Protein Alignment DRD2 and Dop1R1

DIOPT Version :10

• Sequence 1: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Sequence 2: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 127/459 - (27%)
• Similarity: 190/459 - (41%)
• Gaps: 142/459 - (30%)

Human    23 NGSDGKADRPHYN---------------------------YYATLLTLLIAVIVFGNVLVCMAVS 60
            ||.||......||                           .....|::||.:.|.||:|||:|:.
  Fly    90 NGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIY 154

Human    61 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNL 125
            .|::|:...|..:.|||:|||.||:|||.:....:::|.|.|....||.:|..|||..|||||||
  Fly   155 TERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNL 219

Human   126 CAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTIS-CPLLFGLNNADQ---------- 179
            ||||:|||..:..|:.|. |:.::|...:.|:.:|:|:..:| .|:..|::..||
  Fly   220 CAISMDRYIHIKDPLRYG-RWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKK 283

Human   180 -NECII-ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKG 242
             ..|.: ..|.:.|.||.:|||.|.:|.:.:|.::|...::..|.:..
  Fly   284 YPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKA----------------- 331

Human   243 NCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTL 307
             .|.|.::              ..::|.::.||             |..:.:...:...|
  Fly   332 -VTRPGEV--------------AEKQRYKSIRR-------------PKNQPKKFKVRNLH----- 363

Human   308 PDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKAT 372
                   .||:|         .|..||                                   ||.
  Fly   364 -------THSSP---------YHVSDH-----------------------------------KAA 377

Human   373 QMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 437
            ..:.:::|||:|||:|||..:|....|...|....:...|||||.|||.|||||:.||.|||.||
  Fly   378 VTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAF 442

Human   438 LKIL 441
            .:||
  Fly   443 KRIL 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	118/441 (27%)
		TM helix 1	36..62	CDD:320435	10/25 (40%)
		TM helix 2	69..92	CDD:320435	12/22 (55%)
		TM helix 3	107..137	CDD:320435	20/29 (69%)
		TM helix 4	152..170	CDD:320435	4/18 (22%)
		TM helix 5	186..211	CDD:320435	10/24 (42%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		17/161 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		6/50 (12%)
		TM helix 6	366..396	CDD:320435	12/29 (41%)
		TM helix 7	405..430	CDD:320435	13/24 (54%)
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	117/413 (28%)
		TM helix 1	130..156	CDD:320193	10/25 (40%)
		TM helix 2	163..189	CDD:320193	12/25 (48%)
		TM helix 3	201..231	CDD:320193	20/29 (69%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	11/28 (39%)
		TM helix 6	371..401	CDD:320193	14/64 (22%)
		TM helix 7	410..435	CDD:320193	13/24 (54%)