Protein Alignment Nkx2-5 and tin

DIOPT Version :10

• Sequence 1: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Sequence 2: NP_524433.1
• Gene: tin / 42536
• FlyBaseID: FBgn0004110
• Length: 416
• Species: Drosophila melanogaster
• Alignment Length: 374
• Identity: 94/374 - (25%)
• Similarity: 120/374 - (32%)
• Gaps: 175/374 - (46%)

Mouse     3 PSP-------ALTPTPFSVKDILNLEQQQRSL--ASGDLSARLEATLAPASCMLAAFKPEAYSGP 58
            |||       ||..||||||||||:..|..:.  :.|.:..     .|.||.:.||.:   |..|
  Fly    22 PSPGSLTNADALNTTPFSVKDILNMVNQTEAYEGSYGHIDG-----AATASALFAAGE---YQNP 78

Mouse    59 EAAASGLAELRAEMGPAP--------------SPPKCSPAFPAAP-------------------- 89
            ....:.....::|: |.|              :....||..|..|
  Fly    79 HQYLNHQQHQQSEL-PIPQQQLHHQHLDDGATTSSSLSPLLPPPPHQLYGGYQDYGMPAHMFQHH 142

Mouse    90 --------------------TFYPGA--------------------------------------- 95
                                .||.||
  Fly   143 HGHPHQSFQHSASAYNMSASQFYAGASATAYQTPATYNYNYAGSGEVYGGATPSAVGIKSEYIPT 207

Mouse    96 -YGDPDPAKD---------PRADKKELC-----------------------------------AL 115
             |..|.|..|         .:|..::||                                   ..
  Fly   208 PYVTPSPTLDLNSSAEVDSLQAPTQKLCVNPLSQRLMETASNSSSLRSIYGSDEGAKKKDNSQVT 272

Mouse   116 QKAVELDKAETDGAERP-------RARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASV 173
            ....||.|....|...|       :.|.:||||||||||||.|||.||:.::||:..||:.:|..
  Fly   273 SSRSELRKNSISGNSNPGSNSGSTKPRMKRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQK 337

Mouse   174 LKLTSTQVKIWFQNRRYKCKRQRQD-----QTLELLGPP-------PPP 210
            |.|::|||||||||||||.||...|     :.|:|...|       |||
  Fly   338 LNLSATQVKIWFQNRRYKSKRGDIDCEGIAKHLKLKSEPLDSPTSLPPP 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	31/49 (63%)
tin	NP_524433.1	Homeodomain	302..358	CDD:459649	37/55 (67%)