DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Notch1 and frac

DIOPT Version :9

Sequence 1:NP_032740.3 Gene:Notch1 / 18128 MGIID:97363 Length:2531 Species:Mus musculus
Sequence 2:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster


Alignment Length: Identity:/ - (0%)
Similarity:/ - (0%) Gaps:/ - (0%)


- Green bases have known domain annotations that are detailed below.


Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Notch1NP_032740.3 EGF_CA 142..175 CDD:238011
EGF_CA 178..216 CDD:238011
EGF_CA 257..293 CDD:238011
EGF_CA 295..332 CDD:238011
EGF_CA 335..370 CDD:238011
EGF_CA 412..450 CDD:238011
Interaction with DLL4. /evidence=ECO:0000250|UniProtKB:Q07008 420..421
Interaction with DLL4. /evidence=ECO:0000250|UniProtKB:Q07008 448..452
EGF_CA 452..488 CDD:238011
EGF_CA 490..526 CDD:238011
EGF_CA 528..564 CDD:238011
EGF_CA 566..601 CDD:238011
EGF_CA 603..639 CDD:238011
EGF_CA 641..675 CDD:238011
EGF_CA 678..713 CDD:238011
EGF_CA 717..750 CDD:238011
EGF_CA 755..789 CDD:238011
EGF_CA 791..827 CDD:238011
EGF_CA 869..905 CDD:238011
EGF_CA 907..943 CDD:238011
EGF_CA 945..981 CDD:238011
EGF_CA 988..1019 CDD:238011
EGF_CA 1021..1057 CDD:238011
EGF_CA 1146..1180 CDD:238011
EGF_CA 1184..1219 CDD:238011
EGF_CA 1221..1265 CDD:238011
EGF_CA 1267..1305 CDD:238011
NL 1442..1479 CDD:197463
LNR 1 1449..1489
Notch 1487..1522 CDD:278494
LNR 2 1490..1531
Notch 1525..1561 CDD:278494
LNR 3 1532..1571
NOD 1567..1618 CDD:284282
NODP 1662..1719 CDD:284987
Interaction with PSEN1. /evidence=ECO:0000250|UniProtKB:P46531 1718..1750
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1770..1798
Ank_2 <1863..1948 CDD:289560
ANK repeat 1870..1915 CDD:293786
ANK 1912..2024 CDD:238125
ANK repeat 1917..1948 CDD:293786
ANK 1 1917..1946
Ank_2 1922..2015 CDD:289560
HIF1AN-binding 1937..1945
ANK repeat 1950..1981 CDD:293786
ANK 2 1950..1980
ANK 1979..2103 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK 3 1984..2013
Ank_2 1989..2081 CDD:289560
HIF1AN-binding 2004..2012
ANK repeat 2017..2081 CDD:293786
ANK 4 2017..2046
ANK 5 2050..2079
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2140..2185
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2382..2428
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2440..2531
DUF3454 2454..2516 CDD:288764
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342
cEGF 396..415 CDD:289433
FXa_inhibition 425..458 CDD:291342
FXa_inhibition 476..505 CDD:291342
vWFA <550..586 CDD:294047
FXa_inhibition 596..630 CDD:291342
FXa_inhibition 636..>664 CDD:291342
EGF_CA 676..715 CDD:284955
FXa_inhibition 745..780 CDD:291342
FXa_inhibition 786..821 CDD:291342
FXa_inhibition 827..862 CDD:291342
FXa_inhibition 874..904 CDD:291342
FXa_inhibition 945..980 CDD:291342
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
DUF5011 1468..1536 CDD:295940
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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