DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Notch2 and frac

DIOPT Version :9

Sequence 1:	NP_035058.2	Gene:	Notch2 / 18129	MGIID:	97364	Length:	2473	Species:	Mus musculus
Sequence 2:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster

Alignment Length:	1641	Identity:	367/1641 - (22%)
Similarity:	522/1641 - (31%)	Gaps:	601/1641 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse   224 PCAPSPCVNGGTCRQTGDFTFECN---------CLPGFEGSTCERNIDDCPNHKCQNGGVCVDGV 279
            |..|.|.|:|...:.......|.|         ..|....:..|..:  ..|.......|..|.:
  Fly   163 PPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETETENEV--LENETPLKAEVQTDVL 225

Mouse   280 NTYNCRC-------PPQWTGQFCTEDVDEC------LLQPNACQNGGTCTNRNGGYGCVCVNGWS 331
            |:.|...       .|.:....|.||...|      ||.|:..|....|
  Fly   226 NSSNASVKVTNDPYEPTFLDNNCGEDNGGCAHICKRLLYPDENQPINKC---------------- 274

Mouse   332 GDDCSE--NIDDCAYASCTPGSTCIDRVASFSCLCPEGKAGLLCHLD-DACISNPCHKGALCDTN 393
              ||.|  .:|...||||                           || |.|:.:......:|:..
  Fly   275 --DCREGYTLDPNDYASC---------------------------LDIDECLESNGGCSEICENL 310

Mouse   394 PLNGQYICTCPQGY----KGADCTEDVDECAMAN-SNPCEHAGKCVNTDGAFHC----------- 442
            |  |:|.|:|.:||    .|..|. |::|||... |:.|:  |.|.|..|::.|
  Fly   311 P--GEYKCSCQEGYYLDESGKSCV-DINECANPELSSNCQ--GACENLPGSYRCVEPLEENPEIT 370

Mouse   443 ECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFK----GVHCELEVNECQ---- 499
            |.::.......|:.:|...|.|           .|.|  |..||:    |..|: ::|||:
  Fly   371 EVVENPIEKTNEVPVNVSESQP-----------AGKT--CNSGFQLSADGTDCQ-DINECEVDGP 421

Mouse   500 ---SNPCVNNGQCVDKVNRFQCLCPPGF----TGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQ 557
               .|..|...:|.:.:..|:|.|..|:    ....|.:|.......|.||..:|     .:|||
  Fly   422 EDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCALDSCTDLENPQLNRTRC-----AHECQ 481

Mouse   558 CATGFTGILCDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDEC--YSSPCLNDG 620
                                     ...:|  ||.|:|..||  .:..|| ..|  ..|||..:
  Fly   482 -------------------------DLPEG--SYRCVCPKGY--ELSEDQ-HSCLVQESPCSTE- 515

Mouse   621 RCIDLVNGYQCNCQPGTSGLNCEINFDDCASNPCMHGVCVDGINRYSCVCSPGFTGQ--RCNIDI 683
                  .|.: .|.|||    |..:.|:.:               :||:|..|:..:  .|. ||
  Fly   516 ------KGVE-KCSPGT----CLASEDNTS---------------FSCICPTGYRSEAFSCQ-DI 553

Mouse   684 DECASNPCRKGATCINDVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAG 748
            ||||.:......||.|...|::|.||||      .:.|.|                 |.||.:
  Fly   554 DECAEDTHLCSHTCQNTPGGYQCQCPEG------LNLVEE-----------------YTCLAE-- 593

Mouse   749 WVGVN-CEVDKNECLSNPC--QNGGTCNNLVNGYRCTCKKGFK----GYNCQVNIDECASNPCLN 806
                | |||:.|.| ...|  ..||.         |.|::||:    |.:|: ::|||    .:|
  Fly   594 ----NLCEVNNNGC-EQICLTARGGV---------CACREGFRLSADGKSCE-DVDEC----LVN 639

Mouse   807 QGTCFDDVSGYTCHCMLPYTGKNCQTVLAPCSPNPCENAAVCKEAPNFESFSCLCAPGWQ----- 866
            .|.|                                  ..||:..|.  |:.|:||.|::
  Fly   640 NGGC----------------------------------QQVCRNLPG--SYGCICAAGYELLKLD 668

Mouse   867 GKR--CTVDVDECISKP--CMNNGVCHNTQGSYVCECPPGFS-GMD-------CEEDINDCLANP 919
            |.|  | .|:|||..:.  |.:..:|.|..|||.|.||||:: |:|       ....|.|..::.
  Fly   669 GIRGYC-FDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSE 732

