DRSC/TRiP Functional Genomics Resources

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Protein Alignment DRD1 and mAChR-B

DIOPT Version :10

Sequence 1:NP_000785.1 Gene:DRD1 / 1812 HGNCID:3020 Length:446 Species:Homo sapiens
Sequence 2:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster


Alignment Length:432 Identity:91/432 - (21%)
Similarity:158/432 - (36%) Gaps:118/432 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    24 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 88
            ||.|..|::.|:.|:.||.||..|.|..|::| :.:|:|:.|||.:|:|:..:.||:..:..:.|
  Fly   134 ILIAICLAICIILTVGGNILVLLAFIVDRNIR-QPSNYFIASLAATDMLIGTVSMPFYTIYVLKG 197

Human    89 FWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSV 152
            :|..| ..|::|::.|......|...:.:|::|||.::....:|....|......::::.|.:..
  Fly   198 YWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPA 262

Human   153 LISFIPVQLSWHK---AKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFY-IPVAIMIVT 213
            |:.||.: ..|..   .:...|.......|.:.|.|           ::.:|.:| ..:.::.|.
  Fly   263 LLFFISI-FGWEHFTGKRDLLPGQCAVQFLKDPIFN-----------TALIIGYYWTTLIVLFVL 315

Human   214 YTRIYRIAQKQIRRIAALER-----AAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKT 273
            |..||:.|....:|..|.:|     .|:.|.......|:...:...            |.|:|||
  Fly   316 YAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVI------------EEKILKT 368

Human   274 LSVIMG----VFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFN 334
            ...:.|    :...|      ...|....|||:..|..:.:...:                    
  Fly   369 KVELAGDQTDLDSAC------TTVIKRLSGSGQANPLAVATEEVE-------------------- 407

Human   335 ADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSE 399
                          ::.|                      .:.|.|.:|             ..|
  Fly   408 --------------KMTP----------------------EQRRASAAK-------------IQE 423

Human   400 DLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQP-ITQ 440
            :.||.|||..|...|:.|   |...|.|.:.|:.:.|. |||
  Fly   424 EAKKREAAVDAEKSERSS---SPAFDSDEESSVNQAQQLITQ 462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DRD1NP_000785.1 7tmA_D1A_dopamine_R 23..341 CDD:320443 70/330 (21%)
TM helix 1 25..51 CDD:320443 11/25 (44%)
TM helix 2 59..86 CDD:320443 9/26 (35%)
TM helix 3 96..126 CDD:320443 8/29 (28%)
TM helix 4 138..161 CDD:320443 4/22 (18%)
TM helix 5 191..221 CDD:320443 6/30 (20%)
TM helix 6 265..295 CDD:320443 7/33 (21%)
TM helix 7 310..335 CDD:320443 0/24 (0%)
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 46/188 (24%)
TM helix 2 168..194 CDD:320429 9/25 (36%)
TM helix 3 206..236 CDD:320429 8/29 (28%)
TM helix 4 248..271 CDD:320429 4/23 (17%)
TM helix 5 293..322 CDD:320429 8/39 (21%)
7tm_GPCRs <932..1008 CDD:475119
TM helix 6 941..963 CDD:410628
TM helix 7 976..1001 CDD:410628
Blue background indicates that the domain is not in the aligned region.

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