Protein Alignment DRD2 and Octbeta3R

DIOPT Version :10

• Sequence 1: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Sequence 2: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Alignment Length: 394
• Identity: 110/394 - (27%)
• Similarity: 173/394 - (43%)
• Gaps: 81/394 - (20%)

Human    23 NGS----DGKADRPHYNYYATLLTL-------LIAVIVFGNVLVCMAVSREKALQTTTNYLIVSL 76
            |||    |.:|:........:||.|       :|...|.||.||.::|.|.:.|:..|||.:|||
  Fly   117 NGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSL 181

Human    77 AVADLLVATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPM 140
            |:||:|||...|.:...:|:. |:|.|....|:::.:|||...|||||:||.||:|||.|:..|:
  Fly   182 AMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPL 246

Human   141 LYNTRYSSKRRVTVMISIVWVLSFTIS-CPLLFGLNNADQ---------NEC-IIANPAFVVYSS 194
            .|....:.| .|..|::.||:|...|| .|:..|....::         ::| .:.|.|:.:.||
  Fly   247 EYPLNMTHK-TVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALISS 310

Human   195 IVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRS----SRAFRAHLRAPLKGNCTHPEDMKL-CT 254
            .|||::|.||.|::|.:|:....|:||.::...|    :.....|.:.|...:..||.|..| .|
  Fly   311 SVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNAT 375

Human   255 VIMKSNGS----------------------------FPVNRRRVEAARRAQELEME----MLSST 287
            ...:...|                            .|..||...::...::||.|    :..:.
  Fly   376 SAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTD 440

Human   288 SPPERTRYSPIPPSHHQLTLPDPSHHGL----------------HSTPDSPAK----PEKNGHAK 332
            |.|.........|||:||..|.|..:..                ||.|:.|.:    ...:|:::
  Fly   441 SAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQLSLTSGSGNSE 505

Human   333 DHPK 336
            ..|:
  Fly   506 PEPE 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	105/378 (28%)
		TM helix 1	36..62	CDD:320435	10/32 (31%)
		TM helix 2	69..92	CDD:320435	13/22 (59%)
		TM helix 3	107..137	CDD:320435	17/29 (59%)
		TM helix 4	152..170	CDD:320435	7/18 (39%)
		TM helix 5	186..211	CDD:320435	12/24 (50%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		34/183 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		15/74 (20%)
		TM helix 6	366..396	CDD:320435
		TM helix 7	405..430	CDD:320435
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	71/196 (36%)
		TM helix 1	142..167	CDD:320194	7/24 (29%)
		TM helix 2	174..200	CDD:320194	13/25 (52%)
		TM helix 3	213..243	CDD:320194	17/29 (59%)
		TM helix 4	255..278	CDD:320194	9/23 (39%)
		TM helix 5	302..331	CDD:320194	13/28 (46%)
		7tm_GPCRs	<1161..1234	CDD:475119
		TM helix 6	1167..1189	CDD:410628
		TM helix 7	1202..1227	CDD:410628