Protein Alignment Nkx2-5 and C15

DIOPT Version :10

• Sequence 1: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Sequence 2: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Alignment Length: 318
• Identity: 86/318 - (27%)
• Similarity: 122/318 - (38%)
• Gaps: 121/318 - (38%)

Mouse    15 KDILNLEQQQRSLASGDLSARLEATLAPASCMLAAFKPEAYSGPE--AAASGLAELRAEMGPAPS 77
            |::|..|..       ||:.:|..::|.::...||   ..||.|.  .:|:|...||.
  Fly   120 KELLQQEDH-------DLAYKLATSIANSTYGSAA---ALYSYPHLYPSAAGGHVLRV------- 167

Mouse    78 PPKCSPAFPAAPTFYPGAYGDPDPAKDPRADKKELCALQKAVELDKAETDGAERPRARR------ 136
            ||:.:|...|.|..:..|...       :|.|..|               .|..|.|||
  Fly   168 PPQRTPLTWALPPLHHAALAH-------QAVKDRL---------------AAAFPIARRIGHPYQ 210

Mouse   137 ------RRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQ 195
                  |:|||..|::.||.|||:||.:|:||::.||..||..||:|..|||.||||||.|.:||
  Fly   211 NRTPPKRKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQ 275

Mouse   196 RQDQTLELLGPPPPPARRIAVPVLVRDGKPCLGDPAAYAPAYGVGLNAYGYNAYPYPSYGGAACS 260
            ..::.         .|.|.|...|:                  :.|.|             .|.|
  Fly   276 TAEER---------EAERQAANRLM------------------LSLQA-------------EAIS 300

Mouse   261 PGYSCAAYPAAPPAAQPPAASANSNFVNFGVGDLNTVQSPGMPQGNSGVSTLHGIRAW 318
            .|:   |.|:||..:|               |.:|     |.|     ::.|||::.|
  Fly   301 KGF---APPSAPLGSQ---------------GGVN-----GAP-----LAALHGLQPW 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	28/49 (57%)
C15	NP_476873.2	COG5576	<196..315	CDD:227863	53/176 (30%)
		Homeodomain	218..274	CDD:459649	31/55 (56%)