Protein Alignment Nos2 and Cpr

DIOPT Version :10

• Sequence 1: NP_035057.1
• Gene: Nos2 / 18126
• MGIID: 97361
• Length: 1144
• Species: Mus musculus
• Sequence 2: NP_477158.1
• Gene: Cpr / 33883
• FlyBaseID: FBgn0015623
• Length: 679
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 205/641 - (31%)
• Similarity: 328/641 - (51%)
• Gaps: 77/641 - (12%)

Mouse   523 MRKVMASRVRATVLFATETGKSEALARDLATLFSYAFNTKVVCMDQYKASTLE-------EEQLL 580
            ::|:.||.....|.:.::||..|..|..||. ....:..|.:..|..:....|       :..|.
  Fly    74 IKKLKASGRSLVVFYGSQTGTGEEFAGRLAK-EGIRYRLKGMVADPEECDMEELLQLKDIDNSLA 137

Mouse   581 LVVTSTFGNGDCPSNGQTLKKSLFM----LRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSH 641
            :...:|:|.||...|.....:.:..    |..||    |||||||:..|..:...|..:|::|..
  Fly   138 VFCLATYGEGDPTDNAMEFYEWITSGDVDLSGLN----YAVFGLGNKTYEHYNKVAIYVDKRLEE 198

Mouse   642 LGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFDVR-SKHHIQIPKRFTSNATWEPQQYRL 705
            |||:::...|.||:.:..||.|.:|..:.:.|.|:.|.:. ....:.|            :||||
  Fly   199 LGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLI------------RQYRL 251

Mouse   706 IQSPEPLDLNR----ALSSIH----------AKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGS 756
            ::.|: :..:|    .::.:|          |||.|...:|..:.|. :...|:.:.::|:.|||
  Fly   252 LEQPD-VQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELH-KGGGRSCMHIELSIEGS 314

Mouse   757 RGPSYLPGEHLGIFPGNQTALVQGILERVVDCPTPHQTVCLEVLDESGSYWVKDKRLP-PC--SL 818
            : ..|..|:|:.:||.|..:||:.:.:.   |.....||...:..::.|    .|:.| ||  :.
  Fly   315 K-MRYDAGDHVAMFPVNDKSLVEKLGQL---CNADLDTVFSLINTDTDS----SKKHPFPCPTTY 371

Mouse   819 SQALTYFLDITTPPTQLQLHKLARFATDETDRQRLEALCQPS-----EYNDWKFSNNPTFLEVLE 878
            ..|||::|:||..|....|.:||.:.|||.:::.|.::...|     :|..|........:.:||
  Fly   372 RTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILE 436

Mouse   879 EFPSLHVPAAFLLSQLPILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWIR 943
            :..|...|...:...||.|:|||||||||....|::||:|..:|.|:|..|:  ::.||.:|:::
  Fly   437 DIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGR--INKGVATTYLK 499

Mouse   944 NLKPQD----PVPCFVRSVSGFQLPEDPSQPCILIGPGTGIAPFRSFWQQR--LHDSQHKGLKGG 1002
            |.:||.    .||.|:|. |.|:||..|..|.|::|||||:||||.|.|:|  |.|   :|...|
  Fly   500 NKQPQGSEEVKVPVFIRK-SQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRD---EGKTVG 560

Mouse  1003 RMSLVFGCRHPEEDHLYQEEMQEMVRKRVLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLH 1067
            ...|.||||...||::|:.|::|.|:|..| .:...:||..|| |||||.:|: |.|:.:.:|:.
  Fly   561 ESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGK-KVYVQHLLE-QDADLIWNVIG 622

Mouse  1068 GEQGHLYICGDVR-MARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIF 1122
            ..:||.|||||.: ||.||...|.|:::||.|:||.....|..::::||||..|::
  Fly   623 ENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVW 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nos2	NP_035057.1	DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000269|PubMed:20603330	23..27
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..59
		NOS_oxygenase_euk	78..490	CDD:238410
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P35228	509..529		1/5 (20%)
		Flavodoxin_1	535..666	CDD:425562	39/141 (28%)
		FNR_like	730..1126	CDD:447143	147/408 (36%)
Cpr	NP_477158.1	Flavodoxin_1	86..223	CDD:425562	39/141 (28%)
		CYPOR	281..678	CDD:99801	151/414 (36%)