Protein Alignment Nkx2-5 and Scr

DIOPT Version :10

• Sequence 1: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Sequence 2: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 71/286 - (24%)
• Similarity: 107/286 - (37%)
• Gaps: 77/286 - (26%)

Mouse     4 SPALTPTPFSVKDILNLEQQQRSLASGDLSARLEATLAPASCMLAAFKPEAYSGPEAAASGLAEL 68
            ||.|:|:  ||     :|...|||..|.|...|.|.                    |||:||...
  Fly   216 SPKLSPS--SV-----VESVARSLNKGVLGGSLAAA--------------------AAAAGLNNN 253

Mouse    69 RAEMGPAPSPPKCSPAFPAAPTFYPGAYGDPDPAKDP-------------RADKKELCALQKAVE 120
            .:..|.:..|...:     .|...||. ||.|...|.             :.:..::....|.|.
  Fly   254 HSGSGVSGGPGNVN-----VPMHSPGG-GDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVH 312

Mouse   121 LDKAETDGAERPRAR-RRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIW 184
            |      |.....|. ..::.|..:::.|..|||:.|...|||:...|.::|..|.||..|:|||
  Fly   313 L------GTSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIW 371

Mouse   185 FQNRRYKCKRQRQDQTLEL----LGPPPPPARRIAVPVLVRDGKPCLGDPAAYA-----PAY--- 237
            |||||.|.|::.:..::.:    :||...|..:..:            .|:.:|     .|:
  Fly   372 FQNRRMKWKKEHKMASMNIVPYHMGPYGHPYHQFDI------------HPSQFAHLSAXDAWHFS 424

Mouse   238 GVGLNAYGYNAYPYPSYGGAACSPGY 263
            |.|.........||.:...|:.:.||
  Fly   425 GTGXRLNQLYQEPYQTAAAASAASGY 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	23/49 (47%)
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	24/55 (44%)