DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egl-36 and Shawl

DIOPT Version :9

Sequence 1:	NP_509795.1	Gene:	egl-36 / 181269	WormBaseID:	WBGene00001202	Length:	558	Species:	Caenorhabditis elegans
Sequence 2:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	278/558 - (49%)
Similarity:	352/558 - (63%)	Gaps:	105/558 - (18%)

- Green bases have known domain annotations that are detailed below.

Worm    36 DERIVLNVGGVRHETYQATLKKIPATRLSRLTPSLANFDPLLNEYFFDRHPAVFAMILNYYRTGK 100
            :.||:|||.|:|:|||:|||||||||||||||.:|||:||:||||||||||.||..|||||||||
  Fly     4 ENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTGK 68

Worm   101 LHYPTDVCGPLFEEELQYWGLDASDTEPCCWMQLLHAKDTQETLAVLDRMDADHEDDPQLREQDT 165
            ||||||||||||||||::||||::..|||||......:|||.|||:||::|.::|   :..|:..
  Fly    69 LHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENE---KPTEEQI 130

Worm   166 MKKFGWEEDYFQGKRTRWMKLKPQMWSLFDEPYSSQAAKLIAGISVLFIFISIFSFCLKTHQSFR 230
            .:.||:||....|:...|.::||::|::||||.||..||::||:||.|||:|:.|||||||..||
  Fly   131 ARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFR 195

Worm   231 LPVLIG------------------------------QNITMPGGVVQPSIE------------RV 253
            :.:..|                              .:||.|.|.:.|:..            ..
  Fly   196 VDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTA 260

Worm   254 STEPLPI------------------------------------------FGQ-------IEMLCN 269
            |.:..||                                          :||       :|::||
  Fly   261 SGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCN 325

Worm   270 IWFTLELIIRFVFCPSKIRFFKSPLNMIDLVATLSFYADAMMVRVVEDEPKDVVEFLSMIRIFRL 334
            :||.:|:|||.:..|:..:|.|||:|:||..||||||.|.|. |:  .|...::|..|::||.||
  Fly   326 VWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQ-RM--GEYTGLLEAFSIVRIMRL 387

Worm   335 FKLTQHHQGLQILIHTFRASAKELILLVFFLILGIVIFAALVYYAEKMEANPNNQFQSIPLGLWW 399
            ||||:|..||:||||||:||||||.||||||:||||.||:|.|||||::.||:|||:||||||||
  Fly   388 FKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWW 452

Worm   400 AICTMTTVGYGDMTPHTSFGRLVGSLCAVMGVLTIALPVPVIVSNFAMFYSHNQARDKLPKRRRR 464
            ||.|||||||||:.|.|..|..||:|||:.||||||||||||||||:|||||.|||.||||:|||
  Fly   453 AIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRR 517

Worm   465 VLPVEQIRL--------QARRHAAVLEPSASQGGLGGG 494
            ||||||.|.        :.|.:|....|....|.:.||
  Fly   518 VLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGG 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egl-36	NP_509795.1	BTB	39..132	CDD:197585	74/92 (80%)
		BTB_2	39..129	CDD:280393	71/89 (80%)
		Ion_trans	254..451	CDD:278921	126/245 (51%)
		Ion_trans_2	369..451	CDD:285168	61/81 (75%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	73/91 (80%)
		BTB_2	7..97	CDD:280393	71/89 (80%)
		Ion_trans	307..506	CDD:278921	125/201 (62%)
		Ion_trans_2	<449..499	CDD:285168	38/49 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880