DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment syd-2 and zip

DIOPT Version :9

Sequence 1:	NP_509768.1	Gene:	syd-2 / 181255	WormBaseID:	WBGene00006364	Length:	1139	Species:	Caenorhabditis elegans
Sequence 2:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster

Alignment Length:	1253	Identity:	250/1253 - (19%)
Similarity:	483/1253 - (38%)	Gaps:	304/1253 - (24%)

- Green bases have known domain annotations that are detailed below.

Worm    40 MMNMLEDRDKL---QEQLENYKVQLENAGLRTKEVEKERDMMKRQFEVHTQNLPQELQTMTRELC 101
            ::.:.:..:||   :::|:..:.:|:.....|:|.|::    .:|..|....|.::||... |||
  Fly   927 LLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERK----YQQALVEKTTLAEQLQAEI-ELC 986

Worm   102 LLKEQLLEKDEEIVELKAERNNTRLLLEHLECLV-SRHERSLRMTVMKRQAQ-NHAGVSSEVEVL 164
                  .|.:|....|.|.:.....:::.||..: ...||.|.:...|::.: |...:..::|..
  Fly   987 ------AEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEE 1045

Worm   165 KALKSLFEHHKA-LDEKVRERLRVAMERVATLEEELSTKGDENSS-LKARIATYAAEAEEAMASN 227
            :|.:...:..|. ||.|:::           .||:|:...|:|.. ||.:
  Fly  1046 EAARQKLQLEKVQLDAKIKK-----------YEEDLALTDDQNQKLLKEK--------------- 1084

Worm   228 APINGSISSESANRLIEMQEALERMKTELANSLKQSTEITTRNAELEDQLTEDAREKHAAQESIV 292
                 .:..|.||.|.:.....|.....|| .||...|.|.  :|||::|.:|.:::..:..|..
  Fly  1085 -----KLLEERANDLSQTLAEEEEKAKHLA-KLKAKHEATI--SELEERLHKDQQQRQESDRSKR 1141

Worm   293 RLKNQICELDAQRTDQETRITTFESRFLTAQRESTCIRDLNDKLEHQLANKDAAVRLN---EEKV 354
            :::.::.:|..|..::..::...:::.  |:||....:.|. :::.:.|.|..|.:..   |.::
  Fly  1142 KIETEVADLKEQLNERRVQVDEMQAQL--AKREEELTQTLL-RIDEESATKATAQKAQRELESQL 1203

Worm   355 HSLQERLELAEKQLAQSLKKAESLPSVEAELQQRMEAL----------TAAEQKSVSAEERIQRL 409
            ..:||.|| |||   .:..|||   .|..:|.:.:|||          |||:|:..|..|
  Fly  1204 AEIQEDLE-AEK---AARAKAE---KVRRDLSEELEALKNELLDSLDTTAAQQELRSKRE----- 1256

Worm   410 DRNIQELSAELERAVQRERMNEE---------HSQRLSSTVDKLLSESNDRLQLHLKERMQALDD 465
                ||| |.|:::::.|.:|.|         |||.|:|..|:|  |:..:.:..|::....|:.
  Fly  1257 ----QEL-ATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQL--ENLRKAKTVLEKAKGTLEA 1314

Worm   466 KNR-LTQQLDGTKKIYDQAERIKDRLQRDNESLRQEIEALRQQLYNARTAQFQSRMHAIPFTHAQ 529
            :|. |..:|    :..:.:.:..||.::..||...|::....::..|| ::.|.:...:. ..|:
  Fly  1315 ENADLATEL----RSVNSSRQENDRRRKQAESQIAELQVKLAEIERAR-SELQEKCTKLQ-QEAE 1373

Worm   530 NIVQQ----QPQASIAQQSAYQMYKQQPAQQYQTVGMRRPNKGRISALQDDPNKVQTLNEQ--EW 588
            ||..|    :.:||.|.:||..|..|....|.......|...|..|.|:...::.:.|.||  |.
  Fly  1374 NITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEED 1438

Worm   589 DRLQQ------AHVLANVQQAFSSSPSLADV------GQSTLPRPNTAVQHQ------QDDMMNS 635
            |..::      |.|...:|:....:...||:      |:..|.:...|::.|      |:|.::
  Fly  1439 DEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLD- 1502

