DRSC/TRiP Functional Genomics Resources

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Protein Alignment DRD2 and 5-HT2A

DIOPT Version :10

Sequence 1:NP_000786.1 Gene:DRD2 / 1813 HGNCID:3023 Length:443 Species:Homo sapiens
Sequence 2:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster


Alignment Length:596 Identity:155/596 - (26%)
Similarity:234/596 - (39%) Gaps:197/596 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    32 PH-YNYYATLLTLLIAVIVF----GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWV 91
            || |::    |.|.:...:|    ||:|||:||:.::.||..|||.:.|||:|||||:..|||..
  Fly   282 PHGYDF----LFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMG 342

Human    92 VYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVT-VM 155
            .....:|.|......|:|:||.||:.|::|||::|.||:.||..:..|:  .:|:.|.:|:| :.
  Fly   343 AIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPL--GSRHRSTKRLTGIK 405

Human   156 ISIVWVLSFTISCPL-LFGLNN-----ADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYI 214
            |:||||::..:|..: :.||.|     .:.|.|:|.|.||.|:.|:|:||:|.::.:..|.....
  Fly   406 IAIVWVMAMMVSSSITVLGLVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIP 470

Human   215 VLRRRRKRVNTKRSSRAFRAHLRAPLKGNCT-----HPEDMKLCTVIMKSNGSF----------- 263
            :||::.:.......|..||.     |.|..|     ..:.:::.:....||..|           
  Fly   471 LLRKKARFAAEHPESELFRR-----LGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFN 530

Human   264 ----------PVNRRRVEAARR-------AQELEMEML--------------------------- 284
                      |..|..||.|.|       |....|..:                           
  Fly   531 TEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSF 595

Human   285 ----------SSTSPPE-----------------------------RTRYSPIPPSHH------- 303
                      ||:||..                             ..|.|.:|||.|       
  Fly   596 RFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASV 660

Human   304 QLTLPDP---------------------------------------------------------- 310
            ::|:..|                                                          
  Fly   661 RVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQ 725

Human   311 ---SHHGLHSTPDSPAKPEKNGHAKDHP-KIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQ---KE 368
               .:|.:.....:..|||:....|..| |.|  |.....|....|.......|..||..   .|
  Fly   726 AAGGNHMVQKVKPTALKPEEPQRNKVRPFKFA--FNRVATPTLNLRFLNNRSKRNSLSANAVATE 788

Human   369 KKATQMLAIVLGVFIICWLPFFITHILNIHC-DCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIE 432
            :|||::|.:|...|::||.||||.:|:...| :|.:|..:.:...|||||:|.:||||||.||..
  Fly   789 QKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRT 853

Human   433 FRKAFLKILHC 443
            ||.||:::|.|
  Fly   854 FRAAFIRLLKC 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DRD2NP_000786.1 7tmA_D2_dopamine_R 35..437 CDD:320435 148/584 (25%)
TM helix 1 36..62 CDD:320435 10/29 (34%)
TM helix 2 69..92 CDD:320435 14/22 (64%)
TM helix 3 107..137 CDD:320435 15/29 (52%)
TM helix 4 152..170 CDD:320435 7/18 (39%)
TM helix 5 186..211 CDD:320435 10/24 (42%)
Interaction with PPP1R9B. /evidence=ECO:0000250 211..373 48/332 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..332 17/184 (9%)
TM helix 6 366..396 CDD:320435 14/32 (44%)
TM helix 7 405..430 CDD:320435 12/24 (50%)
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 67/176 (38%)
TM helix 2 321..343 CDD:410628 13/21 (62%)
TM helix 3 359..381 CDD:410628 11/21 (52%)
TM helix 4 404..420 CDD:410628 6/15 (40%)
TM helix 5 443..466 CDD:410628 8/22 (36%)
7tm_GPCRs <779..858 CDD:475119 35/78 (45%)
TM helix 6 792..814 CDD:410628 10/21 (48%)
TM helix 7 826..851 CDD:410628 12/24 (50%)

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