DRSC/TRiP Functional Genomics Resources

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Protein Alignment DRD2 and TyrR

DIOPT Version :10

Sequence 1:NP_000786.1 Gene:DRD2 / 1813 HGNCID:3023 Length:443 Species:Homo sapiens
Sequence 2:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster


Alignment Length:518 Identity:159/518 - (30%)
Similarity:239/518 - (46%) Gaps:103/518 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    22 FNGSDGKADRPHYNYYATLLT----LLIAVI-------VFGNVLVCMAVSREKALQTTTNYLIVS 75
            :|.|...|:..|  :|..:|:    :||||.       |.||.||.:|:...:.|:|.||..::|
  Fly    95 YNESAAAAEWAH--FYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMS 157

Human    76 LAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPM 140
            ||||||||...|||..|.:.::|.|:...:.|||:::|||::||||||:|||||:|||.||..|:
  Fly   158 LAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPL 222

Human   141 LYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGL---NNADQNEC-IIANPAFVVYSSIVSFYVP 201
            .|:.:..|||...:||.|||:|:..|:||.:.|.   ...|..|| ...|..:|::|::.||::|
  Fly   223 TYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIP 287

Human   202 FIVTLLVYIKIYIVLRRRRKR-----VNTKRSSRAFRAHLRAPLKGNCTHP-------------- 247
            ..|.:.||.:|..|:..|...     |:.|:..|...|.:...|.....|.              
  Fly   288 MAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTF 352

Human   248 ---------EDMKL-----------------------------CTVIM-------------KSNG 261
                     :||.|                             |..::             ..||
  Fly   353 SNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNG 417

Human   262 SFPVNR-RRVEAARRAQELEMEMLSSTSPPER---TRYSPIPPSH------HQLTLPDPSHHGLH 316
            .:.:.| ..::.|..|......|.|...|...   .::...||..      |.|:.|..:|...|
  Fly   418 CYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRH 482

Human   317 STPDSPAKPEKNGHAKDHPKI---AKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIV 378
            |..:...:..::.|  .||..   |.:....|..|....|:.|::|.|..|.:||.|.||.|:||
  Fly   483 SHGERDRERLRSHH--HHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIV 545

Human   379 LGVFIICWLPFFITHILN-IHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKI 440
            :|.||.|||||||.:::. ...:.....:|..|.||||:.|||:||.||..::::||.||.::
  Fly   546 VGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DRD2NP_000786.1 7tmA_D2_dopamine_R 35..437 CDD:320435 153/500 (31%)
TM helix 1 36..62 CDD:320435 12/36 (33%)
TM helix 2 69..92 CDD:320435 14/22 (64%)
TM helix 3 107..137 CDD:320435 21/29 (72%)
TM helix 4 152..170 CDD:320435 8/17 (47%)
TM helix 5 186..211 CDD:320435 9/24 (38%)
Interaction with PPP1R9B. /evidence=ECO:0000250 211..373 43/244 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..332 12/59 (20%)
TM helix 6 366..396 CDD:320435 18/29 (62%)
TM helix 7 405..430 CDD:320435 13/24 (54%)
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 80/185 (43%)
TM helix 1 118..144 CDD:320189 10/25 (40%)
TM helix 2 151..177 CDD:320189 15/25 (60%)
TM helix 3 189..219 CDD:320189 21/29 (72%)
TM helix 4 232..255 CDD:320189 10/22 (45%)
TM helix 5 272..297 CDD:320189 9/24 (38%)
7tm_GPCRs <533..605 CDD:475119 33/71 (46%)
TM helix 6 539..561 CDD:320189 15/21 (71%)
TM helix 7 573..598 CDD:320189 13/24 (54%)

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