Protein Alignment DRD1 and Drd1

DIOPT Version :10

• Sequence 1: NP_000785.1
• Gene: DRD1 / 1812
• HGNCID: 3020
• Length: 446
• Species: Homo sapiens
• Sequence 2: NP_036678.3
• Gene: Drd1 / 24316
• RGDID: 2518
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 443
• Identity: 404/443 - (91%)
• Similarity: 418/443 - (94%)
• Gaps: 1/443 - (0%)

Human     5 NTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVS 69
            |||.||..||..|||||.|||||||||||||||||||||||||||||||||||||||||||||||
  Rat     4 NTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVS 68

Human    70 DLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERK 134
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
  Rat    69 DLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERK 133

Human   135 MTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET-IDNCDSSLSRTYAISS 198
            |||||||||||||||||||||||||||||||||||.|.|||.|||.:| .||||:.|||||||||
  Rat   134 MTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISS 198

Human   199 SVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMS 263
            |:|||||||||||||||.||||||||||||:|||||||||||||||.|||.||||:|.|||||||
  Rat   199 SLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMS 263

Human   264 FKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNP 328
            |||||||||||||||||||||||||||.||::|||||.|||||||||.|||||||||||||||||
  Rat   264 FKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNP 328

Human   329 IIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPH 393
            |||||||||:||||||||||||||.|||||||||||||||.:|||||||||||||:|||||||||
  Rat   329 IIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPH 393

Human   394 AVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT 446
            |||||||||||||.|||:||||||||||||||||||||||||||:|.:|||.|
  Rat   394 AVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	295/318 (93%)
		TM helix 1	25..51	CDD:320443	25/25 (100%)
		TM helix 2	59..86	CDD:320443	26/26 (100%)
		TM helix 3	96..126	CDD:320443	29/29 (100%)
		TM helix 4	138..161	CDD:320443	22/22 (100%)
		TM helix 5	191..221	CDD:320443	27/29 (93%)
		TM helix 6	265..295	CDD:320443	28/29 (97%)
		TM helix 7	310..335	CDD:320443	23/24 (96%)
Drd1	NP_036678.3	7tm_GPCRs	22..341	CDD:475119	295/318 (93%)
		TM helix 1	25..49	CDD:320443	23/23 (100%)
		TM helix 2	59..81	CDD:320443	21/21 (100%)
		TM helix 3	96..118	CDD:320443	21/21 (100%)
		TM helix 4	141..157	CDD:320443	15/15 (100%)
		TM helix 5	192..215	CDD:320443	21/22 (95%)
		TM helix 6	271..293	CDD:320443	20/21 (95%)
		TM helix 7	310..335	CDD:320443	23/24 (96%)