Protein Alignment DRD1 and dop-1

DIOPT Version :10

• Sequence 1: NP_000785.1
• Gene: DRD1 / 1812
• HGNCID: 3020
• Length: 446
• Species: Homo sapiens
• Sequence 2: NP_001370620.1
• Gene: dop-1 / 180714
• WormBaseID: WBGene00001052
• Length: 460
• Species: Caenorhabditis elegans
• Alignment Length: 450
• Identity: 146/450 - (32%)
• Similarity: 197/450 - (43%)
• Gaps: 132/450 - (29%)

Human    31 SLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF 95
            |:||:..|.||.|||||::..|.||.:..|.|::|||||||||:||||.:.||.:|.|:||||.|
 Worm    13 SVLIILALFGNLLVCAAILWDRSLRKQPENLFLVSLAVSDLLVSVLVMLFAAVNDILGYWPFGQF 77

Human    96 -CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPV 159
             |..|::|||...||||||||.||:||||.||.|..|.|....:....:|.:.|.:|..|...|:
 Worm    78 YCQFWISFDITTCTASILNLCAISLDRYWHISRPMVYIRYCNRRRINYVIVLVWLISAGIGAAPL 142

Human   160 QLSWHKAKPTSPSDGNATSLAETIDN------CDSSLSRTYAISSSVISFYIPVAIMIVTYTRIY 218
                          |.......||:|      |:..|...|||.||::||::|..:|::.||::|
 Worm   143 --------------GFGFGSKVTINNLTGLPVCEMRLPLPYAIGSSMVSFFLPAMVMVILYTKLY 193

Human   219 RIAQKQIRRI--------------------------------------AALERAAV-----HAKN 240
            ..|:|.:|.|                                      .|.||..:     :::.
 Worm   194 LYARKHVRSIKTQLQQATSFLIMQLASEKIREVTAATLKGEALLPPDSPATERTTMTVSRHYSRR 258

Human   241 CQTTTGNGKP------------VECSQPESSFKMSFKRET------------------------- 268
            ..|||....|            ||..:.....|::|...|
 Worm   259 STTTTTTATPRRGDKKTSSQNKVESIRTSIFSKLNFLCPTRFKNQRSPQDPHTPAAHNRSNISDQ 323

Human   269 KVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYA- 332
            |...||.||||.|:.||||||.:|.:..:.      |....|.|.....|.|:||||.||:||:
 Worm   324 KARLTLGVIMGTFLVCWLPFFTVNILRAWL------PEIFSSKTIMAVTWLGYANSSANPLIYSI 382

Human   333 FNADFRKAFSTLL----GCYRLCPATNNAI--------------------ETVSINNNGA 368
            ||.|||:||..::    ||....|..|.:|                    |:...|||.|
 Worm   383 FNRDFRRAFKKIIVRVFGCCWEEPDLNKSISSRYAAPDNIERRRSCTRSSESAHDNNNDA 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	134/397 (34%)
		TM helix 1	25..51	CDD:320443	11/19 (58%)
		TM helix 2	59..86	CDD:320443	17/26 (65%)
		TM helix 3	96..126	CDD:320443	19/29 (66%)
		TM helix 4	138..161	CDD:320443	5/22 (23%)
		TM helix 5	191..221	CDD:320443	12/29 (41%)
		TM helix 6	265..295	CDD:320443	16/54 (30%)
		TM helix 7	310..335	CDD:320443	13/25 (52%)
dop-1	NP_001370620.1	7tmA_Ap5-HTB1-like	7..391	CDD:320193	134/397 (34%)
		TM helix 1	7..33	CDD:320193	11/19 (58%)
		TM helix 2	41..67	CDD:320193	17/25 (68%)
		TM helix 3	79..109	CDD:320193	19/29 (66%)
		TM helix 4	121..143	CDD:320193	5/35 (14%)
		TM helix 5	166..195	CDD:320193	12/28 (43%)
		TM helix 6	320..350	CDD:320193	15/29 (52%)
		TM helix 7	359..384	CDD:320193	12/24 (50%)