Protein Alignment Nkx2-5 and B-H1

DIOPT Version :10

• Sequence 1: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Sequence 2: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 370
• Identity: 94/370 - (25%)
• Similarity: 133/370 - (35%)
• Gaps: 118/370 - (31%)

Mouse    22 QQQRSLASGDLSARLEATLAPASCMLAAFKPEAYSGPEAAASGLAELRAEMGPAPSPPKCSPAFP 86
            ||..:.|:...:||..|..|.|:.  ||          |||:|:|          :|| ......
  Fly   194 QQHYAAAAAAAAARNNAAAAAAAA--AA----------AAAAGVA----------APP-VDGGVD 235

Mouse    87 AAPTFYPGAYGDPDPAKD----------PRADKKELCALQKAVELDKAETDGAERPR---ARRRR 138
            ......|.|.||.|.:.|          ...|...:|:.....:...:...|:....   ::::|
  Fly   236 GGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCSNGGKDDDGNSVKSGSTSDMSGLSKKQR 300

Mouse   139 KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLEL 203
            |.|..|:..|:..||:.|::|:|||..||.:||..|.|:..|||.|:||||.|.|||.. ..|||
  Fly   301 KARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQTA-VGLEL 364

Mouse   204 LGPPPPPARRIAVPVLVRDGKPCLG----------------------------------DPAAY- 233
            |.    .|...|....:..|.|.||                                  .|..|
  Fly   365 LA----EAGNFAAFQRLYGGSPYLGAWPYAAAAGAAHGATPHTNIDIYYRQAAAAAAMQKPLPYN 425

Mouse   234 ----APAYGVGLNAYGYNAYPYP--------------SY------GGAACSPGYSCAAYPAAPPA 274
                .|:.|||:   |....|.|              ||      ..:|.:||   ..:|.|||.
  Fly   426 LYAGVPSVGVGV---GVGVGPAPFSHLSASSSLSSLSSYYQSAAAAASAANPG---GPHPVAPPP 484

Mouse   275 A-----------QP-PAASANSNFVNFGVGDLNTVQSPGMPQGNS 307
            :           :| ||.||:::.........:...:||.|.|.|
  Fly   485 SVGGGSPPSGLVKPIPAHSASASPPPRPPSTPSPTLNPGSPPGRS 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	24/49 (49%)
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	27/55 (49%)