DRSC/TRiP Functional Genomics Resources

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Protein Alignment DRD1 and 5-HT2B

DIOPT Version :10

Sequence 1:NP_000785.1 Gene:DRD1 / 1812 HGNCID:3020 Length:446 Species:Homo sapiens
Sequence 2:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster


Alignment Length:271 Identity:82/271 - (30%)
Similarity:131/271 - (48%) Gaps:54/271 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    32 LLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-F 95
            :|:|.|..||.|||.|:...|.|:: |||:|::|||::||:|||||||...:..:.|::|.|| .
  Fly    82 VLVLGTAAGNILVCLAIAWERRLQN-VTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEH 145

Human    96 CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQ 160
            |..|:..|::..||||::||.||||||.::..|.|:.|..|.:...:.|...|.||:.:| :|:.
  Fly   146 CLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMS-LPLS 209

Human   161 LSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQI 225
            |.:.|...:...:|.. .:.:.:          |.:..|::.||||:.:|::||....|:..:|.
  Fly   210 LMYSKNHASVLVNGTC-QIPDPV----------YKLVGSIVCFYIPLGVMLLTYCLTVRLLARQR 263

Human   226 RRIA---------------------ALERAAVHAKNCQTTTGNGKPV------------------ 251
            :.:.                     ||||.....:..:...||...|                  
  Fly   264 QNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDN 328

Human   252 -ECSQPESSFK 261
             |...|:||.|
  Fly   329 HELWLPDSSIK 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DRD1NP_000785.1 7tmA_D1A_dopamine_R 23..341 CDD:320443 82/271 (30%)
TM helix 1 25..51 CDD:320443 9/18 (50%)
TM helix 2 59..86 CDD:320443 15/26 (58%)
TM helix 3 96..126 CDD:320443 15/29 (52%)
TM helix 4 138..161 CDD:320443 6/22 (27%)
TM helix 5 191..221 CDD:320443 10/29 (34%)
TM helix 6 265..295 CDD:320443
TM helix 7 310..335 CDD:320443
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 70/197 (36%)
TM helix 1 75..101 CDD:320433 9/18 (50%)
TM helix 2 108..134 CDD:320433 15/25 (60%)
TM helix 3 146..176 CDD:320433 15/29 (52%)
TM helix 4 188..211 CDD:320433 6/23 (26%)
TM helix 5 229..258 CDD:320433 9/38 (24%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
Blue background indicates that the domain is not in the aligned region.

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