Protein Alignment Nkx2-5 and lbe

DIOPT Version :10

• Sequence 1: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Sequence 2: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Alignment Length: 320
• Identity: 77/320 - (24%)
• Similarity: 116/320 - (36%)
• Gaps: 138/320 - (43%)

Mouse     3 PS-PALTPTP---------------FSVKDILNLEQQQRSLASGDLSARLEATLAPASCMLAAFK 51
            || |:..|.|               ||:.|||...::||.          |:...|.:..|.|
  Fly   109 PSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQRE----------ESVSPPPNANLLA-- 161

Mouse    52 PEAYSGPEAAASGLAELRAE---MGPA--------------PSPPKCSPAFPAAPTFYPGA---- 95
            |.| |.|.|.:.||.:.|.|   :.||              |......|..|..| |.|.|
  Fly   162 PPA-SRPIAPSGGLLQPRTEPLDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRP-FIPSALLHY 224

Mouse    96 ------------------------YGDPDPA----KDPRADKK----------ELCALQKAVELD 122
                                    :...:||    :|..:::.          |.|:.::|.:|:
  Fly   225 EQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLE 289

Mouse   123 KAET-DGAE------------------------------------------------RPRARRRR 138
            |..| :|:|                                                ||:.:::|
  Fly   290 KLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKR 354

Mouse   139 KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQD 198
            |.|..|:..|::|||:||..|:|||..:||::|:.|.|::.||..||||||.|.||..::
  Fly   355 KSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEE 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	25/49 (51%)
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	28/55 (51%)