DRSC/TRiP Functional Genomics Resources

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Protein Alignment DRD2 and Octalpha2R

DIOPT Version :10

Sequence 1:NP_000786.1 Gene:DRD2 / 1813 HGNCID:3023 Length:443 Species:Homo sapiens
Sequence 2:NP_001262715.1 Gene:Octalpha2R / 42258 FlyBaseID:FBgn0038653 Length:740 Species:Drosophila melanogaster


Alignment Length:640 Identity:159/640 - (24%)
Similarity:257/640 - (40%) Gaps:207/640 - (32%)


- Green bases have known domain annotations that are detailed below.


Human     4 LNLSWYDDDLER----QNWSRPFNGSDGKADRPHY-----------NYYAT-------LLTLLIA 46
            ||.|:|:..|:.    .|.|.....:.|....|::           .|..|       ::|:|:.
  Fly    63 LNGSFYNSSLQLAAGFYNQSSASGATSGNLTNPNHTEVHWDGRYPSGYTLTHIVIASIIVTILMI 127

Human    47 VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFV 111
            :||.||:||.:|::.||:|:...|:.|.||||||..:..::||:.:..|::|.|.|....|||..
  Fly   128 IIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHS 192

Human   112 TLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFG--- 173
            .:||::|||||:|||.||:|||.::...:.| .:..:..|..|||:.||::|..|..|.|.|   
  Fly   193 AMDVLLCTASIMNLCLISLDRYWSITKAVDY-LKSRTPARAAVMITAVWIMSALICIPPLLGWKV 256

Human   174 ------LNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKR---VNTKRSS 229
                  |...:.:|.|    .:|:||::.|||:|..:.:.|||:||...:.|.:|   .:.::::
  Fly   257 KMPEGPLPKCELSEDI----GYVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTN 317

Human   230 RAFRAHLRAPLKGNCTHP-----------EDMKLCTVIMKSN-GSFPVNRRRVE-------AARR 275
            ...........||....|           :..::.|:....| .|.|:....|.       :...
  Fly   318 NEQVTSFTTAKKGTIPMPSSSGVSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSE 382

Human   276 AQELE--------------------MEMLSS------------TSPPERTRYSPIPPSHHQLTLP 308
            |.|||                    :.::||            :||.|..:.|.|......|.:|
  Fly   383 AGELEAVAAQTVLAYANPNGAGTNSVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVP 447

Human   309 DPSHHGLHS------------------------------TP------------------------ 319
            .|...|.:|                              ||                        
  Fly   448 VPPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALS 512

Human   320 ---DSPAKPEKNGHAKDHPKIAKIFEIQTM-------------PNGKTRTSLKTMS--------- 359
               |:....|.:..:.|...:::...::.:             .|.:.|...|..:         
  Fly   513 VGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVA 577

Human   360 ------------------------------------RRKLSQQKEKKATQMLAIVLGVFIICWLP 388
                                                :|:::::|||:||.:|.:::|.||.||||
  Fly   578 SKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLP 642

Human   389 FFITHILNIHCD--CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
            ||..:||...|.  ||||...::...||||:|||:||.|||.||.:||:||.:||
  Fly   643 FFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRIL 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DRD2NP_000786.1 7tmA_D2_dopamine_R 35..437 CDD:320435 146/588 (25%)
TM helix 1 36..62 CDD:320435 11/32 (34%)
TM helix 2 69..92 CDD:320435 10/22 (45%)
TM helix 3 107..137 CDD:320435 18/29 (62%)
TM helix 4 152..170 CDD:320435 7/17 (41%)
TM helix 5 186..211 CDD:320435 9/24 (38%)
Interaction with PPP1R9B. /evidence=ECO:0000250 211..373 41/330 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..332 16/119 (13%)
TM helix 6 366..396 CDD:320435 16/29 (55%)
TM helix 7 405..430 CDD:320435 12/24 (50%)
Octalpha2RNP_001262715.1 7tmA_alpha2_AR 132..>307 CDD:320187 68/179 (38%)
TM helix 2 150..176 CDD:320187 10/25 (40%)
TM helix 3 188..218 CDD:320187 18/29 (62%)
TM helix 4 230..253 CDD:320187 10/22 (45%)
TM helix 5 271..300 CDD:320187 13/32 (41%)
7tm_GPCRs <616..693 CDD:475119 38/76 (50%)
TM helix 6 626..648 CDD:410628 11/21 (52%)
TM helix 7 661..686 CDD:410628 12/24 (50%)

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