Protein Alignment Nkx2-5 and en

DIOPT Version :10

• Sequence 1: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Sequence 2: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 307
• Identity: 72/307 - (23%)
• Similarity: 107/307 - (34%)
• Gaps: 121/307 - (39%)

Mouse     4 SPALTPTPFSVKDILNLEQQQRSLASGDLSARLEATLAPASCMLAAFKPEAY------------- 55
            |...||:.|:..|:|...:||::.|    :|...|.:...:..|..|.|.||
  Fly   210 SQTATPSAFTRVDLLEFSRQQQAAA----AAATAAMMLERANFLNCFNPAAYPRIHEEIVQSRLR 270

Mouse    56 ------------------SGPEAAASG-LAELRAEMG-PA----------------PSPPK---- 80
                              :.||.:|.| |.:..:::| ||                .|||.
  Fly   271 RSAANAVIPPPMSSKMSDANPEKSALGSLCKAVSQIGQPAAPTMTQPPLSSSASSLASPPPASNA 335

Mouse    81 -------------------CSPA---FPAAPTFYPGAYG--------DPDPAKDPRADKKELCAL 115
                               ||.|   ..::|:...||.|        .|.|...|.|..:: ..:
  Fly   336 STISSTSSVATSSSSSSSGCSSAASSLNSSPSSRLGASGSGVNASSPQPQPIPPPSAVSRD-SGM 399

Mouse   116 QKA----VELDKAETDGAER-------------------PRARR----------RRKPRVLFSQA 147
            :.:    .|.....|:|.:.                   ||.||          .::||..||..
  Fly   400 ESSDDTRSETGSTTTEGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSE 464

Mouse   148 QVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKR 194
            |:..|:|.|.:.|||:...|.||:|.|.|...|:||||||:|.|.|:
  Fly   465 QLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKK 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	24/49 (49%)
en	NP_523700.2	Homeodomain	455..511	CDD:459649	26/55 (47%)
		Engrail_1_C_sig	512..542	CDD:431338	72/307 (23%)