Protein Alignment Nkx2-5 and lms

DIOPT Version :10

• Sequence 1: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Sequence 2: NP_611491.2
• Gene: lms / 37322
• FlyBaseID: FBgn0034520
• Length: 378
• Species: Drosophila melanogaster
• Alignment Length: 365
• Identity: 96/365 - (26%)
• Similarity: 132/365 - (36%)
• Gaps: 131/365 - (35%)

Mouse     9 PTPFSVKDILNLEQQQRSLASGDLSARLEATLAPASCMLAAFKPEAYSGPEAAASGLAELRAEMG 73
            |..||::.|| .:.:.||..|.:.|.:.|:... .:|:          |...|:|
  Fly    11 PHSFSIEQIL-AKPEMRSSTSFEDSVQDESGRG-GNCL----------GASRASS---------- 53

Mouse    74 PAPSPPKCSPAFPAAPTFYPGAYGDPDPAKDPRADKKELCALQKAVELDKAETDGAERPRARRRR 138
              |:...|.                .|...|.::|            :|.|..||......|::|
  Fly    54 --PATSSCL----------------DDNMDDGKSD------------IDLASDDGNGLGDDRKKR 88

Mouse   139 KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLEL 203
             ||..||.||:..||..|::.:|||..:|..||..|:||.||:||||||||.|.||:.......|
  Fly    89 -PRTAFSAAQIKALETEFERGKYLSVAKRTALAKQLQLTETQIKIWFQNRRTKWKRKYTSDVETL 152

Mouse   204 -------LGPPPPPARRIAVPVLVRDGKPCLGD--------PAAYAPAYGVGLNAYGYNA----- 248
                   ||     ...:|.|::|       ||        |....|...:.||..|..|
  Fly   153 ASHYYAQLG-----IGGLARPMVV-------GDRLWLFSQTPTGPTPIQSIMLNGSGSAAPMASA 205

Mouse   249 --------YPYPSYGGAACSPGYSCA----------------AYP---AAPPAAQPPAAS----- 281
                    .||.:.||....||.|..                |.|   |.|||...||||
  Fly   206 TTATGSPMRPYATSGGMPPLPGPSVMESARNAILARGQPLNFALPFGVAKPPAGGVPAASYIPRC 270

Mouse   282 --ANSNFVNFGVGDLNTVQS---------PGMPQGNSGVS 310
              ..:::|:: ...|.|.:|         |  |:..||.|
  Fly   271 KPYATSYVDY-AASLPTNESYLQMKYATLP--PEAESGAS 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	27/49 (55%)
lms	NP_611491.2	Cnd2	33..>106	CDD:450400	25/124 (20%)
		Homeodomain	87..143	CDD:459649	30/56 (54%)