DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zig-4 and DIP-delta

DIOPT Version :9

Sequence 1:	NP_509335.1	Gene:	zig-4 / 181051	WormBaseID:	WBGene00006981	Length:	253	Species:	Caenorhabditis elegans
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	246	Identity:	52/246 - (21%)
Similarity:	94/246 - (38%)	Gaps:	52/246 - (21%)

- Green bases have known domain annotations that are detailed below.

Worm    14 INAHPPMHAEMHSAVVTLANEIDTNYLTSPAKIKIVAPLESALIPGGETYQLRCDIMSTPAATIH 78
            :|.:|.:....:..||...|.:|..  ::|:         |..:...:...:.|.....||..|.
  Fly   127 VNTNPMISQVGYLQVVVPPNILDIE--STPS---------SVAVRENQNINMTCRADGFPAPKII 180

Worm    79 WKFNGKLIQGSNELNVEEKLLNFGKAIVDTGIVASILTIQCPSAENSGTYSCVGYNG---HQTIE 140
            |:     .:...|:.||:|    .|.:|   ..|.:|.:...|....|.|.|:..||   ..:..
  Fly   181 WR-----REDGEEIAVEKK----KKVLV---YDADVLPLTKVSRNEMGAYLCIATNGVPPSVSKR 233

Worm   141 TVAEVEIEGEASGCRSNHKSAPEIVFWTDSRF--EMTGNVATLVC--RANQQVDWVWMSNDELVK 201
            .:.:||.             :|.|  |..::.  ..:|...|:.|  .|:.:....|:.|..:|.
  Fly   234 IILDVEF-------------SPMI--WVPNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYNSVMVL 283

Worm   202 NNDKF-------TVLSNGDLVIKNIVWDDMGTYTCIARNQFGEARQETFLY 245
            .:.|:       :..::..|.|:|:.:.|.|.|.||::|..||......:|
  Fly   284 PSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVY 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zig-4	NP_509335.1	I-set	47..147	CDD:254352	21/102 (21%)
		Ig	65..144	CDD:143165	19/81 (23%)
		IG_like	176..245	CDD:214653	19/77 (25%)
		Ig	<193..238	CDD:299845	14/51 (27%)
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	3/15 (20%)
		Ig	145..238	CDD:416386	23/115 (20%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	2/13 (15%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/9 (22%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	1/3 (33%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	0/7 (0%)
		Ig	242..333	CDD:416386	22/92 (24%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	1/9 (11%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900