Protein Alignment Nos2 and CG13667

DIOPT Version :10

• Sequence 1: NP_035057.1
• Gene: Nos2 / 18126
• MGIID: 97361
• Length: 1144
• Species: Mus musculus
• Sequence 2: NP_648220.1
• Gene: CG13667 / 38956
• FlyBaseID: FBgn0035890
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 652
• Identity: 175/652 - (26%)
• Similarity: 289/652 - (44%)
• Gaps: 135/652 - (20%)

Mouse   531 VRATVLFATETGKSEALARDL-ATLFSYAFNTKVVCMDQYKASTLEEEQLLLVVTSTFGNGDCPS 594
            :|..||:.::||.::.:|..: .......|...|:..|:|..:.|.||:|::.|.:|.|:|..|.
  Fly     1 MRLLVLYGSQTGTAQDVAEQIWRESHQLGFQGPVLPFDEYDMTKLIEERLVVFVVATTGDGVEPD 65

Mouse   595 NGQ-----TLKKSLFMLRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGD 654
            |.:     .||:||  ..:.....::|..|||.|.||:|...|..:.::|.:|||:.:.|.|..|
  Fly    66 NMKLAWRFLLKRSL--PAQSLQGMQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVCPVGLCD 128

Mouse   655 E----------LSGQEDAFRSWAVQTFRAACETFDVRSKHHI-------QIPKRF----TSNATW 698
            :          ||..:|.   |......:..:...:.:.|..       ::||..    ..|..|
  Fly   129 DQHDYGHLGVSLSWTKDL---WTALKGISGLDESKLSNSHQTTVKWSVKELPKDSQIAPMDNLLW 190

Mouse   699 EPQQYRLIQSPEPLDLNRALSSIHAKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGSRGPSYLP 763
            ..:|  ...|.:.||..|..:..|.::|..:||:.|..             .|::|        |
  Fly   191 SQKQ--TAHSFKILDNQRTTAVDHFQDVRFLRLQCQTE-------------DLSWE--------P 232

Mouse   764 GEHLGIFPGNQTALVQGILE------------RVVDCPTPHQTVCLEVLDESGSYWVKDKRLPPC 816
            |:.|.:.|.|....||...:            .:|:..:.||.:.|.:...:           |.
  Fly   233 GDVLDVQPQNSDEAVQTFFDLIREHSLNFDESTIVEVSSAHQDMPLPIAYSN-----------PL 286

Mouse   817 SLSQALTYFLDITTPPTQLQLHKLARFATDETDRQRLEALCQPSEYNDW-KFSNNP--TFLEVLE 878
            ||.||..:..|::..|.|..|..||:...||.::::|.........:|. .:.|.|  ..|||||
  Fly   287 SLLQAAKFVWDLSAKPRQRFLEVLAQNCCDEMEKEKLLEFSSAEGIDDLVAYVNRPRRNLLEVLE 351

Mouse   879 EFPSLHVPAAFLLSQL----PILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHH---- 935
            :|  .|..::..|.||    |:::||.:||:|  |.:...:.|.||||.|:|      :.|
  Fly   352 DF--RHATSSLTLQQLFEMMPLIQPRSFSIAS--DVSALSLDLLVAVVEYKT------IMHTPRL 406

Mouse   936 GVCSTWIRNLKPQDPVPCFVRSVSGFQL-----------PEDPSQPCILIGPGTGIAPFRSFWQQ 989
            |:||.|::.||            ||.:|           |:|.|.|.|::|||||||||||..|.
  Fly   407 GLCSNWLKTLK------------SGTELSGVVKRGTMVWPKDLSIPLIMVGPGTGIAPFRSIIQN 459

Mouse   990 RLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQEEMQEMV-RKRVLFQVHTGYSRLPGKPKVYVQDI 1053
            ||: :|.||...|.:.:.||||:...|..:..:..... .|:|  :.||.:|| ....|||||.:
  Fly   460 RLY-AQSKGATIGPLVVFFGCRNKAADFHFGNDFSTWTDAKQV--EAHTAFSR-DQDQKVYVQHL 520

Mouse  1054 LQKQLANEVLSVLHGEQGHLYICGDVRMARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYH 1118
            :.|..|: :..::.....::|:.|:   :.::..::|:.....|:...:.||   ..:| |:||.
  Fly   521 IAKNGAH-LARLIKDLNAYIYVAGN---SNNMPKSVKEAFIEILDGDADYVE---LMIK-QRRYQ 577

Mouse  1119 ED 1120
            |:
  Fly   578 EE 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nos2	NP_035057.1	DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000269|PubMed:20603330	23..27
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..59
		NOS_oxygenase_euk	78..490	CDD:238410
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P35228	509..529
		Flavodoxin_1	535..666	CDD:425562	42/146 (29%)
		FNR_like	730..1126	CDD:447143	119/426 (28%)
CG13667	NP_648220.1	Flavodoxin_1	5..136	CDD:425562	39/132 (30%)
		FNR_like	200..581	CDD:447143	124/446 (28%)