Protein Alignment DRD1 and 5-HT7

DIOPT Version :10

• Sequence 1: NP_000785.1
• Gene: DRD1 / 1812
• HGNCID: 3020
• Length: 446
• Species: Homo sapiens
• Sequence 2: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 426
• Identity: 144/426 - (33%)
• Similarity: 200/426 - (46%)
• Gaps: 104/426 - (24%)

Human     5 NTS--AMDGTGLVVER----DFSVRILTACFLS----LLILSTLLGNTLVCAAVIRFRHLRSKVT 59
            ||:  .:..|.|::|.    :|.:..||:.|:|    ::||.|::||.|||.||...|.|| :..
  Fly   134 NTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLR-RPC 197

Human    60 NFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYW 123
            |:.::|||:|||.||:||||...:.|:...|.||. .|:|||:||::|.||||||||.||||||.
  Fly   198 NYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYL 262

Human   124 AISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDS 188
            ||:.|..|..|.||:...:.:.:.|..:..||..|:.:.           ||.....|....|..
  Fly   263 AITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLIL-----------GNEHEDEEGQPICTV 316

Human   189 SLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALE-RAAVHAKNCQTTTGNGKPVE 252
            ..:..|.|.:::.|||||:::|:..|.:|:|.|    |||...| ||..|.:  |...|.|.|
  Fly   317 CQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAA----RRIVLEEKRAQTHLQ--QALNGTGSP-- 373

Human   253 CSQPES----------------------------------------------------------- 258
             |.|::
  Fly   374 -SAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSP 437

Human   259 ---SFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFG 320
               ..:....:|.|...||.:||..|..||||||||..|.||    ||..  :.::...:|:|.|
  Fly   438 HHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF----ETMH--VPASLSSLFLWLG 496

Human   321 WANSSLNPIIYA-FNADFRKAFSTLLGCYRLCPATN 355
            :|||.||||||| .|.||||.|..:|  |..|.:.|
  Fly   497 YANSLLNPIIYATLNRDFRKPFQEIL--YFRCSSLN 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	133/386 (34%)
		TM helix 1	25..51	CDD:320443	14/29 (48%)
		TM helix 2	59..86	CDD:320443	13/26 (50%)
		TM helix 3	96..126	CDD:320443	22/29 (76%)
		TM helix 4	138..161	CDD:320443	4/22 (18%)
		TM helix 5	191..221	CDD:320443	11/29 (38%)
		TM helix 6	265..295	CDD:320443	15/29 (52%)
		TM helix 7	310..335	CDD:320443	13/25 (52%)
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	131/381 (34%)
		TM helix 1	164..190	CDD:320452	12/25 (48%)
		TM helix 2	197..223	CDD:320452	13/25 (52%)
		TM helix 3	235..265	CDD:320452	22/29 (76%)
		TM helix 4	277..299	CDD:320452	4/21 (19%)
		TM helix 5	319..348	CDD:320452	10/28 (36%)
		TM helix 6	447..477	CDD:320452	15/29 (52%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)