Mouse   920 CQNGGSCVDHVNTFSCQCHPGFIGDKCQTDMNECLSEPCKN--GGTCSDYVNSYTCTCPAGF--- 979
            ..:..:|:|.              |:|......| |..|:|  ||        :.|.||.|:
  Fly   733 TPSAHTCLDI--------------DECSLANGNC-SHFCQNEPGG--------FQCACPLGYALS 774

Mouse   980 HGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGF---TGPFCLHDINECSSNPCLNAGTCV 1041
            ..:....:||||.:|:......|::....|:|.|..||   ...|...||:|||.:....:..|:
  Fly   775 EDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSDICI 839

Mouse  1042 DGLGTYRCICPLGYTGKNCQTLVNLCSRSPCKNKGTCVQEKARPHCLCPPGWDGAYCDVLNVSCK 1106
            :.|||:.|.|..||              ...|:|.:|                      |:|...
  Fly   840 NLLGTHACACERGY--------------ELAKDKLSC----------------------LDVDEC 868

Mouse  1107 AAALQKGVPVEHLCQHSGICINAGNTHHCQCPLGY----TGSYCEEQLDECASNPCQHGATCNDF 1167
            |..|..|      |.|.  |||...|..|.|||||    .|..|...|..|.....:....|...
  Fly   869 AGLLSGG------CSHE--CINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPI 925

Mouse  1168 IGGYRCECVPGY---QGVNCEYEVDECQNQPCQNGG---TCIDLVNHFKCSCPPG----TRGLLC 1222
                  ||.|||   ....| .::||||.   ||||   .|.:....||||||||    :....|
  Fly   926 ------ECNPGYTLGSDDKC-VDIDECQK---QNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTC 980

Mouse  1223 EENIDECAGGPHCLNGGQCVDRIGGYTCR-----CLPGFAGERCEGDINECLSNPCSSEGSL--- 1279
            :: ||||.........|.|::.|||:.|.     .||         :|....|.|.|.:..|
  Fly   981 QD-IDECDQDKTSCITGTCINEIGGFRCEFPKFPVLP---------EIPTASSLPESPKIELKTP 1035

Mouse  1280 ---DCVQLKNNYNCICRSAFTGRHCETFLDVCPQKPC---------------------------- 1313
               |..:|.|.                 :...|:||.
  Fly  1036 KYPDFTELSNE-----------------IPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIP 1083

Mouse  1314 LNGGTCAVASNMPDGF---------ICRCPPGFSG--------------------ARCQSSCGQV 1349
            .:.....:...:|...         :|   |.|..                    :||:.||...
  Fly  1084 TSKAPVPLRPEVPKSLWVNQLQPRDLC---PRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSG 1145

Mouse  1350 KCRRGEQCIHTDS-----GP--RCFCLNPKDCESG--C-ASNPCQHGGTCYPQRQPPHYSCRCPP 1404
            ...:|.:....|:     ||  :|..:|....:|.  | |..|.|: |...|.      ||...|
  Fly  1146 YILQGPEIKSCDANGIWEGPETKCVAINQPRAQSPGICPALKPAQN-GVILPA------SCTQGP 1203

Mouse  1405 SFGGSHCELYTAPTSTPPATCQSQYCADKARDGICDEACNSHACQ----WDGGDCSLTMEDPWAN 1465
            |..|..|.|          .|.:         |.........||.    |..|
  Fly  1204 SRFGDVCRL----------QCNA---------GFVSTGSLLTACMMLQGWSFG------------ 1237

Mouse  1466 CTSTLRCWEY----INNQCDEQCNTAECL----FDNFECQRNSKTCKYDKYCADHFKD------- 1515
              :.|.|..:    :.||.....|:.:.:    ..|.|..|....|..:.....|..:
  Fly  1238 --ADLNCQPFGNGLLGNQLSPMWNSPKTVTPHQIQNVEQIRPYINCPENVVILLHAGEQKAHVTL 1300

Mouse  1516 ----NHCDQGCNSEECGWDG------------LDCASDQPE---NLAEGTLIIVVLLPPEQ---- 1557
                .:...|.......|.|            :|...:.||   .:...|:|.|....|.:
  Fly  1301 QRPQTNVKNGRLVAHPAWAGQLQGHLPAGVHKVDFRVNDPETKLTIKCHTIITVKAATPRESNPF 1365

