Protein Alignment Nkx2-5 and Dfd

DIOPT Version :10

• Sequence 1: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Sequence 2: NP_477201.1
• Gene: Dfd / 40832
• FlyBaseID: FBgn0000439
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 271
• Identity: 66/271 - (24%)
• Similarity: 108/271 - (39%)
• Gaps: 87/271 - (32%)

Mouse    97 GDPDPAKDPRAD----KKELCALQKAVELDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFK 157
            ||.|..:|..|:    ::.:....|.:.: ....:|:.:|....:|: |..:::.|:.|||:.|.
  Fly   324 GDSDSDEDLMAETTDGERIIYPWMKKIHV-AGVANGSYQPGMEPKRQ-RTAYTRHQILELEKEFH 386

Mouse   158 QQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQR--------QDQTLELLGPPPP----P 210
            ..|||:...|.::|..|.|:..|:||||||||.|.|:..        :.:|::..|.|.|    |
  Fly   387 YNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGNPTPVAKKP 451

Mouse   211 ARRIA--------------------VPVL---VR-DGKPCLGDPAAYAPAYGVGLNAYGYNAYPY 251
            .:|.|                    .||:   :| |....:||.::
  Fly   452 TKRAASKKQQQAQQQQQSQQQQTQQTPVMNECIRSDSLESIGDVSS------------------- 497

Mouse   252 PSYGGAACSPGYSCAAYPAAP------PAAQPPAASANSNFVNFGVGDLNTVQSPGMPQGNS--- 307
             |.|    :|.|    .||||      |.:|...::.|:|    |.|:.|...:......|:
  Fly   498 -SLG----NPPY----IPAAPETTSSYPGSQQHLSNNNNN----GSGNNNNNNNNNNSNLNNNNN 549

Mouse   308 ----GVSTLHG 314
                |.:.|||
  Fly   550 NNQMGHTNLHG 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	22/49 (45%)
Dfd	NP_477201.1	Homeodomain	367..423	CDD:459649	24/56 (43%)