Protein Alignment Nkx2-5 and ems

DIOPT Version :10

• Sequence 1: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Sequence 2: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Alignment Length: 359
• Identity: 76/359 - (21%)
• Similarity: 103/359 - (28%)
• Gaps: 180/359 - (50%)

Mouse     3 PSPALTP------------------TPFSVKDILNLEQQ---QRSLASGDLSARLEATLAPASCM 46
            |.|.|:|                  ||.|.:||..|.|:   ..::|||         |:|....
  Fly   108 PHPHLSPAQQHVLHQHLLMQQQHPGTPKSHQDIQELLQRLHHNAAMASG---------LSPLQTR 163

Mouse    47 LAAFKPEAYSGPEAAASGLAELRAEMGPAP-----------------SPPKC------------- 81
            |:   ||. ..|:.|.|    |:.|..|||                 :|||.
  Fly   164 LS---PET-EQPQMAVS----LKRERSPAPPAMEQAENPAQRIQPPHTPPKSVSPQSSQPSSSPT 220

Mouse    82 ------------------SPAFPAAPTFYPGAYGD------------------------------ 98
                              .|.:|.....:||..|.
  Fly   221 LLISSPHATPPQQQQQQPPPNYPKPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPPMPQGQPG 285

Mouse    99 -PD---------------PAKDPR----ADKKELCALQKAVELDKAETDGAER------------ 131
             ||               |..:|.    |..:...|||....|..|....|..
  Fly   286 LPDIKALPPYINAPPELPPQHNPHLIAAAQFQMAAALQAGHVLGPAAAAAAAAGLPPHAAQFMPN 350

Mouse   132 --------------------------------PRARRRRKPRVLFSQAQVYELERRFKQQRYLSA 164
                                            |..|:.::.|..||.:|:.:||..|:..:|:..
  Fly   351 PGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVVG 415

Mouse   165 PERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQD 198
            .||..||..|.|:.||||:||||||.|.||.:|:
  Fly   416 AERKALAQNLNLSETQVKVWFQNRRTKHKRMQQE 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	24/49 (49%)
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	25/55 (45%)