Mouse  1558 ----LLQDSRSFL---RALGTLLHTNLRIKQDSQGALMVYPYFGEKSAAMKKQKMTR-RSLPEEQ 1614
                :...|||.|   ....||          |.|:...:|.|....|..|....|: :..|:.:
  Fly  1366 TLFRISDYSRSSLPRPAPFATL----------STGSSFSFPAFKALDATPKPVSFTKFQVFPDSE 1420

Mouse  1615 EQEQEVIGSKIFLEID 1630
            ..|...:||..|..::
  Fly  1421 SSEHSKLGSSSFFRLE 1436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Notch2	NP_035058.2	EGF_CA	109..143	CDD:238011
		EGF_CA	182..218	CDD:238011
		EGF_CA	260..296	CDD:238011	6/42 (14%)
		EGF_CA	298..335	CDD:238011	7/42 (17%)
		EGF_CA	415..454	CDD:238011	12/50 (24%)
		EGF_CA	456..492	CDD:238011	9/39 (23%)
		EGF_CA	495..530	CDD:238011	10/45 (22%)
		EGF_CA	532..567	CDD:238011	8/34 (24%)
		EGF_CA	570..604	CDD:238011	7/33 (21%)
		EGF_CA	608..643	CDD:238011	9/36 (25%)
		EGF_CA	645..679	CDD:238011	5/35 (14%)
		EGF_CA	682..717	CDD:238011	15/34 (44%)
		EGF_CA	757..793	CDD:238011	10/41 (24%)
		EGF_CA	795..831	CDD:238011	6/35 (17%)
		EGF_CA	873..909	CDD:238011	17/45 (38%)
		EGF_CA	911..947	CDD:238011	5/35 (14%)
		EGF_CA	949..985	CDD:238011	10/40 (25%)
		EGF_CA	987..1022	CDD:238011	11/37 (30%)
		EGF_CA	1025..1061	CDD:238011	13/35 (37%)
		EGF_CA	1117..1147	CDD:238011	13/33 (39%)
		EGF_CA	1151..1185	CDD:238011	7/36 (19%)
		EGF_CA	1188..1223	CDD:238011	17/41 (41%)
		EGF_CA	1225..1262	CDD:238011	12/41 (29%)
		EGF_CA	1264..1302	CDD:238011	8/43 (19%)
		EGF_CA	<1312..1343	CDD:238011	6/87 (7%)
		Notch	1423..1456	CDD:333809	6/36 (17%)
		Negative regulatory region (NRR). /evidence=ECO:0000250	1425..1679		44/256 (17%)
		NL	1459..1496	CDD:197463	6/44 (14%)
		Notch	1501..1534	CDD:333809	5/55 (9%)
		NOD	1540..1591	CDD:311024	13/64 (20%)
		NODP	1621..1675	CDD:311559	3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1755..1778
		ANKYR	<1820..1932	CDD:223738
		ANK repeat	1828..1875	CDD:293786
		ANK 1	1828..1872
		ANK 2	1877..1906
		ANK repeat	1878..1908	CDD:293786
		ANKYR	1880..2067	CDD:223738
		ANK 3	1910..1940
		ANK repeat	1944..1975	CDD:293786
		ANK 4	1944..1973
		Ank_2	1949..2041	CDD:338493
		ANK repeat	1977..2008	CDD:293786
		ANK 5	1977..2006
		ANK repeat	2010..2041	CDD:293786
		ANK 6	2010..2039
		GGN	<2070..>2390	CDD:317988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2122..2169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2382..2473
		DUF3454	2385..2441	CDD:314760
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	10/36 (28%)
		cEGF	396..415	CDD:289433	6/21 (29%)
		FXa_inhibition	425..458	CDD:291342	7/32 (22%)
		FXa_inhibition	476..505	CDD:291342	13/63 (21%)
		vWFA	<550..586	CDD:294047	16/42 (38%)
		FXa_inhibition	596..630	CDD:291342	13/43 (30%)
		FXa_inhibition	636..>664	CDD:291342	12/67 (18%)
		EGF_CA	676..715	CDD:284955	17/38 (45%)
		FXa_inhibition	745..780	CDD:291342	11/43 (26%)
		FXa_inhibition	786..821	CDD:291342	9/34 (26%)
		FXa_inhibition	827..862	CDD:291342	12/48 (25%)
		FXa_inhibition	874..904	CDD:291342	14/37 (38%)
		FXa_inhibition	945..980	CDD:291342	15/37 (41%)
		CCP	1110..1170	CDD:153056	11/62 (18%)
		CCP	1183..1235	CDD:153056	17/77 (22%)
		DUF5011	1468..1536	CDD:295940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910