DRSC/TRiP Functional Genomics Resources

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Protein Alignment DRD1 and TyrRII

DIOPT Version :10

Sequence 1:NP_000785.1 Gene:DRD1 / 1812 HGNCID:3020 Length:446 Species:Homo sapiens
Sequence 2:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster


Alignment Length:565 Identity:138/565 - (24%)
Similarity:207/565 - (36%) Gaps:237/565 - (41%)


- Green bases have known domain annotations that are detailed below.


Human     5 NTSAMDGTGLVVERD------------------------------FSVRILTACFLSLLILSTLL 39
            |:::.|||.|:::..                              :...:..|.|| ::||.|::
  Fly    27 NSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFL-VIILVTVV 90

Human    40 GNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFD 103
            |||||..||:..|.||: |||.||::||::|.||...|||...|..|.|.|.|| ..|:||::.|
  Fly    91 GNTLVILAVLTTRRLRT-VTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLD 154

Human   104 IMCSTASILNLCVISVDRYWAISSPFRYERKMTPK-AAFILISVAWTLSVLISFIPVQLSWHKAK 167
            |:..:.|||:||.||:|||.|::.|..|.:|...| .|.::|.|.|..::.|: .|..|.|::. 
  Fly   155 ILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSIT-CPPYLGWYEV- 217

Human   168 PTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRI---A 229
                    ....||.:| |..:.::.|.:.|::.||:||:.:|:..|.:|..:...:.:||   |
  Fly   218 --------GRHQAEFVD-CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDA 273

Human   230 ALERAA-----------------------------------VH---------------------- 237
            ..||.|                                   :|                      
  Fly   274 YSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCS 338

Human   238 -AKNCQTTTGN--------------------------------------------GKPVECSQP- 256
             ...|.:.||.                                            |.|...|.| 
  Fly   339 KCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPS 403

Human   257 -------ESSF----------------------------------------KMSF---------- 264
                   |:||                                        :.||          
  Fly   404 GMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHH 468

Human   265 ----------------------KRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFC 307
                                  ||::|..|||:::||..:.||||||:...::||.    .:|..
  Fly   469 GSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFL----PRPAV 529

Human   308 IDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLLGCYRLC 351
            ::...|. |.|.||.|.::||.|||| |.|||.||..|. |..:|
  Fly   530 LEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRLT-CRPIC 572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DRD1NP_000785.1 7tmA_D1A_dopamine_R 23..341 CDD:320443 128/505 (25%)
TM helix 1 25..51 CDD:320443 13/25 (52%)
TM helix 2 59..86 CDD:320443 13/26 (50%)
TM helix 3 96..126 CDD:320443 16/29 (55%)
TM helix 4 138..161 CDD:320443 7/23 (30%)
TM helix 5 191..221 CDD:320443 9/29 (31%)
TM helix 6 265..295 CDD:320443 14/29 (48%)
TM helix 7 310..335 CDD:320443 12/25 (48%)
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 77/204 (38%)
TM helix 1 78..101 CDD:410628 13/23 (57%)
TM helix 2 110..132 CDD:410628 11/21 (52%)
TM helix 3 148..170 CDD:410628 10/21 (48%)
TM helix 4 194..210 CDD:410628 4/16 (25%)
TM helix 5 233..256 CDD:410628 7/22 (32%)
7tm_GPCRs <491..563 CDD:475119 33/76 (43%)
TM helix 6 497..519 CDD:320098 11/21 (52%)
TM helix 7 531..556 CDD:320098 12/25 (48%)

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