Worm   636 GMGMPSGMQGGMQGGMGGGQDAQMLASMLQD---RLDAINTEI-----------RLIQQEKHHAE 686
                               :..:.:.|.|:|   .|:|..|::           :::.:||..:|
  Fly  1503 -------------------KSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISE 1548

Worm   687 RVAEQLERSSREFYDDQ----GISTRSSPRASPQLDNMRQHKYNTLPANVSGDRRYDIYGNPQFV 747
            ::|::.:.:.||..:.:    .:| |....|..::::: ::|..||      ....|...|.|..
  Fly  1549 QIAQERDTAEREAREKETKVLSVS-RELDEAFDKIEDL-ENKRKTL------QNELDDLANTQGT 1605

Worm   748 DDRMVRDLDYEPRRGYNQFDEM------------------------------QYERDRMSPASSV 782
            .|:.|.:|:...|...:|..|:                              |:|||.::.....
  Fly  1606 ADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGA 1670

Worm   783 ASSTDGV---------------------LGGKKKRSNSSSGLKTLGRFFNK-KKNSSSDLFKRNG 825
            .....|:                     :..|||.......::|.....|| |:::.....|...
  Fly  1671 EEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQA 1735

Worm   826 DYSDGEQSGTEGNQKADYDRRKKKKHELLEEAMKARTPFALWNGPTVVAWLELWVGMPAWYVAAC 890
            ...|..:...|.....:..:...|:.|...:|::|..             |:|...:.:...|..
  Fly  1736 QVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEV-------------LQLTEDLASSERARR 1787

Worm   891 RANVKSGAIMSALSDQEIQKEIGISNPLHRLKLRLA-----IQEMVSLTSPSAPRTARLTLAFGD 950
            .|..:...:...:::...:..:.|... .||:.|:|     ::|..|.:.....|:.:..|....
  Fly  1788 AAETERDELAEEIANNANKGSLMIDEK-RRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQ 1851

Worm   951 MNHEYIGNDWLPCLGLAQYRSAFMECLLDARMLEHLSKRDLRTHLRMVDTFHRTSLQYGIMCLKK 1015
            :..|           ||..:|...:......:||..:| :|:..|..::|..||.::..|..|
  Fly  1852 LTTE-----------LANEKSNSQKNENGRALLERQNK-ELKAKLAEIETAQRTKVKATIATL-- 1902

Worm  1016 VNYDKKVLADRRKACDNINTDLLVW--SNERVQRWVEEIGLGV-FSRNLVD----------SGIH 1067
                :..:|:..:..:|...:.|:.  :|.::.:.::|:.:.: ..|..||          |.|.
  Fly  1903 ----EAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIK 1963

Worm  1068 GALIALDETFDASAFAYALQ----------------IGSQDVPNRQL--LEKKF-----IGLVND 1109
            .....||||.:      .||                |.||:..||::  |:.|.     |||.:.
  Fly  1964 LLKRNLDETEE------ELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSS 2022

Worm  1110 HRQQSDPHPRSGSSRKND 1127
            ....:....|:|.....|
  Fly  2023 RLTGTPSSKRAGGGGGGD 2040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
syd-2	NP_509768.1	BAR	<323..474	CDD:299863	48/173 (28%)
		Ferritin_like	<667..>728	CDD:294190	13/75 (17%)
		SAM_liprin-alpha1,2,3,4_repeat1	864..934	CDD:188961	11/74 (15%)
		SAM	864..930	CDD:197735	9/70 (13%)
		SAM_liprin-alpha1,2,3,4_repeat2	951..1016	CDD:188964	14/64 (22%)
		SAM	959..1015	CDD:197735	13/55 (24%)
		SAM_liprin-alpha1,2,3,4_repeat3	1036..1107	CDD:188967	23/106 (22%)
		SAM	1039..1109	CDD:197735	23/105 (22%)
zip	NP_523860.2	Myosin_N	80..117	CDD:280832
		Myosin_head	133..854	CDD:278492
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876
		Myosin_tail_1	931..2011	CDD:279860	243/1218 (20%)
		Prefoldin	1431..1515	CDD:298833	18/103 (17%)
		FAM76	<1847..1926	CDD:292665	18/96 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000