Protein Alignment DRD1 and 5-HT1A

DIOPT Version :10

• Sequence 1: NP_000785.1
• Gene: DRD1 / 1812
• HGNCID: 3020
• Length: 446
• Species: Homo sapiens
• Sequence 2: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 135/636 - (21%)
• Similarity: 204/636 - (32%)
• Gaps: 316/636 - (49%)

Human     9 MDGTG-------LVVERDFSVRI---LTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFV 63
            ::|||       .|.|.||:..:   :|:..|.|:||.|::||..|.||:|..|:|:: |.|:.|
  Fly   202 INGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQN-VANYLV 265

Human    64 ISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISS 127
            .||||:||.||.||||..||.||:..|..| ..|:||.:.|::|.|||||:|..|:||||||:::
  Fly   266 ASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN 330

Human   128 PFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSR 192
             ..|....|....|::|...||.:|::|..| |..|        .|.:.....|. ..|..|...
  Fly   331 -IDYIHSRTSNRVFMMIFCVWTAAVIVSLAP-QFGW--------KDPDYLQRIEQ-QKCMVSQDV 384

Human   193 TYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRR------------------------------ 227
            :|.:.::..:||:|:.:::..|.:||:.|:|:|.|
  Fly   385 SYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRL 449

Human   228 ---------------------------------------------------IAALERAAVHAKN- 240
                                                               :.:..||.|.|.:
  Fly   450 RLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPST 514

Human   241 ----------------------------------------------------------------- 240
                                                                             
  Fly   515 SGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGP 579

Human   241 --------------------C-------------------------------------------- 241
                                |
  Fly   580 QPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTIT 644

Human   242 -------QTTTGNGKPV----------------ECSQ--------------PESSFK-------- 261
                   ||.|..|..:                .|:|              ||...:
  Fly   645 SISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQ 709

Human   262 -------------------------------MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCIL 295
                                           :..|||.|..|||::|.|.||.||||||::...:
  Fly   710 PHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTM 774

Human   296 PFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLL 345
            |.|.:.:     |..:...:|:|.|:.||:|||:||. |:.:||:||..:|
  Fly   775 PLCAACQ-----ISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	125/609 (21%)
		TM helix 1	25..51	CDD:320443	12/25 (48%)
		TM helix 2	59..86	CDD:320443	16/26 (62%)
		TM helix 3	96..126	CDD:320443	18/29 (62%)
		TM helix 4	138..161	CDD:320443	7/22 (32%)
		TM helix 5	191..221	CDD:320443	7/29 (24%)
		TM helix 6	265..295	CDD:320443	17/29 (59%)
		TM helix 7	310..335	CDD:320443	11/25 (44%)
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	75/197 (38%)
		TM helix 1	228..254	CDD:320454	12/25 (48%)
		TM helix 2	261..287	CDD:320454	16/25 (64%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	7/22 (32%)
		TM helix 5	383..412	CDD:320454	7/28 (25%)
		7tm_GPCRs	<743..816	CDD:475119	33/77 (43%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	10/24 (42%)