPAKPE-----------------KNGHAKDHPKIAKI-FEIQTMPNG------ 349
                 |..|...|..:|.                 ..||:......|:| .|..:.|.|
  Fly   410 GKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCV 474

Human   350 ---KTRTSLKTM----------------------------SRRKLSQQKEKKATQMLAIVLGVFI 383
               ..:||||..                            .::|:|..||::|.:.|.|::|||:
  Fly   475 TQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFV 539

Human   384 ICWLPFFITHILNIHCDCNIPPVLYSAF-TWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
            |||||||:.:::...|....|...:..| |||||:||.:||:|||.||:::|:||.::|
  Fly   540 ICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	155/508 (31%)
		TM helix 1	36..62	CDD:320435	8/23 (35%)
		TM helix 2	69..92	CDD:320435	15/22 (68%)
		TM helix 3	107..137	CDD:320435	18/29 (62%)
		TM helix 4	152..170	CDD:320435	9/17 (53%)
		TM helix 5	186..211	CDD:320435	9/24 (38%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		47/260 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		15/87 (17%)
		TM helix 6	366..396	CDD:320435	15/29 (52%)
		TM helix 7	405..430	CDD:320435	13/25 (52%)
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	79/185 (43%)
		TM helix 1	111..137	CDD:320188	8/23 (35%)
		TM helix 2	144..170	CDD:320188	16/25 (64%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	12/22 (55%)
		TM helix 5	266..294	CDD:320188	11/27 (41%)
		7tm_GPCRs	<519..594	CDD:475119	34/74 (46%)
		TM helix 6	528..550	CDD:410628	12/21 (57%)
		TM helix 7	562..587	CDD:410628	13/24 (54%)